A toxic chemical produced by tiny marine microbes worked against laboratory models of colon cancer, notes a study in ACS Medicinal Chemistry Letters, in which medicinal chemists describe how they took a generally lethal byproduct of marine cyanobacteria, Apratoxin S4, and made it more specifically toxic — to cancer cells.
When the scientists gave low doses of the compound to mice with a form of colon cancer, they found that it inhibited tumor growth without the overall poisonous effect of the natural product. Even at relatively high doses, the agent was effective and safe.