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Negative pressure wound therapy: violation of ethical and scientific standards

Eurekalert - 19 hours 28 min ago
The treatment has been used in hospitals for over 20 years, and more than 100 studies have been completed worldwide. But manufacturers and researchers are concealing a large proportion of the results.
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Eradicating Helicobacter pylori infections may be a key treatment for Parkinson's disease

Eurekalert - 19 hours 28 min ago
While human genetic mutations are involved in a small number of Parkinson's disease (PD) cases, the vast majority of cases are of unknown environmental causes, prompting enormous interest in identifying environmental risk factors involved.
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Take a step back from yourself to better realize the benefits of awe

Eurekalert - 19 hours 28 min ago
Religion and nature can both lead to awe, and turning to one or the other is a common coping strategy for the stress. But an awe-inspiring experience can have negative consequences as well as benefits, according to a novel UB-led study that uses cardiovascular responses to stress to take a broad look at awe and the critical role perspective plays when considering the effects of encountering awe.
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Study shows invasive lung cancer surgery can lead to long-term opioid use

Eurekalert - 19 hours 28 min ago
Patients treated with more-invasive surgical techniques for a type of early-stage lung cancer are more likely to become chronic opioid users than patients treated with minimally invasive surgery.
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Ancient Mars had right conditions for underground life, new research suggests

Eurekalert - 19 hours 28 min ago
A new study shows that the breakdown of water molecules trapped in ancient Martian rocks likely produced enough chemical energy to sustain microorganisms for hundreds of millions of years beneath the Red Planet's surface.
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Clinical trial investigators violate EU regulations: Entries in EU Register are incomplete

Eurekalert - 19 hours 28 min ago
Compliance of pharma companies is relatively good, but very poor for university research groups. Research funders should make allocation of further funding dependent on data transparency.
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Promising phase 1/2 results for entrectinib against ROS1+ non-small cell lung cancer

Eurekalert - 19 hours 28 min ago
Results of phase 1 and phase 2 clinical trials of the drug entrectinib in ROS1-positive non-small cell lung cancer (NSCLC) presented on the press program of the International Association for the Study of Lung Cancer (IASLC) 19th World Conference on Lung Cancer show a response rate of 77.4 percent for 53 patients evaluable for response, with median duration of response of 24.6 months.
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Lawnmower injuries a persistent source of serious injury and high costs, new study affirms

Eurekalert - 19 hours 28 min ago
In what Johns Hopkins Medicine researchers call an unusually comprehensive analysis of nationwide data, they conclude that the rate of lawnmower injuries persists at close to 6,400 a year, most of them requiring surgery and hospitalization, and costing an average of $37,000 per patient.
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Dosimetry and toxicity studies of a sulfonamide derivative of Sulforhodamine 101

Eurekalert - 19 hours 28 min ago
The SR101 N-(3-[18F]Fluoropropyl) sulfonamide ([18F]SRF101) is a Sulforhodamine 101 derivative that was previously synthesised by our group. The fluorescent dye SR101 has been reported as a marker of astroglia in the neocortex of rodents in vivo. The aim of this study was to perform a toxicological evaluation of [18F]SRF101 and to estimate human radiation dosimetry based on preclinical studies.
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The theranostic complex with two toxic modules shows great toxicity for tumour cells

Eurekalert - 19 hours 28 min ago
Emerging cancer nanotechnology enables target-delivery of substantial payloads of drugs to cancer sites with concomitant reduction of side-effects due to the lesser accumulation in the critical organs. This prompts loading of nanocarriers with therapeutic cargo and contrast agents, allowing combined cancer therapy and tumour visualization, respectively. Researchers from Lobachevsky University of Nizhny Novgorod, Russia, have implemented such combined therapy using conjugates of radionuclide yttrium-90-doped upconversion nanoparticles (UCNP) and targeted toxin.
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Call for new approaches to fill significant gaps in understanding Parkinson's disease

Eurekalert - 19 hours 28 min ago
New paper calls for the use of advances human-relevant methods to enable understanding of the initiation and progression of Parkinson's disease.
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Does our environment affect the genes in our brains?

Eurekalert - 19 hours 28 min ago
Is there a link between differences in IQ test performance and the activity of certain genes? Researchers from Charité -- Universitätsmedizin Berlin have shown that modifications in the structure of a specific gene have a negative impact on individual test performance. This suggests that environmentally-induced epigenetic changes to our genetic material have a greater impact on intelligence than previously thought. Results from this study have been published in Translational Psychiatry.
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Results from the ReCre8 trial reported at TCT 2018

Eurekalert - 19 hours 28 min ago
The first large, randomized trial comparing a novel polymer-free amphilimus-eluting stent to the latest-generation permanent polymer drug-eluting stent found that the polymer-free stent was clinically safe and effective.
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Novel drug-eluting stent with improved radiographic visibility found to be safe and effective

Eurekalert - 19 hours 28 min ago
This first randomized clinical study of a polymer-coated zotarolimus-eluting stent (Resolute Onyx) that utilizes a novel thin-strutted metallic platform allowing for better x-ray visibility was shown to be non-inferior to an ultrathin-strutted bioresorbable polymer-coated sirolimus-eluting stent (Orsiro) that uses a cobalt-chromium strut platform.
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A fracture anywhere reduces bone density everywhere

Eurekalert - 19 hours 28 min ago
New studies from UC Davis Health are among the first to associate fractures with systemic bone loss. They also begin the path to finding treatments that preserve long-term skeletal health and reduce susceptibility to additional fractures and, potentially, osteoporosis.
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Neurobehavioral symptoms predictive of employment outcome after traumatic brain injury

Eurekalert - 19 hours 28 min ago
'Our results indicate that frontal neurobehavioral symptoms may be predictive of the ability to achieve and maintain employment after TBI,' said Dr. Weber, lead author, and a research scientist at Kessler Foundation. 'Developing rehabilitative strategies that address these behaviors could improve employment outcomes,' she noted, 'and reduce the burden of care on caregivers and society.'
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Asian-Americans more likely to be hired to lead troubled companies

Eurekalert - 19 hours 28 min ago
Asian-Americans are more than twice as likely to be hired as CEOs when a company is struggling, possibly setting them up for failure, according to new research published by the American Psychological Association.
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Weight loss can be boosted fivefold thanks to novel mental imagery technique

Eurekalert - 19 hours 28 min ago
A new study has shown how overweight people lost an average of five times more weight using Functional Imagery Training (FIT) -- a brief individual motivational intervention that teaches self-motivating skills using mental imagery -- compared with talking therapy alone. The study was led by the University of Plymouth and Queensland University.
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Breakthrough in blending metals

Eurekalert - 19 hours 28 min ago
Researchers in Japan have found a way to create innovative materials by blending metals with precision control. Their approach, based on a concept called atom hybridization, opens up an unexplored area of chemistry that could lead to the development of advanced functional materials.
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Cancer cells evade immunotherapy by hiding telltale marker, suggesting how to stop relapse

Eurekalert - 19 hours 28 min ago
Harnessing the immune system to treat cancer shows great promise in some patients, but for many, the response does not last long-term. In an effort to find out why, Fred Hutchinson Cancer Research Center scientists are using a new technology to look at how cancer cells change under the pressure of immunotherapy treatments.
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