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Penn study confirms no transmission of Alzheimer's proteins between humans

PHILADELPHIA - Mounting evidence demonstrates that the pathological proteins linked to the onset and progression of neurodegenerative disorders are capable of spreading from cell-to-cell within the brains of affected individuals and thereby "spread" disease from one interconnected brain region to another. A new study found no evidence to support concerns that these abnormal disease proteins are "infectious" or transmitted from animals to humans or from one person to another.

Vitamin C supplements linked to kidney stones

New research from Karolinska Institutet in Sweden shows that men who take vitamin C supplements regularly run a higher risk of developing kidney stones. The study, which is published in the scientific periodical JAMA Internal Medicine, did not however observe an increased risk between kidney stones and multivitamins – which contain lower concentrations of vitamin C.

Children with autism at significant risk for feeding problems and nutritional deficits

Healthy eating not only promotes growth and development, but also provides important opportunities for children to socialize during meals. A new, comprehensive analysis of feeding behavior in children with autism spectrum disorders (ASD) indicates that these children are five times more likely to have a feeding problem, including extreme tantrums during meals, severe food selectivity and ritualistic mealtime behaviors.

Early breast cancer diagnosis, survival rates low in rural India

ANN ARBOR—Women in developed countries survive roughly 10 years longer after a breast cancer diagnosis compared to women in poor-to-middle-income countries, a new University of Michigan study suggests.

The report demonstrates the lack of access to good health care faced by women in poor countries, said the study's principal investigator Rajesh Balkrishnan, an associate professor at the U-M schools of Pharmacy and Public Health.

Early diagnosis and sustained treatment were the biggest hurdles and also the main indicators of patient survival, he said.

New study shows that gases work with particles to promote cloud formation

New York, NY—January 30, 2013—Researchers at Columbia Engineering and Georgia Institute of Technology have published a study in the online Early Edition of Proceedings of the National Academy of Sciences (PNAS) showing—for the first time—that certain volatile organic gases can promote cloud formation in a way never considered before by atmospheric scientists. The study will be published the week of February 4, 2013.

Antibody hinders growth of Gleevec-resistant gastrointestinal tumors in lab tests

STANFORD, Calif. - An antibody that binds to a molecule on the surface of a rare but deadly tumor of the gastrointestinal tract inhibits the growth of the cancer cells in mice, according to researchers at the Stanford University School of Medicine.

The effect remains even when the cancer cells have become resistant to other treatments, and the findings may one day provide a glimmer of hope for people with the cancer, known as gastrointestinal stromal tumor, or GIST. The scientists hope to move into human clinical trials of the antibody within two years.

USC scientists design mouse with more human-like immune response

LOS ANGELES — Medical scientists at the University of Southern California (USC) have bred a first-of-its-kind mouse model that possesses an immune response system more like a human's. The discovery makes way for quicker and more cost-effective development of next-generation drugs to treat human diseases like cancer, diabetes and tuberculosis.

Cells predict onset of graft-versus-host disease in men receiving BMTs from female donors

STANFORD, Calif. — Stanford University School of Medicine investigators have identified a clutch of cells that — if seen in a male patient's blood after receiving a brand-new immune system in the form of a bone-marrow transplant from a female donor — herald the onset of chronic graft-versus-host disease, or cGVHD. In this devastating syndrome, the patient's tissues come under a vicious and enduring assault by the transplanted cells.

Researchers pioneer treatment for viral infection common in children

Researchers at Imperial College London have discovered a new way in which a very common childhood disease could be treated.In the first year of life, 65 per cent of babies get infected by Respiratory Syncytial Virus (RSV). This causes bronchiolitis, and is thought to kill nearly 200,000 children every year worldwide.

Scientists turn toxic by-product into biofuel booster

UPTON, NY-Scientists studying an enzyme that naturally produces alkanes -- long carbon-chain molecules that could be a direct replacement for the hydrocarbons in gasoline -- have figured out why the natural reaction typically stops after three to five cycles. Armed with that knowledge, they've devised a strategy to keep the reaction going. The biochemical details -- worked out at the U.S.

Paired genes in stem cells shed new light on gene organization and regulation

CAMBRIDGE, Mass. (February 4, 2013) – Whitehead Institute researchers have determined that DNA transcription, the process that produces messenger RNA (mRNA) templates used in protein production, also runs in the opposite direction along the DNA to create corresponding long noncoding RNAs (lncRNAs). Moreover, the mRNAs and lncRNAs are transcribed coordinately as stem cells differentiate into other cell types. This surprising finding could redefine our understanding of gene organization and its regulation.

Monogamous birds read partner's food desires

New research shows that male Eurasian Jays in committed relationships are able to share food with their female partner according to her current desire.

The behaviour suggests the potential for 'state-attribution' in these birds – the ability to recognise and understand the internal life and psychological states of others.

The research was carried out in Professor Nicola Clayton's Comparative Cognition lab at Cambridge University's Department of Psychology, and is published today in the journal PNAS.

How plants sense gravity -- a new look at the roles of genetics and the cytoskeleton

Gravity affects the ecology and evolution of every living organism. In plants, the general response to gravity is well known: their roots respond positively, growing down, into the soil, and their stems respond negatively, growing upward, to reach the sunlight. But how do plants sense gravity and how do they direct or signal their cells to grow in response to it?

Some cancer mutations slow tumor growth

CAMBRIDGE, MA -- A typical cancer cell has thousands of mutations scattered throughout its genome and hundreds of mutated genes. However, only a handful of those genes, known as drivers, are responsible for cancerous traits such as uncontrolled growth. Cancer biologists have largely ignored the other mutations, believing they had little or no impact on cancer progression.

MU scientists build harness for powerful radiation cancer therapy

Robertson and researchers from Oak Ridge National Laboratory and the School of Medicine at the University of Tennessee in Knoxville used the element "actinium," which is an element known as an "alpha emitter" because it produces alpha particles. As it decays, actinium creates three additional elements that produce alpha particles.