Body

A previously poorly investigated signalling pathway is crucial for the growth and proliferation of prostate cancer cells. An international research team discovered this when studying the enzyme "soluble adenylyl cyclase" that produces the second messenger molecule cAMP. When the scientists inhibited the enzyme, the cancer cell proliferation was suppressed. The team led by Dr.

OAK BROOK, Ill. – The underlying medical conditions facing young adults who undergo computed tomography (CT) exams represent a significantly greater health risk than that of radiation-induced cancer from CT, according to a new study published online in the journal Radiology.

San Diego, CA, February 5, 2013 – Electronic nicotine delivery systems (ENDS), or e-cigarettes, debuted in China in 2003 and have since become available globally, particularly through the Internet. While they resemble traditional tobacco cigarettes, they produce fewer toxins in the vapor for the smoker. Still, these novel products have unknown long-term health and addiction consequences, are of varying nicotine content and delivery, and may appeal to nonusers and youth. ENDS have been banned by health authorities in Canada and Australia.

A team of researchers from Scotland has used a novel 3D printing technique to arrange human embryonic stem cells (hESCs) for the very first time.

It is hoped that this breakthrough, which has been published today, 5 February, in the journal Biofabrication, will allow three-dimensional tissues and structures to be created using hESCs, which could, amongst other things, speed up and improve the process of drug testing.

Mutations which affect the gene ASXL3 cause a novel syndrome similar to Bohring-Opitz syndrome, finds a study published in BioMed Central's open access journal Genome Medicine. This molecular definition distinguishes these children from those with Bohring-Opitz, and other similar syndromes, and highlights a technique able to help define rare diseases.

A chance discovery that sea urchins use Nickel ions to harness carbon dioxide from the sea to grow their exoskeleton could be the key to capturing tonnes of CO2 from the atmosphere.

A new study led by Durham University and BirdLife International, shows that many bird species are likely to suffer under future climate change, and will require enhanced protection of important sites, better management of the wider countryside, and in some of the most extreme cases may need to be physically moved to climatically suitable areas to help them survive.

In order to spot potential predators, adult meerkats often climb to a higher vantage point or stand on their hind legs. If a predator is detected, they use several different alarm calls to warn the rest of the group. New Cambridge research shows that they are more likely to exhibit this behaviour when there are young pups present, suggesting that the predator-scanning behaviour is for the benefit of the group rather than the individual.

Healthy young men who watch TV for more than 20 hours a week have almost half the sperm count of men who watch very little TV, indicates a study published online in the British Journal of Sports Medicine.

Conversely, men who do 15 or more hours of moderate to vigorous exercise every week have sperm counts that are 73% higher than those who exercise little, the findings show.

Semen quality seems to have deteriorated over the past few decades, although it's not clear why, say the authors.

Boston, MA — Men's sperm quality may be significantly affected by their levels of physical activity, according to a new study led by researchers at Harvard School of Public Health (HSPH). They found that healthy young men who were sedentary, as measured by hours of TV viewing, had lower sperm counts than those who were the most physically active.

Having a higher fitness level at midlife seems to be associated with lower hazards of developing Alzheimer disease and other types of dementia later in life.

Between 1970 and 2009, researchers at a community health clinic utilized an exercise treadmill test to assess the baseline fitness levels of 19,458 non-elderly, community-dwelling adults who were in generally good health.

Boston, MA – Having adequate levels of vitamin D during young adulthood may reduce the risk of adult-onset type 1 diabetes by as much as 50%, according to researchers at Harvard School of Public Health (HSPH). The findings, if confirmed in future studies, could lead to a role for vitamin D supplementation in preventing this serious autoimmune disease in adults. The study was published online February 3, 2013 and will appear in the March 1 print edition of the American Journal of Epidemiology.

LA JOLLA, CA – February 4, 2013 – A team led by scientists at The Scripps Research Institute (TSRI) has identified specific cellular events that appear key to lupus, a debilitating autoimmune disease that afflicts tens of millions of people worldwide. The findings suggest that blocking this pathway in lupus-triggering cells could be a potent weapon against the disease.

A group of recipients of cadaver-derived human growth hormone (c-hGH) does not appear to be at increased risk for Alzheimer and Parkinson disease despite their likely exposure to neurodegenerative disease (ND)-associated proteins and elevated risk of infectious prion protein-related disease, according to a report published Online First by JAMA Neurology, a JAMA Network publication.

A high intake of supplemental calcium appears to be associated with an increased risk of cardiovascular disease (CVD) death in men but not in women in a study of more 388,000 participants between the ages of 50 and 71 years, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication.