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A study performed by researchers at the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC) from the Spanish National Research Council (CSIC) in collaboration with Stony Brook University (USA) proposes a new strategy for the development of new drugs based on the inhibition of tyrosine kinase enzymes, molecules that activate and trigger many cellular processes. The results have been published in the Chemistry - A European Journal.

Researchers from Tokyo Medical and Dental University (TMDU) have found that the urinary secretion of uromodulin, a kidney-specific protein, can be increased by the hormone vasopressin via certain signaling pathways. Increasing the urinary secretion of uromodulin may protect against urinary tract infections and kidney stones, while the resulting lower uromodulin levels in kidney cells may help to prevent hypertension and chronic kidney disease.

RUDN University biotechnologists have created a method for detection of bacterial infection in apple, pear, hawthorn and other plants of the Rosaceae family. The test does not require laboratory equipment, the result is ready in 10 minutes. This will allow detecting the disease quickly and prevent the spread of infection.

DNA analysis has revealed the presence of 'Yersinia Pestis' - the pathogen that causes plague - in skeletal remains from individual burials in medieval Cambridgeshire, confirming for the first time that not all plague victims were buried in mass graves. Compassion and care were shown to victims even during traumatic times during past pandemics.

Modelling the financial system as a network is a precondition to understanding and managing the containment of financial crises and the transition to a low-carbon economy. Financial Networks is the scientific discipline that deals with these issues. An article published in the scientific journal Nature Review Physics carries out the first comprehensive review of this field.

An international research consortium, in which Inselspital, Bern University Hospital and the University of Bern participated, has re-assessed and updated the previous classification of metastatic testicular cancer in a comprehensive study. New indicators and a much broader database enabled a more precise classification and more targeted treatments of patients. In addition, the new data show that the prognosis for patients with metastatic testicular cancer has improved significantly over the past twenty years.

Chronic stress could be one reason why some animal orphans have shorter lives and less offspring. Researchers from the Max Planck Institute for Evolutionary Anthropology in Leipzig and the Institute of Cognitive Sciences, CNRS in Lyon assessed if, as orphan humans, orphan chimpanzees are exposed to chronic stress. They found that maternal loss is stressful but orphans experience little chronic stress since stress hormones return to normal after two years, possibly thanks to care provided by other chimpanzees.

RUDN University doctors found alterations in serum amino acid profile in children with attention deficit hyperactivity disorder (ADHD). The findings will help to understand the mechanism of the disorder and develop new treatment strategies.

International survey by Cluster of Excellence reveals division of European societies into two entrenched camps of substantial size. In Germany, one third hold opposing positions on national belonging, threat, disadvantage. 'Politics should not take one side: positions should be traced back to their respective functional core, compromises sought, polarization stopped.' Most comprehensive survey on identity conflicts in Europe to date.

Peatlands are an important ecosystem that contribute to the regulation of the atmospheric carbon cycle. A multidisciplinary group of researchers, led by the University of Helsinki, investigated the climate response of a permafrost peatland located in Russia during the past 3,000 years. Unexpectedly, the group found that a cool climate period, which resulted in the formation of permafrost in northern peatlands, had a positive, or warming, effect on the climate.

University of Rochester researchers describe the first demonstration of highly chirped pulses created by a using a spectral filter in a Kerr resonator, enabling them to widen a laser pulse wavefront by separating the beam's colors. The chirped pulses remain stable even with more than 90% energy loss.

The extramitochondrial cytochrome C protein may play a protective role in cells subject to low levels of DNA damage, but sentence them to death if the level of damage reaches a tipping point after which repair is impossible.

Nitrogen from agriculture, vehicle emissions and industry is endangering butterflies in Switzerland. The element is deposited in the soil via the air and has an impact on vegetation -- to the detriment of the butterflies, as researchers at the University of Basel have discovered.

Scientists at Friedrich Schiller University in Jena, together with colleagues from Boston University (BU) and Wayne State University (WSU), have now succeeded in preventing dendrite formation and thus at least doubling the lifetime of a lithium metal battery. The researchers report on their method in the renowned journal "Advanced Energy Materials".

A faster method for collecting pure malaria parasites from infected mosquitos could accelerate the development of new, more potent malaria vaccines.

"Boomers" and "millennials" who go to church are more likely to trust their neighbours and donate to charity, according to a new study.

A study by the ICTA-UAB and the University of Porto analyses the effects of exposure to green spaces during the first months of the COVID19 pandemic in Spain and Portugal.

Using neural networks, researchers from the University of Copenhagen have developed a new method to search the human genome for beneficial mutations from Neanderthals and other archaic humans. These humans are known to have interbred with modern humans, but the overall fate of the genetic material inherited from them is still largely unknown. Among others, the researchers found previously unreported mutations involved in core pathways in metabolism, blood-related diseases and immunity.

3D models of bone formation provide a tool for tissue engineering, biomedical research and drug testing.

Recently, a team led by Prof. JIANG Yuqiang from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, collaborating with researchers from the National University of Singapore, University of Electronic Science and Technology of China, and Shanxi University, achieved ultra-fast orbital rotation rate of nanoparticles at subdiffraction scale.