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BOSTON (Aug. 6, 2020)--Researchers at Tufts University School of Medicine and Tufts Graduate School of Biomedical Sciences have discovered neural mechanisms in mice specific to females that can shift estrogen from playing a protective role in glucose metabolism to one that is disruptive. The authors of the study, published online in the Proceedings of the National Academies of Sciences (PNAS), hypothesize that the metabolic "switch" mediated by estrogen may provide clues to the increased risk of insulin resistance and diabetes among post-menopausal women.

Beginning in March, as COVID-19 cases surged in various states in the U.S., the COVID-19 Pandemic Breast Cancer Consortium released recommendations that operations for ductal carcinoma in situ (DCIS) be deferred due to the pandemic. DCIS, which goes by many names including "stage 0" breast cancer, is a non-invasive form of cancer that begins in the milk ducts and is generally surgically excised. In approximately one in five cases, surgeons may find evidence of invasive cancer during surgery.

WASHINGTON (Aug. 6, 2020) -- George Washington University (GW) researchers found five biomarkers, medical indicators found in the blood, associated with higher odds of clinical deterioration and death in COVID-19 patients. Published in Future Medicine, these findings will help physicians better predict outcomes for COVID-19 patients in the U.S.

Reston, VA--A new alpha-radioimmunotherapy, 212Pb-anti-CD38, has proven effective in preventing tumor growth and increasing survival in multiple myeloma tumor-bearing mice, according to new research published in the July issue of the Journal of Nuclear Medicine. Given the long half-life, central production and worldwide distribution of 212Pb-anti-CD38, researchers have determined that the α-radioimmunotherapy is not only effective but also clinically feasible as a multiple myeloma treatment.

A pre-clinical study led by scientists at Cincinnati Children's demonstrates that in mice the drug barasertib reverses the activation of fibroblasts that cause dangerous scar tissue to build up in the lungs of people with idiopathic pulmonary fibrosis (IPF).

The Gerontological Society of America's highly cited, peer-reviewed journals are continuing to publish scientific articles on COVID-19, and all are free to access. The following were published between July 7 and August 1; all are free to access:

Leesburg, VA, August 6, 2020--An "Original Research" article published in ARRS' American Journal of Roentgenology (AJR) concluded that the accuracy of breast cancer diagnosis via diffusion-tensor imaging (DTI) was equivalent both before and after the administration of a gadolinium-based contrast agent (GBCA), despite a value change in DTI parameters.

AURORA, Colo. (Aug. 6, 2020) - A non-hormonal therapy to treat hot flashes and other symptoms associated with menopause was found to be effective in a recent clinical trial, according to a published study by a team of researchers including faculty from the University of Colorado School of Medicine.

Fezolinetant, an oral, non-hormone therapy in clinical development, offers relief for hot flashes and night sweats, which are the most common menopause-associated symptoms for which women seek treatment. About 80 percent of American women experience these symptoms.

A new study has found that HIV screening every three months compared to annually will improve clinical outcomes and be cost-effective among high-risk young men who have sex with men (YMSM) in the United States. The report, led by researchers at the Massachusetts General Hospital (MGH), is being published online in Clinical Infectious Diseases.

PHILADELPHIA--The majority of patients who followed an "Enhanced Recovery After Surgery" (ERAS) protocol did not need opioids for pain management at multiple time points following elective spinal and peripheral nerve surgery. The findings come from an expanded analysis and study from researchers in the Perelman School of Medicine at the University of Pennsylvania, published in Pain Medicine.

WASHINGTON (Aug. 5, 2020) -- Genetic modifier HDAC6 was found to control tumor growth and halt metastasis in triple-negative breast cancer in vivo, according to a new study published in the top-tier journal Cancer Research by investigators at the George Washington University (GW) Cancer Center.

Immunotherapy - the use of drugs to stimulate one's own immune system to recognize and destroy cancer cells - has been wildly successful in melanoma and other cancers. However, it has been less effective in breast cancer.

What The Study Did: Characteristics and response to treatment of persistent radiation-induced hair loss in patients with primary central nervous system tumors or head and neck cancer were examined in this observational study.

Authors: Mario E. Lacouture, M.D., of Memorial Sloan Kettering Cancer Center in New York, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamadermatol.2020.2127)

What The Study Says: Practice patterns for common ocular complaints during the initial stage of the COVID-19 pandemic are reported in this observational study among comprehensive U.S. ophthalmology practices.

Authors: Ajay E. Kuriyan, M.D., of Mid Atlantic Retina, Wills Eye Hospital, Thomas Jefferson University in Philadelphia, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

Gastric cancer is the third leading cause of cancer death worldwide, accounting for over 1,000,000 new cases and nearly 800,000 deaths per year. The poor prognosis of gastric cancer is largely due to the difficulty in early diagnosis of peritoneal metastasis.

Separation and characterization of cancer cells are essential for early diagnosis of peritoneal metastasis. However, due to the low content of cancer cells in patients' peritoneal lavages, traditional detection methods lack sensitivity and cannot satisfy clinical demand.

BOSTON - A paper published today in the Journal of the American Geriatrics Society reported results of an initiative designed to enhance implementation of hospital mobility programs aimed at improving quality of care and outcomes for older patients. Sharon K.