Body

Tight junctions are multi-protein complexes that serve as barriers in epithelial tissues such as the skin or lining of the gut. Loss of a specific tight junction barrier protein, claudin 18, occurs in the majority of gastric cancer patients and is correlated with poor prognosis in patients with advanced gastric cancer. Understanding how claudin 18 loss occurs and what pathways it regulates may provide new strategies to inhibit neoplastic progression in human gastric cancer patients.

Researchers at Stanford University, Palo Alto, California, have created a noninvasive technology that detects when nerve cells fire based on changes in shape. The method could be used to observe nerve activity in light-accessible parts of the body, such as the eye, which would allow physicians to quantitatively monitor visual function at the cellular level. The study was published in the journal Light: Science and Applications. The work was funded by the National Eye Institute, part of the National Institutes of Health.

OTTAWA - The Council of Canadian Academies (CCA) has released three reports on requests for medical assistance in dying (MAID), the result of an independent Expert Panel review conducted at the request of the federal government. The reports were released following their tabling in Parliament today.

Philadelphia, December 12, 2018 - For men newly diagnosed with prostate cancer or patients previously treated, the risk of metastasis is a crucial determinant of whether to choose conservative management or undergo further treatment. For prostate as well as other cancers, primary tumor growth or spread is driven by amplifications or deletions of portions of the genome known as copy number alterations (CNAs).

Philadelphia, December 12, 2018 - Pseudoachondroplasia (PSACH) is a severe inherited dwarfing condition characterized by disproportionate short stature, joint laxity, pain, and early onset osteoarthritis. In PSACH, a genetic mutation leads to abnormal retention of cartilage oligomeric matrix protein (COMP) within the endoplasmic reticulum (ER) of cartilage-producing cells (chondrocytes), which interferes with function and cell viability.

Sixty years after melatonin was isolated and with more than 23,000 published studies showing the many functions of this hormone secreted by the pineal gland, guidelines should be discussed and established for its therapeutic use.

(Philadelphia, PA) - During an ischemic attack, the heart is temporarily robbed of its blood supply. The aftermath is devastating: reduced heart contractility, heart cell death, and heart failure. Contributing to these detrimental changes is a signaling molecule, G protein-coupled receptor kinase 2 (GRK2), which following ischemia accumulates in mitochondria, the energy-producing powerhouses of cells.

The Veterans Health Administration (VHA) is the largest integrated health care system in the United States, providing care at 1,243 health care facilities, including 172 VA Medical Centers and 1,062 outpatient sites. Many of the 9 million veterans enrolled in the VA healthcare program will, at some point, have to decide whether to seek care at a VA or non-VA facility.

People with diabetes and followers of diets based on the glycemic index (GI) can enjoy dried fruits knowing they do not cause a blood sugar spike compared to starchy foods such as white bread, suggests a study published in the journal Nutrition and Diabetes.

The results of the study also suggest there's potential for food manufacturers to develop low GI foods with reformulations that include dried fruit, say Dr. John Sievenpiper of Toronto's St. Michael's Hospital and researcher Cyril Kendall of the hospital's Clinical Nutrition and Risk Factor Modi?cation Centre.

Sophia Antipolis, 11 December 2018: Women are being urged to call an ambulance immediately if they have heart attack symptoms, following research showing they wait longer than men to get help. The study is published today in European Heart Journal: Acute Cardiovascular Care, a publication of the European Society of Cardiology (ESC).1