Consumers usually look for the lowest price when shopping for a product. But can prices sometimes just feel right? According to a new study in the Journal of Consumer Research, consumers are drawn to prices with rounded numbers when a purchase is motivated by feelings.
"A rounded price ($100.00) encourages consumers to rely on feelings when evaluating products, while a non-rounded price ($98.76) encourages consumers to rely on reason. When a purchase is driven by feelings, rounded prices lead to a subjective experience of feeling right," write authors Monica Wadhwa (INSEAD, Singapore) and Kuangjie Zhang (Nanyang Technological University).
Researchers have revealed that the colonization of the gut of young mice by certain types of bacteria can lead to immune responses later in life that are linked to disease. Increases in the levels of segmented filamentous bacteria can trigger changes in the lymphoid tissue of the mouse gut that result in the production of antibodies that attack components of the cell nucleus. This type of damage is a hallmark of autoimmune diseases like systemic lupus erythematosus and systemic sclerosis where organs throughout the body are damaged by wayward immune responses. The findings are published in The EMBO Journal.
By Andrew Frederick Johnson, University of California, San Diego-->
By Anton Wallner, Australian National University
Our understanding of heavy element production in supernovae, exploding stars way beyond our solar system, may need to change following some discoveries we have made looking not to the skies, but deep under our oceans.
Supernova explosions are one of the most violent events in our galaxy and are thought to produce elements essential for life such as iron and iodine but also some of the heaviest elements existing in nature.
When a star goes supernova and explodes, these heavy elements are thrown out into space as dust and debris.-->
Researchers at the RIKEN-Max Planck Joint Research Center in Japan have demonstrated that hallmark symptoms of Alzheimer's disease can be reduced when sugars are prevented from binding to one of the key enzymes implicated in the disease. The new findings, reported in EMBO Molecular Medicine, show that abnormal attachment of a particular sugar to the enzyme BACE1 is a critical factor leading to the formation of Aβ plaques in the brain, and that plaques were reduced and cognitive performance improved when this action was prevented in mice through loss of the enzyme GnT-III. In doing so, this work has revealed a novel mechanism for Alzheimer's disease development, potentially opening the way to a new approach for treatment.
In the majority of cases, the onset of cancer is characterized by a minor change in a person's genetic material. A cell's DNA mutates in a particular area to the extent that the cell no longer divides in a controlled manner, but begins to grow uncontrollably. In many cases, this type of genetic mutation involves chemical changes to individual building blocks of DNA.
One in five cases of Lassa fever - a disease that kills around 5,000 people a year in West Africa - could be due to human-to-human transmission, with a large proportion of these cases caused by 'super-spreaders', according to a new paper.
Between 2006 and 2012 in the U.S., there was a decline in rates of episiotomy, a surgical procedure for widening the outlet of the birth canal to make it easier for the mother to give birth, according to a study in the January 13 issue of JAMA.
Episiotomy is a common obstetric procedure, estimated to be performed in 25 percent of vaginal deliveries in the United States in 2004. Restrictive use of episiotomy has been recommended given the risks of the procedure and unclear benefits of routine use. Decreasing use of the procedure was documented in the 1990s; however, whether rates have continued to decrease after evidencebased recommendations has not been known, according to background information in the article.
Scientists have gained new insight into fragile X syndrome, the most common cause of inherited intellectual disability, by studying the case of a person without the disorder, but with two of its classic symptoms.
Fragile X syndrome results from an inherited genetic error in a gene called FMR1. The error prevents the manufacture of a protein called FMRP. Loss of FMRP is known to affect how cells in the brain receive signals, dialing up the amount of information allowed in. The gene is on the X chromosome, so the syndrome affects males more often and more severely than females, who may be able to compensate for the genetic error if their second copy of FMR1 is normal.
Every summer, there are reports linking a bacterium called Vibrio vulnificus to people getting sick or dying. The bacteria are found in warm saltwater and problems occur after eating raw tainted shellfish or when an open wound comes in contact with seawater.
People with a weakened immune system, chronic liver disease or iron overload disease are most at risk for severe illness. Vibrio vulnificus infections in high-risk individuals are fatal 50 percent of the time.
Living systems have the ability to produce collective molecular motions that have an effect at the macroscale, such as a muscle that contracts via the concerted action of protein motors. In order to reproduce this phenomenon, a team at CNRS's Institut Charles Sadron led by Nicolas Giuseppone, professor at the Université de Strasbourg, has made a polymer gel that is able to contract through the action of artificial molecular motors. When activated by light, these nanoscale motors twist the polymer chains in the gel, which as a result contracts by several centimeters.
Another advantage is that the new material is able to store the light energy absorbed.
The amount of time children spend using screens, such as televisions and computers, on a daily basis exceeds recommended guidelines but those guidelines were drawn up at a time when tablets, cell phones and other mobile devices were not as present in everyday life. Unless you are Amish or a doomsday prepper, it is unlikely that the future will mean current screen time guidelines.
And how valid are they anyway? Yes, prolonged use of screens by children is associated with adverse physical and mental health outcomes, such as increased risk of depression and anxiety in adolescent girls, but that is epidemiological curve fitting based on surveys, not real data.
New findings from research in the Seychelles provide further evidence that the benefits of fish consumption on prenatal development may offset the risks associated with mercury exposure. In fact, the new study, which appears today in the American Journal of Clinical Nutrition, suggests that the nutrients found in fish have properties that protect the brain from the potential toxic effects of the chemical.
DNA molecules provide the "source code" for life in humans, plants, animals and some microbes. But now researchers report an initial study showing that the strands can also act as a glue to hold together 3-D-printed materials that could someday be used to grow tissues and organs in the lab. This first-of-its-kind demonstration of the inexpensive process is described in the brand-new journal ACS Biomaterials Science & Engineering.
A variety of wheat that is resistant to a destructive fungal disease has been found to have specialized and protective cell walls, according to research published in BMC Plant Biology. These insights could help to produce stronger, disease-resistant varieties of durum wheat for improved pasta production.