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Mathematicians created a novel mathematical model and found that a mixture of repayment strategies might be best--depending on how much is borrowed and how much income the borrower has.

At least so far, the currently limited research base does not establish that cannabis has additional adverse effects on brain development or functioning in adolescents or young adults with attention-deficit/hyperactivity disorder (ADHD), concludes a review in the July/August issue of Harvard Review of Psychiatry. The journal is published in the Lippincott portfolio by Wolters Kluwer.

In the visual thalamus, neurons are in contact with both eyes but respond to only one

An experimental artificial heart includes an autoregulation control mechanism, or Auto-Mode, that can adjust to the changing needs of patients treated for end-stage heart failure. Outcomes in the first series of patients managed with the new heart replacement pump in Auto-Mode are presented in the ASAIO Journal, official journal of the American Society for Artificial Internal Organs. The journal is published in the Lippincott portfolio by Wolters Kluwer.

A new study paves the way for the development of next generation therapeutics for the prevention and treatment of Clostridioides difficile infection (CDI), the most frequent cause of healthcare-acquired gastrointestinal infections and death in developed countries.

A new study provides insight into what may contribute to men's suicide vulnerability.

Lake Victoria, which came under the spotlight in 2004 by the documentary "Darwin's nightmare", is not only suffering from the introduction and commercialisation of the Nile perch. A study lead researchers from the University of Liège (Belgium) has highlighted other worrying phenomena, particularly climatic ones, which have an equally important impact on the quality of the lake's waters.

Will a reduction in tau protein in brain neurons protect against Parkinson's disease and Lewy body dementias? A new study suggests the answer is no. If this is borne out, that result differs from Alzheimer's disease, where reducing endogenous tau levels in brain neurons is protective for multiple models of the disease -- and thus suggests that the role of tau in the pathogenesis of Lewy body dementias is distinct from Alzheimer's disease.

In a new study, a team of researchers uncovered new mechanisms underlying an important type of resistance to modern prostate cancer drugs called lineage plasticity, where castration-resistant prostate cancers undergo a deadly identity switch. They also outline a promising path to overcoming this form of resistance: BET bromodomain inhibitors.

An international team led by Princeton researchers explored quantum structures called kagome lattices and found insights into the fundamental understanding of quantum order leading to orbital magnetism - that is, magnetism that arises from extended orbital motion of electrons rather than their spin. The findings hint at behaviors that could be precursors of unconventional superconductivity and an anomalous Hall effect.

A science-based intervention relieved hiccups for 92% of 249 users who self-reported the effectiveness of the tool. The study is in JAMA Network Open and is from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) and collaborating investigators.

It could be a milestone on the path to detecting life on other planets: Scientists under the leadership of the University of Bern and of the National Centre of Competence in Research (NCCR) PlanetS detect a key molecular property of all living organisms from a helicopter flying several kilometers above ground. The measurement technology could also open up opportunities for remote sensing of the Earth.

University of Minnesota Medical School researchers determined that the common blood pressure medication, losartan, is not effective in reducing hospitalization for mildly-ill COVID-19 outpatients.

To boost employees' creativity, managers should consider offering a set of rewards for them to choose from, according to a new study by management experts at Rice University, Tulane University, the University of North Carolina at Greensboro and National Taiwan Normal University.

COVID-19: The MAINSTREAM project in Lombardy, Italy -- The true prevalence of COVID-19 is still unknown due to the high proportion of subclinical infection. Measuring seroprevalence may be crucial to improve knowledge about the impact of COVID-19 in rheumatic patients. Data shared at the 2021 EULAR congress highlight that the spread of SARS-CoV-2 infection is much greater than that observed by capturing only swab-diagnosed COVID-19 cases, but consistent with healthy population.

Two recent studies led by researchers from the University of Minnesota Medical School add new evidence to the impact of how drug price increases affect US patients and the overall cost of health care.

Population-based data shared at the EULAR 2021 congress -- The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2) is of particular concern for people with inflammatory diseases, and there are concerns that these people may be at higher risk and have poorer outcomes. However, at present the implications remain poorly understood. Population-based data from Spain show individuals with rheumatoid arthritis (RA) had an increased risk of COVID-19 diagnosis and hospitalization compared to the general population. Similarly, data from the ARTIS database in Sweden show risks of severe COVID-19 were increased among people with inflammatory joint diseases.

UK data shared at the 2021 EULAR congress -- Giant cell arteritis (GCA) is an inflammatory disease that affects the arteries, often causing headaches, jaw pain, and vision problems. The precise cause is not known, but infection is thought to play a role. Immediately following the first wave of the COVID-19 pandemic, the number of GCA diagnoses noticeably increased at the Royal National Hospital for Rheumatic Diseases in Bath, United Kingdom (UK). Furthermore, there was an increase in the proportion of patients with visual complications. The finding is important for understanding the underlying disease mechanisms in GCA, and supports the idea that viral infection could be involved. It also has implications for the provision of local services.

Developing a call to action for a global healthcare challenge -- The current delay to diagnosis from symptom onset represents one of the greatest challenges in axial spondyloarthritis (axSpA) - a type of inflammatory arthritis affecting the back. Research shows an average delay of almost 7 years - and up to 15 years in some cases - during which time the condition can progress and lead to irreversible damage. Data indicates that women wait longer than men for a diagnosis, and there has been very limited progress in reducing the time to diagnosis. This delay has a hugely detrimental impact on a person's quality of life. Because the disease frequently has early onset, individuals are left untreated - or with incorrectly treated symptoms - at a formative period in their life course.

Researchers at William & Mary's Virginia Institute of Marine Science reveal that intensification of major oyster disease was due to evolving parasite, not just drought as previously thought.