Body

AUGUSTA, Ga. (Jan. 17, 2018) - Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating or even preventing it.

Sophia Antipolis, 17 January 2018: Nearly a quarter of patients with chronic ischaemic cardiovascular disease are dead or hospitalised within six months, reports a European Society of Cardiology (ESC) study published today in the European Journal of Preventive Cardiology.1

Frequently encountered in the elderly, Alzheimer's is considered a neurodegenerative disease, which means that it is accompanied by a significant, progressive loss of neurons and their nerve endings, or synapses. A joint French and Canadian study published in Scientific Reports now challenges this view.

MADISON - While testing genes to treat glaucoma by reducing pressure inside the eye, University of Wisconsin-Madison scientists stumbled onto a problem: They had trouble getting efficient gene delivery to the cells that act like drains to control fluid pressure in the eye.

Genes can't work until they enter a cell.

DARIEN, IL - January 16, 2018 - Results of a randomized controlled trial suggest that systematic bright light exposure can improve sleep for fatigued people who have been treated for cancer.

Older adults are more likely than younger adults to develop critical illnesses that require hospitalization and intensive care.

DNA is like the computer code of the body, and it must be preserved for our bodies to survive. Yet, as cells grow and change, DNA is vulnerable to defects, especially double strand breaks (DSBs). In fact, DSBs regularly occur throughout one's lifetime. The DNA is protected, however, by DNA repair machinery. A new study from scientists at Osaka University and The University of Tokyo describes the crystal structure of a crucial part of this machinery, the binding of RNF168 to ubiquitylated proteins and find a unique binding not seen in other ubiquitylated protein interactions.

Researchers of the Sarcoma group of the Oncobell program - Bellvitge Biomedical Research Institute (IDIBELL) have successfully tested a new combined therapy for the treatment of this rare, aggressive tumor type, which affects children and adults. The results of the clinical trial, published in Targeted Oncology, represent a successful step in the translational research strategy led by Dr. Òscar Martínez-Tirado, head of the group, on the basic research side, and Dr. Xavier Garcia del Muro, on the clinical side.

A new study that seeks to ascertain HIV mortality rates in Zambia could provide a model for improved national and regional surveillance approaches and, ultimately, more effective HIV treatment strategies.

Experiments with a small group of overweight men and women have added to evidence that "hunger hormone" levels rise and "satiety (or fullness) hormone" levels decrease in the evening. The findings also suggest that stress may increase hunger hormone levels more in the evening, and the impact of hormones on appetite may be greater for people prone to binge eating.