Body

NEW YORK, NY (January 23, 2014) — Survivors of breast cancer have a one in six chance of developing breast cancer in the other breast. But a study conducted in mice suggests that survivors can dramatically reduce that risk through treatment with moderate doses of radiation to the unaffected breast at the same time that they receive radiation therapy to their affected breast. The treatment, if it works as well in humans as in mice, could prevent tens of thousands of second breast cancers.

RIVERSIDE, Calif. — In 2009, a borehole drilled at Krafla, northeast Iceland, as part of the Icelandic Deep Drilling Project (IDDP), unexpectedly penetrated into magma (molten rock) at only 2100 meters depth, with a temperature of 900-1000 C. The borehole, IDDP-1, was the first in a series of wells being drilled by the IDDP in Iceland in the search for high-temperature geothermal resources.

AMHERST, Mass. – Introducing a new approach that combines evolutionary and engineering analyses to identify the targets of natural selection, researchers report in the current issue of Evolution that the new tool opens a way of discovering evidence for selection for biomechanical function in very diverse organisms and of reconstructing skull shapes in long-extinct ancestral species.

Cancer isn't a singular disease, even when talking about one tumor. A tumor consists of a varied mix of cells whose complicated arrangement changes all the time, especially and most vexingly as doctors and patients do their best to fight it. Researchers reporting in the Cell Press journal Cell Reports have now developed a tool to help them predict which direction a tumor is most likely to go and how it might respond to chemotherapy.

Working with Yalei Chen, graduate student in cell and developmental biology in the Huck Institutes of the Life Sciences, the researchers found that kinesin motors can not only transport molecules along the tubules, but can redirect the ends of the tubules to enter the proper branch of the dendrite. They report their findings online today (Jan. 23) in Current Biology.

In the laboratory, the researchers grew microtubules under the microscope and used protein engineering to attach a kinesin motor to EB1 -- a protein that binds to the growing end of microtubules.

Baltimore, MD— As all school-children learn, cells divide using a process called mitosis, which consists of a number of phases during which duplicate copies of the cell's DNA-containing chromosomes are pulled apart and separated into two distinct cells. Losing or gaining chromosomes during this process can lead to cancer and other diseases, so understanding mitosis is important for developing therapeutic strategies.

The elusive trigger that allows plants to 'see' the gas nitric oxide (NO), an important signalling molecule, has been tracked down by scientists at The University of Nottingham. It is the first time that a central mechanism for the detection of NO in plants has been identified.

Bigger really is better – at least it was for early prehistoric life.

A NASA research group featuring University of Toronto Mississauga professor Marc Laflamme has helped to explain why some prehistoric organisms evolved into larger animals.

Laflamme, an assistant professor with the Department of Chemical and Physical Sciences, and his colleagues at the Massachusetts Institute of Technology Node of NASA's Astrobiology Institute suggest that height offered a distinct advantage to the earliest forms of multicellular life.

Researchers from Germany have identified the mechanism by which Salmonella infections can reduce the incidence of asthma in mice. The research, which appears ahead of print in the journal Infection and Immunity, opens up new avenues of research that could lead to treatments.

Marine scientists working on the coral reefs of Palau have made two unexpected discoveries that could provide insight into corals' resistance and resilience to ocean acidification.

The team collected water samples at nine points along a transect that stretched from the open ocean, across a barrier reef, into a lagoon, and into the bays and inlets around the Rock Islands of Palau in the western Pacific Ocean.

With each location they found that the seawater became increasingly more acidic as they moved toward land.

CORVALLIS, Ore. – A study of the metabolic effects of omega-3 fatty acids, especially DHA, concludes that these compounds may have an even wider range of biological impacts than previously considered, and suggests they could be of significant value in the prevention of fatty liver disease.

Athens, Ga. – The thymus gland is a critical component of the human immune system that is responsible for the development of T-lymphocytes, or T-cells, which help organize and lead the body's fighting forces against harmful organisms like bacteria and viruses.

The main body of the thymus lies beneath the breastbone in the upper chest. But scientists were surprised several years ago when two teams of researchers discovered that both mice and humans have extra thymus-like glands distributed throughout their necks.

MAYWOOD, Il. – Physical activity significantly extends the lives of male cancer survivors, a new study of 1,021 men has found.

During the period while the men were followed, those who expended more than 12,600 calories per week in physical activity were 48 percent less likely to die than those who burned fewer than 2,100 calories per week.

Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes. The genetic alterations identified in this malignancy could be useful in developing targeted diagnostic tools and treatments for children with the disease. The study, by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues, appeared in the Jan. 23, 2014, issue of the journal Cancer Discovery.

CAMBRIDGE, Mass-- Flexible, layered materials textured with nanoscale wrinkles could provide a new way of controlling the wavelengths and distribution of waves, whether of sound or light. The new method, developed by researchers at MIT, could eventually find applications from nondestructive testing of materials to sound suppression, and could also provide new insights into soft biological systems and possibly lead to new diagnostic tools.