Important advance made with new approach to 'control' cancer, not eliminate it

Important advance made with new approach to 'control' cancer, not eliminate it

PORTLAND, Ore. - Researchers have created a new drug delivery system that could improve the effectiveness of an emerging concept in cancer treatment - to dramatically slow and control tumors on a long-term, sustained basis, not necessarily aiming for their complete elimination.

Israeli lifestyle and environment may pose exceptional risks for Hodgkin's lymphoma

Israeli lifestyle and environment may pose exceptional risks for Hodgkin's lymphoma

Summary: Hodgkin's Lymphoma (HL) is a common malignancy in early adulthood with a complex etiology. In a cohort of 2.3 million Jewish adolescent males and females followed for up to 45 years, being born in Israel was associated with a much elevated risk for nodular sclerosis HL. Higher risks were found among Israeli-born subjects compared to European, Asian and North African immigrants; higher risks were also found for women, those born more recently, those with higher BMI and taller stature.

Feast or famine: The switch that helps your liver adapt

Feast or famine: The switch that helps your liver adapt

Lake Nona, Fla., August 25, 2016 -- Scientists at the Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a previously unknown way that stress hormones (glucocorticoids) shut off genes in the liver to help the body adapt to the fasting state. The study, published today in Cell Metabolism, describes an obscure protein, SETDB2, that's increased during times of fasting and alters the genome to help turn on genes needed to adjust to the absence of food.

US teens more likely to vape for flavorings than nicotine in e-cigarettes

US teens are more likely to vape for the flavourings found in e-cigarettes rather than nicotine, suggests research published online in the journal Tobacco Control.

The findings call into question the designation of e-cigarettes as Electronic Nicotine Delivery Systems (ENDS) and suggest that the recent spike in the popularity of e-cigarettes among this age group doesn't signal a 'nicotine epidemic' as feared, conclude the researchers.

Discovery of a novel Wnt inhibitor with potential to eradicate colorectal cancer stem cells

A team including the National Cancer Center (NCC) (Tokyo, Japan), the RIKEN Center for Life Science Technologies (CLST) (Yokohama, Japan), and Carna Biosciences Inc. (Kobe, Japan) has jointly announced the development of a novel small-molecule Wnt inhibitor named NCB-0846. Wnt signaling is a key pathway of cancer stem cell (CSC) development. The inhibitor may provide a new therapy option for patients with drug-refractory colorectal cancer.

Vouchers help get health goods to those most in need

Distributing health products through a simple voucher system is effective for screening out people who would otherwise accept but not use the free product, a study conducted in Kenya reports. The results inform an ongoing debate about how to get health products to those who need them most without incurring wastage, ultimately suggesting that introducing "small hassles" of time and energy may be more effective than charging money.

The refugee crisis in Europe: Challenges and possible solutions

In this Policy Forum, Randall Hansen and Shalini Randeria discuss the different ideological viewpoints of liberals and conservatives in Europe with respect to accepting refugees, highlighting why - even though the continent is not bearing the "brunt" of the refugee crisis - it remains "in the center of a political and social storm" related to refugees asylum. Globally, there are at least 65 million displaced people, 21 million of whom seek refuge across international borders.

New technique takes guesswork out of IVF embryo selection

Researchers at the University of Adelaide have successfully trialed a new technique that could aid the process of choosing the "best" embryo for implantation, helping to boost the chances of pregnancy success from the very first IVF cycle.

Study shows protein complex essential to creating healthy blood cells

A group of proteins best known for helping to activate all mammalian genes has been found to play a particularly commanding role in the natural development of specialized stem cells into healthy blood cells, a process known as hematopoiesis.

Oxygen can impair cancer immunotherapy in mice

Researchers have identified a mechanism in mice by which anticancer immune responses are inhibited within the lungs, a common site of metastasis for many cancers. This mechanism involves oxygen inhibition of the anticancer activity of T cells. Inhibiting the oxygen-sensing capability of immune cells, either genetically or pharmacologically, prevented lung metastasis.