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Lighting the LAMP to reveal mystery of lysosomes
Researchers from Tokyo Medical and Dental University (TMDU) have demonstrated direct homophilic interaction of lysosomal-associated membrane protein 2 (LAMP2). They found that the two-domain architecture of LAMP-2 underlies its proper arrangement and function.
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A direct look at OLED films leads to some pretty exciton findings
University of Tsukuba researchers used time-resolved photoelectron emission microscopy (TR-PEEM) to probe the exciton dynamics of thermally activated delayed fluorescence organic light-emitting diodes (TADF-OLEDs). TADF-OLEDs based on solid-state substrates have significant potential for use in display technology owing to their high efficiency; however, their electron dynamics are not well understood. The TR-PEEM method showed electron accumulation that indicated exciton dissociation. It is hoped that the findings will contribute to advances in OLED displays.
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Small-scale engineering could bring big progress in medical care
Researchers at Arizona State University are using bioengineering to trigger and control cell differentiation and transition is expand possibilities for diagnostics, vaccine development and therapeutic treatments.
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Curtin research finds 'fool's gold' not so foolish after all
Curtin University research has found tiny amounts of gold can be trapped inside pyrite, commonly known as 'fool's gold,' which would make it much more valuable than its name suggests.
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A new concept stent that suppresses adverse effects with cells
Recently, a Korean research team has drawn attention for developing a technology to reduce the adverse effects by accumulating the peripheral substances of cells on the surfaces of the materials. The Korea Institute of Science and Technology (KIST) has released an announcement that the research team of Dr. Yoon Ki Joung, from the Center for Biomaterials, has successfully developed a material that can be used to accumulate substances present at the cell periphery on the surface of implantable medical materials.
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Model of dielectric response promises improved understanding of innovative materials
The contemporary materials industry raises the problem of creating a microscopic theory that allows to describe the observed physicochemical properties of a wide class of substances which are in demand in modern industry, medicine, and agriculture.
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Pushing the boundaries of colloidal quantum dots by making their sizes equal
Perovskite colloidal quantum dots (Pe-CQDs) are highly promising nanocrystals for optoelectronic applications. However, the size of the crystals should ideally be equal to ensure a consistent energy landscape. In a recent study, scientists clarified the relationship between differences in particle size -- polydispersity -- and the optoelectronic characteristics of Pe-CQDs. They showed that using equally sized, or 'monodisperse,' quantum dots results in markedly better performance in Pe-CQD solar cells, paving the way for future optoelectronic devices.
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Making house calls when everyone's staying home: COVID-19 pandemic in Tokyo
Researchers from University of Tsukuba have found that the share of calls to after-hours house call medical services for fever or cold symptoms decreased during the COVID-19 pandemic in Tokyo, but that the severity of symptoms in those patients was significantly increased. Use of such services could reduce the burden on hospitals and early detection could improve patient outcomes if hesitancy to seek treatment in a pandemic can be addressed.
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UC San Diego scientists develop the first CRISPR/Cas9-based gene drive in plants
Researchers have created the first CRISPR-Cas9-based gene drive designed for plants. The new technology, which allows scientists to cut and copy key genetic elements, helps scientists breed plants that defend against crop diseases and withstand the impacts of climate change.
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When pandemic hit, some people wanted more sexual activity
Older men with erectile dysfunction are having more sex than ever before, Pitt study finds.
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AI used to predict unknown links between viruses and mammals
A new University of Liverpool study could help scientists mitigate the future spread of zoonotic and livestock diseases caused by existing viruses.Researchers have used a form or artificial intelligence (AI) called machine-learning to predict more than 20,000 unknown associations between known viruses and susceptible mammalian species. The findings, which are published in Nature Communications, could be used to help target disease surveillance programmes.
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NIST method uses radio signals to image hidden and speeding objects
Researchers at the National Institute of Standards and Technology (NIST) and Wavsens LLC have developed a method for using radio signals to create real-time images and videos of hidden and moving objects, which could help firefighters find escape routes or victims inside buildings filled with fire and smoke. The technique could also help track hypersonic objects such as missiles and space debris.
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COVID-linked multi-system inflammatory syndrome in children diagnosed more in Black and Latino child
Multisystem Inflammatory Syndrome in Children (MIS-C) significantly affected more Black and Latino children than white children, with Black children at the highest risk, according to a new observational study of 124 pediatric patients treated at Children's National Hospital in Washington, D.C. Researchers also found cardiac complications, including systolic myocardial dysfunction and valvular regurgitation, were more common in MIS-C patients who were critically ill.
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Can a calculator predict your risk of dementia?
Researchers have built and validated an online calculator that empowers individuals 55 and over to better understand the health of their brain and how they can reduce their risk of being diagnosed with dementia in the next five years.
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Setting gold and platinum standards where few have gone before
Like two superheroes finally joining forces, Sandia's Z machine -- generator of the world's most powerful electrical pulses -- and Lawrence Livermore's National Ignition Facility -- the planet's most energetic laser source -- have detailed gold and platinum responses to pressures so extreme that their atomic structures momentarily distorted like images in a fun-house mirror.Until now there has been no way to accurately calibrate these pressures , the first step to controlling them.
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Stopping the onset and progression of intractable immune diseases
POSTECH joint research team confirms the suppression and therapeutic effects of specific structural polysaccharide found in yeast for inflammatory diseases in animal models.
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Study shows potential dangers of sweeteners
New research has discovered that common artificial sweeteners can cause previously healthy gut bacteria to become diseased and invade the gut wall, potentially leading to serious health issues. The study, published in the International Journal of Molecular Sciences, is the first to show the pathogenic effects of some of the most widely used artificial sweeteners - saccharin, sucralose, and aspartame - on two types of gut bacteria, E. coli (Escherichia coli) and E. faecalis (Enterococcus faecalis).
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Burnout is a widespread reality in today's NHS
An editorial published by The BMJ today raises important concerns about the health and wellbeing of the NHS workforce after a parliamentary report found "burnout is a widespread reality in today's NHS."
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Kiwi disease study finds closely related bacterial strains display different behaviors
Over the last decade, severe outbreaks of bacterial canker have caused huge economic losses for kiwi growers. Bacterial canker is caused by the bacterial pathogen Pseudomonas syringae pv. actinidiae (Psa) and more recent outbreaks have been particularly devastating due to the emergence of a new, extremely aggressive biovar called Psa3. Due to its recent introduction, the molecular basis of Psa3's virulence is unknown, making it difficult to develop mitigation strategies.
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Early findings of Alzheimer's study in diverse populations now available to researchers
The project is the only comprehensive, large-scale Alzheimer's research study into the three largest ethnic groups in the U.S. - Non-Hispanic whites, Mexican Americans and African Americans.
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