Body

Two in three hospitalized seniors are prescribed drugs that should be avoided by older adults, increasing the risk of injury and adverse drug reactions. Improving hospital prescribing practices can reduce the frequency of inappropriate medications and resulting harm, according to a new study led by McGill University researchers.

PHILADELPHIA -- Painful gallstones are common during pregnancy. The pain can be intense, coming on suddenly, increasing and often radiating to the back. When gallstones cause inflammation of the gallbladder, a condition called cholecystitis, the symptoms can worsen, with fever nausea and vomiting in addition to the pain. Surgical removal of the gallbladder is the most effective treatment, but surgery during pregnancy is often feared and at times postponed.

Researchers at Uppsala University have described the presence, throughout the human body, of the enzyme ACE2. This is thought to be the key protein used by the SARS-CoV-2 virus for host cell entry and development of the disease COVID-19. In contrast to previous studies, the study shows that no or very little ACE2 protein is present in the normal respiratory system. The results are presented in Molecular Systems Biology.

More than 70 million people worldwide suffer from glaucoma, a condition that causes a build-up of fluid and pressure inside the eye and can eventually lead to blindness. Treatment options have traditionally included eye drops to reduce the fluid the eye produces or surgery to unclog the eye's drainage.

Amsterdam and Costa Mesa, CA, August 5, 2020 - As a person's weight goes up, all regions of the brain go down in activity and blood flow, according to a new brain imaging study in the Journal of Alzheimer's Disease.

Equipped with naloxone and a smartphone app, community members can save lives in the fight against America's opioid crisis, according to a paper from researchers at Drexel University's Dornsife School of Public Health and colleagues published this week in The Lancet journal EClinicalMedicine.

In a paper published in the journal Cancer Research, professor Levi Waldron, post-doctoral fellow Ludwig Geistlinger, and colleagues at the Institute for Implementation Science in Population Health (ISPH) at the CUNY Graduate School of Public Health and Health Policy (CUNY SPH) provide new insights into how ovarian cancer grows and evolves within a person.

A survey of Central American migrants traveling through Mexico on their way to the United States found that 74 percent of them experienced a degree of food insecurity, ranging from having only one meal to no food at all for one day or longer. Factors associated with more severe food insecurity include more days in active transit, and the experience of illness by the migrant or their travel companion.

B cells are white blood cells that develop to produce antibodies. These antibodies, or immunoglobulins, can bind to harmful foreign particles (such as viruses or disease-causing bacteria) to stop them invading and infecting the body's cells. Each B cell carries an individual B cell receptor (BCR) which determines which particles it can bind, rather like each lock accepts a different key. There are many millions of B cells with different receptors in the body.

Computational modeling has provided new insights into the heart's vascular system, a complex and mechanically demanding system that remains poorly understood.
Researchers from the Oden Institute for Computational Engineering and Sciences at the University of Texas at Austin and Iowa State University used computational modeling techniques to enable accurate visualizations of valve behavior for the first time.

The COVID-19 pandemic has had detrimental effects on global infrastructure sectors, including economic, political, health care, education and research systems, and there is still no definitive treatment strategy for the disease. A team of scientists, including VCU Massey Cancer Center researcher Masoud Manjili, D.V.M., Ph.D., conducted a comprehensive analysis of worldwide COVID-19 data to identify key strategies moving forward to develop effective therapeutics.

Contrary to previous media reports, a new study led by Vanderbilt University Medical Center researchers finds that Medicare Part D prescription drug insurance plans largely favor generic drugs over brand-name counterparts.

A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been available online since August 4, 2020, in the 4th issue of Mendeleev Communications journal.

(Boston)-- Bisphosphonates (a class of drugs that prevent the loss of bone density and used to treat osteoporosis and similar diseases) appear to be safe and beneficial for osteoarthritis patients.

Osteoarthritis (OA) is the most common form of arthritis and a leading cause of disability worldwide with more than 300 million suffering with the condition, yet there are no effective treatments to stop the disease or its progression. One of the lesions in OA that causes pain and progression of the structural pathology of the disease are bone marrow lesions.

WASHINGTON - The Center for Justice Research at Texas Southern University and the Black Public Defender Association today released "Save Black Lives: A Call for Racially-responsive Strategies and Resources for the Black Community during the COVID-19 Pandemic," a comprehensive report that details why public health responses and strategies to address COVID-19 must be centered around race and the criminal legal system.