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Assessing the current and future impact of biologics on pediatric asthma

Eurekalert - 12 hours 58 min ago
Researchers have performed a comprehensive review of the current state and future potential of using biologic medications to treat asthma in children.
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The gods of small things

Eurekalert - 12 hours 58 min ago
On the outside, the cluster made of 55 copper and aluminum atoms looks like a crystal, but chemically it has the properties of an atom. The heterometallic superatom which chemists of the Technical University of Munich have created provides the prerequisites for developing new, more cost-effective catalysts.
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Bacteria's password for sporulation hasn't changed in 2.7 billion years

Eurekalert - 12 hours 58 min ago
When it comes to changing their passwords, bacteria are just as bad as you and me -- maybe even worse. A Carnegie Mellon University research team has found that despite 2.7 billion years of evolution, bacteria are still using the same 'password' to initiate the process for making spores. Their findings were published in the September issue of PLOS Genetics.
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Two studies describe improved approach to bone marrow transplant

Eurekalert - 12 hours 58 min ago
Two recent studies in the journal Leukemia present a new approach for bone marrow donation and transplant that preclinical laboratory tests suggest could make the life-saving procedure safer and more effective for patients. Researchers report the studies demonstrate that use of an experimental drug called CASIN in laboratory mice results in higher efficiency when harvesting blood stem cells from donors and less toxicity in transplant recipients.
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Study finds that a lifestyle intervention may mitigate PFAS-related weight gain

Eurekalert - 12 hours 58 min ago
A new study finds that perfluoroalkyl and polyfluoroalkyl substances (PFASs) are associated with increases in weight, but exercise and diet may reduce the obesogenic effects of these environmental contaminants. The study, entitled Association of Perfluoroalkyl and Polyfluoroalkyl Substances with Adiposity, led by researchers from the Harvard Pilgrim Health Care Institute and the Harvard T.H Chan School of Public Health (HSPH) was published on Aug. 31 in JAMA Network Open.
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Identical driver gene mutations found in metastatic cancers

Eurekalert - 12 hours 58 min ago
Driver genes in different metastases from the same patient are remarkably similar, providing optimism for the success of future targeted therapies, according to a published study by Science.
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Study shows value of breast cancer patients seeking second opinions

Eurekalert - 12 hours 58 min ago
In a recent MUSC Hollings Cancer Center study on the value of a second opinion for breast cancer patients, researchers concluded that a review by a tumor board at an NCI-Designated Cancer Center changed the diagnosis for 43 percent of the patients.
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Diversity in the brain -- how millions of neurons become unique

Eurekalert - 12 hours 58 min ago
How is it possible that so many different and highly specific neurons arise in the brain? A mathematic model developed by researchers from the University of Basel's Biozentrum demonstrates that different variants of genes enable such a random diversity. The scientists describe in Cell Reports that despite countless numbers of newly formed neurons, the genetic variants equip neurons individually and precisely for their specific function.
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New way of determining treatment for staph infections cuts antibiotic use

Eurekalert - 12 hours 58 min ago
Using a clinical checklist to identify eligible patients, doctors were able to shorten the antibiotic duration for patients with uncomplicated staphylococcal bloodstream infections by nearly two days, Duke Health researchers report.
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New Tourette disorder genes come to light

Eurekalert - 12 hours 58 min ago
In the largest DNA sequencing study of Tourette Disorder (TD) to date, UC San Francisco researchers and their collaborators have unearthed new data suggesting a potential role for disruptions in cell polarity in the development of this condition.
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Sun exposure gets personal with wearable UV sensors

Eurekalert - 12 hours 58 min ago
RMIT researchers have developed a UV active ink that changes color when exposed to different types of UV rays, providing personalized exposure readings based on skin type.
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Health data breaches on the rise

Eurekalert - 12 hours 58 min ago
The ongoing transition to electronic health records may increase data breaches involving patient records. An analysis of reported breaches of health data from 2010 through 2017 found that except for 2015, the number of breach reports increased each year. During this time there were 2,149 breaches comprising a total of 176.4 million records. The most common entity breached was a health care provider, with 1,503 breaches (70 percent) compromising a total of 37.1 million records.
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What is long-term risk of appendicitis reoccurring in patients treated with antibiotics?

Eurekalert - 12 hours 58 min ago
About 60 percent of patients with uncomplicated acute appendicitis who were initially treated with antibiotics did not undergo appendectomy in five years in a follow-up to a randomized clinical trial. The clinical trial included 273 patients who had an appendectomy and 257 patients initially treated with antibiotics for uncomplicated acute appendicitis.
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Study reveals patterns in STEM grades of girls versus boys

Eurekalert - 12 hours 58 min ago
A new study, led by UNSW Sydney PhD student Rose O’Dea, has explored patterns in academic grades of 1.6 million students, showing that girls and boys perform very similarly in STEM - including at the top of the class.
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Mass. General study analyzes numbers, trends in health care data breaches nationwide

Eurekalert - 12 hours 58 min ago
Health plans -- entities that cover the costs of medical care -- accounted for the greatest number of patient records breached over the past seven years, according to an analysis of US health care data conducted by two Massachusetts General Hospital physicians.
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Immune cell pruning of dopamine receptors may modulate behavioral changes in adolescence

Eurekalert - 12 hours 58 min ago
A study by MassGeneral Hospital for Children researchers finds that the immune cells of the brain called microglia play a crucial role in brain development during adolescence, but that role is different in males and females.
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Skin wounds in older mice are less likely to scar

Eurekalert - 12 hours 58 min ago
Researchers have discovered a rare example in which the mammalian body functions better in old age. A team at the University of Pennsylvania found that, in skin wounds in mice, being older increased tissue regeneration and decreased scar formation. The same findings were confirmed in studies of human tissue. Their findings publish on Sept. 25 in the journal Cell Reports.
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Brigatinib becomes potential new first-line option for ALK-positive non-small lung cancer

Eurekalert - 12 hours 58 min ago
'In 2017, alectinib, another next generation ALK-inhibitor, showed that it was superior to crizotinib in the first-line setting through the ALEX trial and now, in 2018, brigatinib is set to join alectinib as a 1st line option for ALK positive lung cancer,' said D. Ross Camidge, M.D., Ph.D., Joyce Zeff Chair in Lung Cancer Research at the University of Colorado Cancer Center and the lead author of ALTA-1L.
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The crazy dance of falling knots

Eurekalert - 12 hours 58 min ago
Can the topology of microobjects influence the way they move in a fluid? Experiments and simulations of Polish and Swiss researchers published in the Physical Review Letters show that the dynamics of elastic chains settling in a fluid depends on the way they are knotted. The settling chains form flat, toroidal structures composed of several intertwined loops, which swirl around each other. The study is important for the proper interpretation of sedimentation and centrifugation experiments of biomolecules.
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Screening using body mass index alone may miss every second preschooler with excess stomach fat

Eurekalert - 12 hours 58 min ago
When assessing whether preschoolers are overweight, health professionals should use other measures such as waist-to-height ratio in addition to the body mass index (BMI). A study published in the Springer Nature-branded journal Pediatric Research shows that this is because measuring the BMI of younger children often fails to identify those with excess stomach fat and possible associated health problems.
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