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Scientists have completed the largest and most diverse genetic study of type 1 diabetes ever undertaken, identifying new drug targets to treat a condition that affects 1.3 million American adults.

Several potential drugs are already in the pipeline. Drugs targeting 12 genes identified in the diabetes study have been tested or are being tested in clinical trials for autoimmune diseases. That could accelerate the drugs' repurposing for treating or preventing type 1 diabetes, the researchers say.

Leesburg, VA, July 22, 2021--According to ARRS' American Journal of Roentgenology (AJR), the standardized non-invasive clear cell likelihood score (ccLS)--derived from MRI--correlates with the growth rate of small renal masses (cT1a,

Adults and children with COVID-19 who have a history of malnutrition may have an increased likelihood of death and the need for mechanical ventilation, according to a study published in Scientific Reports.

Malnutrition hampers the proper functioning of the immune system and is known to increase the risk of severe infections for other viruses, but the potential long-term effects of malnutrition on COVID-19 outcomes are less clear.

Participation in elite adult rugby may be associated with changes in brain structure.

This is the finding of a study of 44 elite rugby players, almost half of whom had recently sustained a mild head injury while playing.

The study, part of the Drake Rugby Biomarker Study, was led by Imperial College London and published in the journal Brain Communications.

The research found a significant proportion of the rugby players had signs of abnormalities to the white matter, in addition to abnormal changes in white matter volume over time.

Cambridge, MA ¬- Astronomers at the Center for Astrophysics | Harvard & Smithsonian have helped detect the clear presence of a moon-forming region around an exoplanet -- a planet outside of our Solar System. The new observations, published Thursday in The Astrophysical Journal Letters, may shed light on how moons and planets form in young stellar systems.

If a doctor declares that they are going to another country on vacation to provide free medical care, they get a great deal of social currency from that. Ask a San Francisco doctor to travel to rural California to do the same and you'll be dismissed.

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During yesterday's Golden Globes acceptance speech for best supporting actor, Robert Downey Jr. ("Oppenheimer") seemed to be referencing stage fright when he said "Yeah, yeah, I took a beta-blocker so this will be a breeze." 

Let's ignore that he is pretending he has stage fright, and certainly that accepting an award would give him high blood pressure or heart palpitations, and discuss what we know it really means; celebrities have jumped on the beta blocker fad for social anxiety or depression. Unlike fentanyl or xanax, no one will judge you if you keel over while on beta blockers. No one is worried your propranolol habit is out of hand.

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Presidents Obama and Bush are good friends now, but they wouldn't be in President Bush held a grudge. While campaigning in 2007 and 2008, Senator Obama laid every cultural crime at the feet of the outgoing Republican. And when the housing crisis hit, and he made the economy worse with a stimulus package for government union employees just as President Biden did in 2021, President Obama blamed Bush - even though Bush warned in 2005 that forcing banks to justify why they turned down a mortgage while insuring bad housing loans, at the demand of Democrats, is what led to the housing bubble.

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Even though author JK Rowling controversially believes that being a woman might be more than a state of mind, people bought "Hogwarts Legacy" in droves last year. It was the top-selling game, beating out new entries in the popular "Call of Duty" and "Diablo" franchises.

That is if current trends from November held up. December can be a real confounder because "Call of Duty: Modern Warfare III" came out in November - and quickly rose to the number two spot. It could have beat Harry Potter but we won't know until Activision releases its numbers. Also impressive was "The Legend of Zelda: Tears of the Kingdom", because it was only available on one platform, the Nintendo Switch, while Harry Potter was also available on Xbox, Playstation, and PC.

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A new study describes a new liquid phase in thin films of a glass-forming molecules. These results demonstrate how these glasses and other similar materials can be fabricated to be denser and more stable, providing a framework for developing new applications and devices through better design.

New research has identified potential treatment that could improve the human immune system's ability to search out and destroy cancer cells within the body. Scientists have identified a way to restrict the activity of a group of cells which regulate the immune system, which in turn can unleash other immune cells to attack tumours in cancer patients.

University of Washington scientists have developed a statistical framework that incorporates key COVID-19 data -- such as case counts and deaths due to COVID-19 -- to model the true prevalence of this disease in the United States and individual states. Their approach projects that in the U.S. as many as 60% of COVID-19 cases went undetected as of March 7, 2021, the last date for which the dataset they employed is available.

Mice exposed to the opioid oxycodone before birth experience permanent changes in behavior and gene expression. The new research published in eNeuro highlights a need to develop safer types of painkillers for pregnant women.

Researchers have identified a rare class of genetic differences transmitted from parents without autism to their affected children with autism and determined that they are most prominent in "multiplex" families with more than one family member on the spectrum. These findings are reported in Recent ultra-rare inherited variants implicate new autism candidate risk genes, a new study published in Nature Genetics.

An international team of researchers from the Max Planck Institute for Plant Breeding Research and the University of Åarhus in Denmark have discovered that bacteria from the plant microbiota are adapted to their host species. In a newly published study, they show how root-associated bacteria have a competitive advantage when colonizing their native host, which allows them to invade an already established microbiota.

A new study reports that among individuals who had an allergic reaction to their first mRNA COVID-19 vaccine dose, all who went on to receive a second dose tolerated it. Even some who experienced anaphylaxis following the first dose tolerated the second dose.

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences, Beijing Chaoyang Hospital and the University of Queensland have developed a new formulation based on regulatory T-cell exosomes (rEXS) to deliver vascular endothelial growth factor (VEGF) antibodies for choroidal neovascularization therapy.

Lonely, older adults are nearly twice as likely to use opioids to ease pain and two-and-a-half times more likely to use sedatives and anti-anxiety medications, putting themselves at risk for drug dependency, impaired attention, falls and other accidents, and further cognitive impairment, according to a study by researchers at UC San Francisco.

What The Study Did: Survey data were used to investigate the relationship between loneliness and high-risk medication use in adults older than age 65.

What The Study Did: The association between Medicare eligibility at age 65 and changes in racial and ethnic disparities in access to care and self-reported health was evaluated in this study.