Body

(Lebanon, NH)— Dartmouth scientists showed that more than half of all the SNPs associated with breast cancer risk are located in distant regions and bound by FOXA1, a protein required for estrogen receptor-α (ER) function according to a paper published in the journal Nature Genetics in November.

DURHAM, N.C. -- Rising temperatures and shifting rainfall patterns in Madagascar could fuel the spread of lemur parasites and the diseases they carry.

By combining data on six parasite species from ongoing surveys of lemur health with weather data and other environmental information for Madagascar as a whole, a team of Duke University researchers has created probability maps of likely parasite distributions throughout the island today.

Then, using climate projections for the year 2080, they estimate what parasite distributions might look like in the future.

New research from the University of California, San Diego published in the Jan. 23 issue of Science Translational Medicine moves researchers closer to understanding and developing treatments for shock, sepsis and multiorgan failure. Collectively, these maladies represent a major unmet medical need: they are the number one cause of mortality in intensive care units in the United States, with hundreds of thousands of deaths annually. There is currently no treatment for these conditions in spite of many clinical trials.

Cleveland - A team of researchers led by Goutham Narla, MD, PhD, at Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, and collaborators at the Mount Sinai School of Medicine and Erasmus Medical Center, have discovered a gene variant that drives the spread of breast cancer. Published in Science Translational Medicine (embargoed Jan. 23 at 2:00 pm ET), the study lays the early foundation for predicting which breast cancer patients may develop more aggressive disease and for designing more effective treatments.

In a genome-wide analysis of 13 metastatic prostate cancers, scientists at the Johns Hopkins Kimmel Cancer Center found consistent epigenetic "signatures" across all metastatic tumors in each patient. The discovery of the stable, epigenetic "marks" that sit on the nuclear DNA of cancer cells and alter gene expression, defies a prevailing belief that the marks vary so much within each individual's widespread cancers that they have little or no value as targets for therapy or as biomarkers for treatment response and predicting disease severity.

WASHINGTON (Jan. 23, 2013) – A study led by Robert G. Hawley, Ph.D., professor and chair of the department of anatomy and regenerative biology at the George Washington University (GW) School of Medicine and Health Sciences (SMHS), may help predict which patients with multiple myeloma will respond better to certain treatments.

Alexandria, Va., USA – Today, the International and American Associations for Dental Research (IADR/AADR) published a paper titled "ß-catenin is Required in Odontoblasts for Tooth Root Formation." The paper, written by lead authors Tak-Heun Kim and Cheol-Hyeon Bae, Chonbuk National University Korea School of Dentistry, Laboratory for Craniofacial Biology, is published in the IADR/AADR Journal of Dental Research.

Ice cores drilled in the Greenland ice sheet, recounting the history of the last great warming period more than 120,000 years ago, are giving scientists their clearest insight to a world that was warmer than today.

In the period between 130,000 and 115,000 years ago, Earth's climate was warmer than today. But how much warmer was it and what did the warming do to global sea levels? – as we face global warming in the future, the answer to these questions is becoming very important. New research from the NEEM ice core drilling project in Greenland shows that the period was warmer than previously thought. The international research project is led by researchers from the Niels Bohr Institute and the very important results are published in the prestigious scientific journal, Nature.

Jülich, 23 January 2013 – An international team of researchers has found a new method of producing molecular magnets. Their thin layer systems made of cobalt and an organic material could pave the way for more powerful storage media as well as faster and more energy-efficient processors for information processing. The results of this research have been published in the current issue of the renowned journal Nature (DOI: 10.1038/nature11719).

In Missouri forests, dense thickets of invasive honeysuckle decrease the light available to other plants, hog the attention of pollinators and offer nutrient-stingy berries to migrating birds. They also release toxins that decrease the germination of nearby native plants. Why, then, do studies of invasive species come to different conclusions about their effects and lead some organizations to suggest we accept their presence?

Biologists Kristin Powell, Tiffany Knight and Jon Chase of Washington University in St. Louis have found an answer.

One of the indicators of a cell's health is the state of its DNA and containers—the chromosomes—so when these fuse together or suffer anomalies, they can become the source of illnesses like cancer and/or ageing processes.

URBANA – As the Asian carp population grows and the threat of the invasive species entering Lake Michigan through one of the Chicago canals is monitored, a University of Illinois researcher believes using two barrier methods is better than one.

Cory Suski experimented with adding carbon dioxide (CO2) into the water as a supplemental tool to work in tandem with the electric fence, which has been used to divert the carp from entering the canal, with the goal of providing a second line of defense.

New Rochelle, NY, January 22, 2013—A small compound called an aptamer that specifically targets and stimulates a human immune cell can greatly increase the effectiveness of an immunotherapeutic drug designed to destroy malignant or virus-infected cells. The development of a novel apatamer that recognizes activated T-lymphocytes and can boost the therapeutic effect of cell-based vaccines is described in an article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc.

(CAMBRIDGE, MA) -- Microbiologists who study wild marine microbes, as opposed to the lab-grown variety, face enormous challenges in getting a clear picture of the daily activities of their subjects. But a team of scientists from MIT and the Monterey Bay Aquarium Research Institute recently figured out how to make the equivalent of a nature film, showing the simultaneous activities of many coexisting species in their native habitat over time.