Body

"By using the powerful X-ray beams created by the synchrotron, we obtained structures of Bax that were really exciting," Dr Czabotar said. "Bax is activated when small protein fragments called BH3-peptides bind to it. We saw that these peptides open up the Bax molecule like a key unlocking a padlock. This unlocked form of Bax can bind to another Bax molecule, which can then form larger Bax complexes that can go on to break up membranes in the cell.

Autism spectrum disorders affect as many as nearly 1 in 88 children, with symptoms ranging from mild personality traits (almost everyone) to severe intellectual disability and seizures (what used to be autism). Understanding the altered genetic pathways is critical for diagnosis and treatment and new work trying to examine which genes are responsible for autism disorders will be presented at the 57th Annual Meeting of the Biophysical Society (BPS), held Feb. 2-6, 2013, in Philadelphia, Pa.

Philadelphia, Pa. – With the discovery of antibiotics, medicine acquired power on a scale never before possible to protect health, save lives, and reduce suffering caused by certain bacteria. But the power of antibiotics is now under siege because some virulent infections no longer respond to antibiotic drugs.

Latest research points to the high risk for mental health problems among staff working in humanitarian organizations in northern Uganda, due in large part to their work environment. A new study by researchers at Columbia's Mailman School of Public Health examined the mental health of 376 Ugandan workers at 21 humanitarian aid agencies and found that a significant number of the staff at these organizations experienced high levels of symptoms for depression (68%), anxiety disorders (53%), and posttraumatic stress disorder (PTSD) (26%), respectively.

Researchers at Moffitt Cancer Center and colleagues at the Mayo Clinic in Rochester, Minn., have developed a novel computer algorithm to easily quantify a major risk factor for breast cancer based on analysis of a screening mammogram. Increased levels of mammographic breast density have been shown in multiple studies to be correlated with elevated risk of breast cancer, but the approach to quantifying it has been limited to the laboratory setting where measurement requires highly skilled technicians.

Philadelphia, Pa. – The shortened daylight of a Maine winter may make for long, dark nights – but it has shone a light on a novel experimental approach to fighting inflammatory breast cancer (IBC), an especially deadly form of breast cancer.

New Rochelle, NY, January 31, 2012—Powerful antisense drugs that target disease-associated genes to block their expression can be used to treat a broad range of diseases. Though antisense therapy has been proven effective, challenges remain in ensuring that the drugs reach their intended targets.

Philadelphia, Pa. – A research team in Japan exploring the functions of messenger ribonucleic acid (mRNA) – a molecule that encodes the chemical blueprint for protein synthesis – has discovered a way to take a close look at the temperature distribution inside living cells. This discovery may lead to a better understanding of diseases, such as cancer, which generate extraordinary intracellular heat.

Philadelphia, Pa. – The texture of breast cancer tissue differs from that of healthy tissue. Using a cutting-edge tissue diagnostic device, a group of researchers in Basel, Switzerland, has determined one key difference: cancerous tissue is a mix of stiff and soft zones, whereas healthy tissue has uniform stiffness. This new finding may one day help improve breast cancer diagnosis and therapy by providing a unique nanomechanical signature of tumor tissue properties that indicates the potential for the cancer to spread.

Philadelphia, Pa. – Microbes exhibit bewildering diversity even in relatively tight living quarters. But when a population is a mix of cooperators, microbes that share resources, and cheaters, those that selfishly take yet give nothing back, the natural outcome is perpetual war. A new model by a team of researchers from Princeton University in New Jersey and Ben-Gurion University in Israel reveals that even with never-ending battles, the exploiter and the exploited can survive, but only if they have room to expand and grow.

In a project that began with the retinal cells of nocturnal animals and has led to fundamental insights into the organization of genomic DNA, researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich show how the nuclear envelope affects nuclear architecture - and gene regulation.

On April 14, 2003 a map of the human genome was completed, ushering in a new era of genetics in medicine with applications that include genetic testing; newborn screening; susceptibility to diseases such as cancer, cardiovascular disease, or psychiatric conditions; screening, diagnosis and monitoring of disease; and treatment planning.

(SACRAMENTO, Calif.) ― A study of more than 12,000 children from emergency departments throughout the country in the Pediatric Emergency Care Applied Research Network (PECARN) has identified seven factors that can help physicians determine the need for a computed tomography (CT) scan following blunt trauma to the abdomen. Because CT scans pose radiation hazards for youngsters, the findings may enable doctors to determine which children do not need to be exposed to such tests after a traumatic injury.

Boston - A study by researchers at the Institute for Aging Research (IFAR) at Hebrew SeniorLife, an affiliate of Harvard Medical School (HMS), has found that dairy intake —specifically milk and yogurt —is associated with higher bone mineral density (BMD) in the hip, but not the spine. Cream, on the other hand, may be associated with lower BMD overall. Published today in the journal Archives of Osteoporosis, these findings suggest that not all dairy products are equally beneficial in promoting bone strength.

Washington, DC, February 1, 2013 – There is general agreement among hospital infection preventionists (IPs) with respect to which practices have weak or strong evidence supporting their use to prevent healthcare-associated infection, according to a new study published in the February issue of the American Journal of Infection Control, the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC).