Body

For the past decade, scientists have been pursuing cancer treatments based on RNA interference — a phenomenon that offers a way to shut off malfunctioning genes with short snippets of RNA. However, one huge challenge remains: finding a way to efficiently deliver the RNA.

Most of the time, short interfering RNA (siRNA) — the type used for RNA interference — is quickly broken down inside the body by enzymes that defend against infection by RNA viruses.

PASADENA, Calif.—Bacteria have evolved different systems for secreting proteins into the fluid around them or into other cells. Some, for example, have syringe-like exterior structures that can pierce other cells and inject proteins. Another system, called a type VI secretion system, is found in about a quarter of all bacteria with two membranes. Despite being common, researchers have not understood how it works.

Ancient manuscripts written by Arabic scholars can provide valuable meteorological information to help modern scientists reconstruct the climate of the past, a new study has revealed. The research, published in Weather, analyses the writings of scholars, historians and diarists in Iraq during the Islamic Golden Age between 816-1009 AD for evidence of abnormal weather patterns.

For the first time, Massachusetts General Hospital (MGH) researchers have isolated egg-producing stem cells from the ovaries of reproductive age women and shown these cells can produce what appear to be normal egg cells or oocytes. In the March issue of Nature Medicine, the team from the Vincent Center for Reproductive Biology at MGH reports the latest follow-up study to their now-landmark 2004 Nature paper that first suggested female mammals continue producing egg cells into adulthood.

Researchers have identified an elusive gene responsible for Thrombocytopenia with Absent Radii (TAR), a rare inherited blood and skeletal disorder. As a result, this research is now being transformed into a medical test that allows prenatal diagnosis and genetic counselling in affected families.

The team used genetic sequencing to discover that TAR results from low levels of the protein called Y14. They found that the syndrome occurs by a unique inherited mechanism.

MAYWOOD, Ill. – In a study published in Nature Medicine, Loyola researchers report on a promising new technique that potentially could turn immune system killer T cells into more effective weapons against infections and possibly cancer.

Sophia Antipolis, 25 February 2012: A large population-based study has found that lung function and obstructive airway diseases are strongly and independently associated with increased risk of heart failure. Importantly, say the investigators, this association was even evident in never-smokers and was still evident after adjustment for smoking status and number of years smoking. This, they add, indicates "that our results are not primarily confounded by smoking".

February 23, 2012 -- One of the first large-scale genomic studies conducted in a developing country has discovered genetic variants that elevate the risk for skin lesions in people chronically exposed to arsenic. Genetic changes found near the enzyme for metabolizing the chemical into a less toxic form can significantly increase an individual's risk for developing arsenic-related disease.

A UCLA-led group of researchers tracing disparities in life expectancy between blacks and whites in the U.S. has found that white males live about seven years longer on average than African American men and that white women live more than five years longer than their black counterparts.

Pediatric cardiology researchers and clinicians from almost 50 centers from across the U.S. and around the world are gathering at the Cardiology 2012 Conference sponsored by The Children's Hospital of Philadelphia on Feb. 22-26 in Orlando, Fla. The news briefs below summarize 11 research abstracts selected by the conference organizers as featured presentations. The researchers leading these presentations comprise 6 physicians and 5 nurses.

New Early Warning Algorithm Detects Children's Early Cardiac Deterioration Before Inpatient Arrest

Boulder, Colorado, USA - Linear dunes, widespread on Earth and Saturn's moon, Titan, are generally considered to have been formed by deposits of windblown sand. It has been speculated for some time that some linear dunes may have formed by "wind-rift" erosion, but this model has commonly been rejected due to lack of sufficient evidence. Now, new research supported by China's NSF and published this week in GSA BULLETIN indicates that erosional origin models should not be ruled out.

Prehistoric Eurasian nomads are commonly perceived as horse riding bandits who utilized their mobility and military skill to antagonize ancient civilizations such as the Chinese, Persians, and Greeks. Although some historical accounts may support this view, a new article by Dr. Michael Frachetti (Washington University, St. Louis) illustrates a considerably different image of prehistoric pastoralist societies and their impact on world civilizations more than 5000 years ago.

The gold standard for nanotechnology is nature's own proteins. These biomolecular nanomachines – macromolecules forged from peptide chains of amino acids - are able to fold themselves into a dazzling multitude of shapes and forms that enable them to carry out an equally dazzling multitude of functions fundamental to life. As important as protein folding is to virtually all biological systems, the mechanisms behind this process have remained a mystery. The fog, however, is being lifted.

Patients with heart disease who took cholesterol-lowering statins were significantly less likely to develop depression than those who did not, in a study by Mary Whooley, MD, a physician at the San Francisco VA Medical Center and a professor of medicine at the University of California, San Francisco.

The study was published electronically in the Journal of Clinical Psychiatry (February 21, 2012).

LOS ALAMOS, New Mexico, February 24, 2012—A multinational team of scientists has developed a process for creating glass-based, inorganic light-emitting diodes (LEDs) that produce light in the ultraviolet range. The work, reported this week in the online Nature Communications, is a step toward biomedical devices with active components made from nanostructured systems.