Body

What The Study Did: Photographs of 24 men before and after facial cosmetic surgery were part of this survey study to examine whether surgery was associated with perceived changes in attractiveness, masculinity and a variety of personality traits.

For a patient, a diagnostic error can mean the difference between life and death. While estimates vary, likely more than 100,000 Americans die or are permanently disabled each year due to medical diagnoses that initially miss conditions or are wrong or delayed.

A QUT observational study of electric scooter riding in central Brisbane has found nearly half of shared e-scooters were being ridden illegally.

The research has identified the need to ensure that helmets were available for shared e-scooter riders, and called for further research into whether bicycle helmet standards are adequate for e-scooters.

Mitosis is the process by which the genetic information encoded on chromosomes is equally distributed to two daughter cells, a fundamental feature of all life on earth. Scientists led by Alexander Dammermann at the Max Perutz Labs, a joint venture of the University of Vienna and the Medical University of Vienna, now examine how centrioles contribute to this process. The findings, published in "Developmental Cell", help to elucidate the function of these tiny cellular structures in mitosis.

The German Act on the Reform of the Market for Medicinal Products (AMNOG) was introduced in 2011 to regulate the early benefit assessment of new drugs. More than half of the drugs that have entered the market in Germany since then have emerged from these assessments without any proven added benefit. In a publication in the British Medical Journal using the first 216 assessments, researchers from the Institute for Quality and Efficiency in Health Care (IQWiG) examine the reasons for this sobering result and develop suggestions for improvements in drug development.

The idea of genetically modifying a patient's own immune cells and deploying them against infections and tumors has been around since the 1980s. But to this day modified T cells are still not as effective as natural T cells and have been only been of limited clinical value. Using the new CRISPR-Cas9 gene editing tool, a team at the Technical University of Munich (TUM) has now engineered T cells that are very similar to physiological immune cells.

Pelvic pain associated with endometriosis often becomes chronic and can persist (or recur) following surgical and hormonal interventions. According to results published in Regional Anesthesia & Pain Medicine, treating pelvic floor muscle spasm with botulinum toxin may relieve pain and improve quality of life. The study was conducted by scientists at the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.

Researchers at the University of Oxford, in collaboration with colleagues from Hannover Medical School and Martin-Luther-University Halle-Wittenberg, have discovered the specific gene mutations that are required for the development of leukaemia in children with Down's syndrome. Children with Down's syndrome have a 150-fold increased risk of myeloid leukaemia, and while some of the genetic causes of this have been previously established, this is the first study to identify a wide range of mutations and how they functionally interact to lead to leukaemia.

Riley Tedrow, PhD, a medical entomologist at Case Western Reserve University School of Medicine, has uncovered new findings about malaria transmission in Madagascar.

This clear, gooey substance, which is naturally produced by the human body, has been popularized by cosmetic and skin care products that promote healthier, plumper and more supple skin. Also recognized for its abilities to speed up wound healing, reduce joint pain from osteoarthritis, and relieve dry eye and discomfort, a neuroscientist at Florida Atlantic University's Brain Institute (I-BRAIN) and Schmidt College of Medicine, has discovered a novel mechanism and role in the brain for hyaluronic acid.

A research team headed by scientists at University of California San Diego School of Medicine and the Ludwig Institute for Cancer Research at UC San Diego has identified an enzyme involved in remodeling the plasma membrane of multiple cancer cell types that is critical to both survival of tumors and their uncontrolled growth.

The finding, published in the July 11, 2019 issue of Cell Metabolism, suggests a potential target for new drugs.

Heritable Genome Editing in a Global Context: National and International Policy Challenges

Achim Rosemann, Adam Balen, Brigette Nerlich, Christine Hauskeller, Margaret Sleeboom-Faulkner, Sarah Hartley, Xinqing Zhang, and Nick Lee

BOSTON - A new study by scientists at Massachusetts General Hospital (MGH) offers clues about how to prevent inflammation of brain tissue, which promotes Alzheimer's disease (AD). The findings of this study online now and appearing in the September 4, 2019 print issue of the journal Neuron, could contribute to the development of new therapies for AD.

The prevalence of anal high-grade squamous intraepithelial lesions (HSIL), which precede anal cancer, is much higher in women living with HIV than previously reported, a multi-site, national study involving hundreds of patients has found. Conducted by researchers from the AIDS Malignancy Consortium, a National Cancer Institute-supported clinical trials group, the results call for new strategies to be developed for wider screening of women living with HIV, who have disproportionally higher rates of anal cancer compared to the general population of women.

BOSTON, MA - Patients over age 50 who underwent an all inside arthroscopic repair technique had lower rates of subsequent total knee surgery than a similar group that was only observed, according to research presented at the American Orthopedic Society of Sports Medicine Annual Meeting today.

Dr. Jason L. Dragoo from Stanford Medicine in Redwood City, Calif., and his team of researchers followed 48 patients over age 50 who were diagnosed with a meniscal root tear. The meniscus is the spongy cartilage that provides cushion in the knee.