Body

AUSTIN, Tex -- It's not rare that a baby experiences a stroke around the time it is born. Birth is hard on the brain, as is the change in blood circulation from the mother to the neonate. At least 1 in 4,000 babies are affected shortly before, during, or after birth.

Aurora, Colo. (Feb. 16, 2018) - Researchers at Children's Hospital Colorado (Children's Colorado) have completed the first-ever EXIT (Ex Utero Intrapartum Treatment) to ventricular pacing procedure. The patient, a 36-week fetus, who suffered from complete atrioventricular block (CAVB) and cardiac dysfunction, was at high risk of dying before delivery.

AUSTIN - (Feb. 16, 2018) - Scientists have successfully used gene editing to repair 20 to 40 percent of stem and progenitor cells taken from the peripheral blood of patients with sickle cell disease, according to Rice University bioengineer Gang Bao.

Bao, in collaboration with Baylor College of Medicine, Texas Children's Hospital and Stanford University, is working to find a cure for the hereditary disease. A single DNA mutation causes the body to make sticky, crescent-shaped red blood cells that contain abnormal hemoglobin and can block blood flow in limbs and organs.

Put 50 newborn worms in 50 separate containers, and they'll all start looking for food at roughly the same time. Like members of other species, microscopic C. elegans roundworms tend to act like other individuals their own age.

It turns out that the innate system that controls age-appropriate behavior in a developing worm is not entirely dependable, however. Despite sharing identical genes and growing up in similar environments, some individual worms will inevitably march to the beat of their own drum.

COLUMBUS, OHIO - A clinically relevant "liquid biopsy" test can be used to profile cancer genomes from blood and predict survival outcomes for patients with metastatic triple negative breast cancer (TNBC), according to new research published by a multi-institutional team of researchers with The Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James), the Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard.

Boston, MA (February 16, 2018) - Increasing evidence has linked autism spectrum disorder (ASD) with dysfunction of the brain's cerebellum, but the details have been unclear. In a new study, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex (TSC), a genetic syndrome that often includes ASD-like features. In the lab, the cells showed several characteristics that may help explain how ASD develops at the molecular level.

LA JOLLA, CA--Asthma is a chronic inflammatory disease driven by the interplay of genetics, environmental factors and a diverse cast of immune cells. In their latest study, researchers at La Jolla Institute for Allergy and Immunology (LJI) identified a subset of T cells, whose frequency serves as early childhood immune signature that predicts the risk of developing asthma later on.

Feb. 16, 2018--Women who work as cleaners or regularly use cleaning sprays or other cleaning products at home appear to experience a greater decline in lung function over time than women who do not clean, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

COLUMBUS, Ohio - An international survey of genetic testing labs shows that - despite the availability of BRCA1 and BRCA2 testing for more than two decades - global protocols and standards are surprisingly inconsistent when it comes to analyzing cancer susceptibility genes and their many variations.

Highlights

Three new research articles compare human and mouse kidney development to identify shared and novel features.

The studies provide new detailed molecular data to guide future research.

The studies revealed deep conservation of certain processes, but also significant differences in gene expression during kidney development, as well as in the timing, scale, organization, and molecular profile of key cell types and cell structures.