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Thirteen patients with OXA-48-producing Klebsiella pneumoniae ST392 have been reported by Sweden and Norway between January and April 2018 - all returning travellers with prior hospital admission in Gran Canaria, Spain. Whole genome sequencing showed tight clustering between the bacterial isolates from the cases.

According to ECDC's risk assessment published today, the risk for individual travellers to acquire OXA-48-producing K. pneumoniae ST392 of the Gran Canaria cluster without healthcare contact is very low.

Cold Spring Harbor, NY - In cancer cells, genetic errors wreak havoc. Misspelled genes, as well as structural variations -- larger-scale rearrangements of DNA that can encompass large chunks of chromosomes -- disturb carefully balanced mechanisms that have evolved to regulate cell growth. Genes that are normally silent are massively activated and mutant proteins are formed. These and other disruptions cause a plethora of problems that cause cells to grow without restraint, cancer's most infamous hallmark.

New research published in Experimental Physiology has indicated potential differences in heart health benefits of exercise intensity in teenagers. Teenage years are an important stage of life, with research suggesting it is a time during which heart diseases start to develop. These findings indicate that teenagers who participate in high intensity exercise have lower blood pressure. This may lead to a lower risk of developing heart disease later in life, but this requires confirmation with further research.

Boston, MA -- Cancer immunotherapies and targeted therapy have revolutionized how clinicians take care of patients with advanced skin cancer and have led to long lasting treatment responses for many of them. However, little is known about the survival impact of these therapies for a substantial group of patients. Melanoma patients with cancer that has spread to the brain have been excluded or underrepresented in clinical trials of immunotherapies due to concerns about whether such drugs can cross the blood-brain barrier or will interfere with other forms of treatment.

Sophia Antipolis, 12 July 2018: The more you smoke, the greater your risk of a heart rhythm disorder called atrial fibrillation. That's the finding of a study published today in the European Journal of Preventive Cardiology, a European Society of Cardiology (ESC) journal.(1)

The study found a 14% increase in the risk of atrial fibrillation for every ten cigarettes smoked per day. There was a linear dose-response relationship, meaning that the risk increased with each additional cigarette smoked.

Nearly a third of American adults have high blood pressure, also known as hypertension, putting them at higher risk for heart attacks, strokes, and death. A recent estimate from the Centers for Disease Control reports that high blood pressure--and the many conditions associated with it--contribute to over 400,000 deaths and cost the nation more than $40 billion each year.

A study of women giving birth in Massachusetts found a higher level of opioid use disorder than have studies conducted in other states. In a paper published in the journal Obstetrics & Gynecology, the research team - consisting of investigators from the Mass.

Contact with greenspace is known to have beneficial effects for mental health. A new study by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation, suggests that it may also play a positive role against cognitive decline in elderly. In particular, this research published in Environmental Health Perspectives shows that the loss in cognitive functions expected as part of the ageing process is slightly slower in people who live in greener neighbourhoods.

Peer-reviewed? Yes

Type of evidence: Observational

Subjects: People

Adopting new guidelines for high blood pressure (hypertension) would dramatically increase the number of people labeled as having the condition and being recommended for drug treatment, finds a study published by The BMJ today.

The findings show that, if the guidelines were introduced in the US and China, more than half of those aged 45-75 years in both countries would be considered hypertensive.

Peer-reviewed? Yes

Type of evidence: Observational

Subjects: People

Researchers report no increased risk of womb cancer or invasive breast cancer after assisted reproduction in a study of over 250,000 British women published by The BMJ today.

Small increased risks of non-invasive breast and ovarian tumours were found, but the researchers say these results may not be due to the treatment itself and require further investigation.