A team led by a Baylor University researcher has published a breakthrough article that provides a better understanding of the dynamic process by which sunlight-induced DNA damage is recognized by the molecular repair machinery in cells as needing repair.
Adults with HIV are more likely to continue life-saving treatments if their primary health care providers show respect, unconditional empathy without judgement and demonstrate an ability to partner with patients in decision making to address their goals, a Rutgers study finds.
The systematic review appears in the Joanna Briggs Institute Database of Systematic Reviews and Implementation Reports.
New York (July 11, 2019)--As members of the House Committee on Energy & Commerce move to debate, amend, and revise a host of important health proposals, the American Geriatrics Society (AGS) again pledged enthusiastic support for one of the Committee's most important bills under consideration: The Educating Medical Professionals and Optimizing Workforce Efficiency and Readiness (EMPOWER) for Health Act of 2019 (H.R. 2781).
Seeking to improve upon existing checkpoint inhibitor therapies, scientists have developed a common checkpoint inhibitor (anti-PD-L1) in a nanoparticle formulation, which were activated specifically at tumor sites in mouse models of cancer. Their approach intends to prevent the immune system from becoming tolerant of tumors - which occurs in 30% of all cancer patients - and could help avoid the toxic off-target effects observed during the use of standard antibody checkpoint inhibitors.
What The Study Did: Called a systematic review and meta-analysis, this study combined the results of 26 studies to examine the cognitive and motor development of infants and children exposed to opioids prenatally.
What The Study Did: This study (called a systematic review and meta-analysis) combined the results of 21 studies to summarize the overall association between being born preterm or low birth weight and later social outcomes as adults, such as ever having a romantic partnership, having sex or becoming a parent, as well as the quality of romantic partnerships and friendships.
The tobacco industry's court-ordered anti-smoking advertisements reached just 40.6% of U.S. adults and 50.5% of current smokers in 2018, according to new research from The University of Texas MD Anderson Cancer Center. Exposure to the advertisements was even lower among certain ethnic and socioeconomic subgroups historically targeted by tobacco industry marketing.
Cells from the rare individuals who naturally control HIV infection have been the focus of investigation for nearly 15 years with the aim of elucidating their specific features. Following research on the ANRS CO21 CODEX and CO6 PRIMO cohorts, scientists from the Institut Pasteur have described the characteristics of CD8 immune cells in these "HIV controller" subjects. The unique antiviral power of these immune cells can be attributed to an optimal metabolic program that confers persistence and the ability to react effectively against infected cells.
Immune checkpoint blockade (ICB) therapy using the antibody that combats the programmed cell death ligand 1 (PD-L1) shows great potential and is causing a revolution in clinical cancer management. Unfortunately, only a subset of treated patients responds to current ICB therapies, likely due to the immunological tolerance of tumors. Therefore, developing a practical strategy to combat this immunological tolerance and amplify ICB therapies has become a priority.
Root canal work is not as bad as people think when compared to other dental procedures. Self-reporting of their dental health suggests that patients find the procedure no worse than other dental work which overturns the popular belief that root canal work is the most unpleasant dental treatment.
Dr Tallan Chew, postgraduate student, Adelaide Dental School, University of Adelaide co-authored the study.
People with the same lifespan do not necessarily have the same quality of life. As we live longer, extending quality of life -- "healthspan" -- is gaining importance. Scientists at the Okinawa Institute of Science and Technology Graduate University (OIST) have discovered a gene linked with healthy ageing in the roundworm C. elegans, shedding light on the genetics of healthspan.
Singapore, 7 July 2019 - Functional regions within the brain become less distinct and inter-connected in the elderly over time, especially in those networks related to attention span and cognition. The finding, published by researchers at Duke-NUS Medical School in The Journal of Neuroscience, adds to current understanding of longitudinal decline in brain network integrity associated with ageing.
A new study finds that trends in colonoscopy rates did not fully align with the increase in colorectal cancer (CRC) in younger adults, adding to evidence that the rise in early onset CRC is not solely a result of more detection. The study is published early online in the Journal of Medical Screening.
The number of syphilis cases has been consistently going up across Europe since 2010, mostly affecting men who have sex with men living in urban areas. In 2017, notification rates reached an all-time high in the EU/EEA countries with more than 33 000 reported cases. An in-depth ECDC study describes the factors behind this increase and outlines the evidence-based options for public health control of syphilis, including case finding and management as well as educational activities.
HERSHEY, Pa. -- Preventing a protein from doing its job may keep a certain type of ovarian cancer cell from growing and dividing uncontrollably in the lab, according to a new study from Penn State College of Medicine.
In a study with cell cultures, the researchers identified the protein as a potential therapeutic target for high-grade serous ovarian cancer cells. Approximately 70% of patients with this type of ovarian cancer relapse with chemo-resistant disease, increasing the need for new approaches to treatment.