Body

San Diego, Calif. – Each year, phytoplankton blooms known as "red tides" kill millions of fish and other marine organisms and blanket vast areas of coastal water around the world. Though the precise causes of red tides remain a mystery, a team of researchers in the United States and Spain has solved one of the main riddles about these ecological disasters by uncovering the specific mechanism that triggers phytoplankton to release their powerful toxins into the environment.

JUPITER, FL, February 23, 2012 – Although it's widely accepted that inflammation is a critical underlying factor in a range of diseases, including the progression of cancer, little is known about its role when normal cells become tumor cells. Now, scientists from the Florida campus of The Scripps Research Institute have shed new light on exactly how the activation of a pair of inflammatory signaling pathways leads to the transformation of normal breast cells to cancer cells.

CINCINNATI – Scientists have developed a unique compound that in laboratory tests blocks inflammation-causing molecules in blood cells known to fuel ailments like cancer and cardiovascular disease without causing harmful toxicity.

Researchers at the EPFL have identified an important mechanism that could lead to the design of more effective cancer vaccines. Their discovery of a new-found role of the lymphatic system in tumour growth shows how tumours evade detection by using a patient's own immune system.

CHICAGO --- Millions of "good" bacteria exist harmoniously on the skin and in the intestines of healthy people. When harmful bacteria attack, the immune system fights back by sending out white blood cells to destroy the disease-causing interlopers. But how do white blood cells know which bacteria are good and which are harmful?

PROVIDENCE, R.I. -- Adam Levine, M.D., an emergency medicine physician with Rhode Island Hospital and a volunteer physician with International Medical Corps, was deployed to a field hospital near Misurata, Libya, during the conflict there. He and his colleagues cared for over 1,300 patients from both sides of the conflict between June and August 2011.

San Diego, Calif. – HIV has eluded vaccine-makers for thirty years, in part due to the virus' extreme ability to mutate. Physical scientists and clinical virologists from the Massachusetts Institute of Technology (MIT) and the Ragon Institute in Cambridge, Mass., have identified a promising strategy for vaccine design using a mathematical technique that has also been used in problems related to quantum physics, as well as in analyses of stock market price fluctuations and studies of enzyme sequences.

San Diego, Calif. – For snakes, spiders, and other venomous creatures, the "business end," or active part, of a toxin is the area on the surface of a protein that is most likely to undergo rapid evolution in response to environmental constraints, say researchers from Ben Gurion University in Israel. Understanding these evolutionary forces can help researchers predict which part of unstudied toxins will do damage, and may also aid in the design of novel synthetic proteins with tailored pharmaceutical properties.

A small study of Latina women with young children led by researchers at Johns Hopkins Children's Center shows moms value a pediatrician's empathy and warmth far more than their ability to speak Spanish or other conveniences.

A report on the findings is published online Feb. 15 in Maternal and Child Health Journal.

The lead investigator a pediatrics fellow at Johns Hopkins, conducted the research during post-residency training at the University of Michigan as a Robert Wood Johnson Foundation Clinical Scholar.

San Diego, Calif. – When bacteria wage a turf war, some of the combatants have an extra weapon. Certain strains of the bacteria E. coli produce proteins that kill competing E. coli and other like microbes, and researchers from Newcastle University in England have recently discovered something surprising about one of these lethal proteins: even after the toxic folded portion of the protein is removed, the unfolded end is still deadly. The finding may one day help scientists find new, more targeted ways to kill antibiotic-resistant microbes.

EAST LANSING, Mich. — The deaths of at least 13 workers who were refinishing bathtubs have been linked to a chemical used in products to strip surfaces of paint and other finishes.

In the developing world, allocating limited health care resources as effectively and equitably as possible is a top priority.

To address that need, systems engineers at the Georgia Institute of Technology are using computer models to help resource-poor nations improve supply chain decisions related to the distribution of breast milk and non-pharmaceutical interventions for malaria. They are also forecasting what health care services would be available in the event of natural disasters in Caribbean nations.

San Diego, Calif. – Several neurodegenerative diseases – including Alzheimer's and ALS (Lou Gehrig's disease) – are caused when the body's own proteins fold incorrectly, recruit and convert healthy proteins to the misfolded form, and aggregate in large clumps that gum up the works of the nervous system. "For Star Trek fans, this is like the Borg, [a fictional race of cyborgs that abduct and assimilate humans and other species]," says Steven Plotkin, a biophysicist at the University of British Columbia in Vancouver who studies the process of protein misfolding.

San Diego, Calif. – Cigarette smoke has long been considered the main risk factor for heart disease. But new research from Brown University in Providence, R.I., shows that nicotine itself, a component of cigarette smoke, can contribute to the disease process by changing cell structure in a way that promotes migration and invasion of the smooth muscle cells that line blood vessels. In particular, invading cells can remodel structures called podosomes, and this leads to further degradation of vessel integrity.

San Diego, Calif. – In H.G. Wells' classic science-fiction novel, The War of the Worlds, bacteria save the Earth from destruction when the Martian invaders succumb to infections to which humans have become immune through centuries of evolution. If a team led by researchers at Lawrence Berkley National Laboratory's Center for Nanoscale Control of Geologic CO2 (NCGC) has its way, bacteria – with a little assist from science – will help prevent global destruction for real by trapping underground a greenhouse gas, carbon dioxide (CO2 ), that threatens Earth's climate.