Brain

Euthymics Bioscience, Inc. today will present Phase II clinical data demonstrating that its lead product candidate EB-1010, a next-generation antidepressant, is effective for treating major depressive disorder (MDD) based on multiple standard measures of outcome for depression. EB-1010 also improved measures of anhedonia, a hallmark symptom of MDD, which is characterized by the inability to experience pleasure. The data further demonstrate that EB-1010 is well tolerated, without the weight gain or sexual dysfunction associated with the most common pharmacological treatments for depression.

Chevy Chase, MD—A recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM) has demonstrated a novel and accurate test for early diagnosis of Turner syndrome. Turner syndrome affects one in 1,500 to 2,000 female live births and early diagnosis allows for the timely management of short stature and co-morbid conditions including cardiac and renal problems.

DURHAM, N.C. – The brain's visual neurons continually develop predictions of what they will perceive and then correct erroneous assumptions as they take in additional external information, according to new research done at Duke University.

This new mechanism for visual cognition challenges the currently held model of sight and could change the way neuroscientists study the brain.

Flying insects' altitude control mechanisms are the focus of research being conducted in a Caltech laboratory under an Air Force Office of Scientific Research grant that may lead to technology that controls altitude in a variety of aircraft for the Air Force.

A school-based intervention program designed for adolescents with asthma significantly improves asthma management and quality of life for the students who participate, and reduces asthma morbidity, according to researchers in New York City, who studied the effect of the program aimed at urban youth and their medical providers. The Asthma Self-Management for Adolescents (ASMA) program is an eight-week intervention geared toward helping adolescents learn more effective ways of managing their symptoms and controlling their asthma.

Scientists have created a way to isolate neural stem cells – cells that give rise to all the cell types of the brain – from human brain tissue with unprecedented precision, an important step toward developing new treatments for conditions of the nervous system, like Parkinson's and Huntington's diseases and spinal cord injury.

The work by a team of neuroscientists at the University of Rochester Medical Center was published in the Nov. 3 issue of the Journal of Neuroscience. Neurologist Steven Goldman, M.D., Ph.D., chair of the Department of Neurology, led the team.

Investigators at Southern Methodist University and The University of Texas at Dallas have discovered a family of small molecules that shows promise in protecting brain cells against nerve-degenerative diseases such as Parkinson's, Alzheimer's and Huntington's, which afflict millions.

Questionnaire results and DNA samples volunteered by a group of University of Alberta students has broken new ground in the study of aggression. U of A Psychology researcher Peter Hurd was looking at the link between an individual's sensitivity to testosterone and aggressive behaviour.

"I looked at the gene that makes the body's testosterone detector to determine if variations in this detector's sensitivity to the chemical causes people to be more or less aggressive," said Hurd.

MAYWOOD, Ill. -- A new technique that jumpstarts the growth of nerve fibers could reverse much of the damage caused by strokes, researchers report in the Jan. 7, 2011 issue of the journal Stroke.

"This therapy may be used to restore function even when it's given long after ischemic brain damage has occurred," senior author Gwendolyn Kartje, MD, PhD and colleagues write.

MAYWOOD, Ill. -- Surgery to remove tumors under the brain known as acoustic neuromas produces favorable outcomes in the "vast majority" of patients, according to one of the largest studies of its kind.

Loyola University Hospital surgeons Dr. Douglas Anderson and Dr. John Leonetti followed 730 patients whom they had jointly operated on during a 21-year period. Patients ranged in age from 9 to 79, with a median age of 48. The average clinical followup was 32 months.

7 December 2010 – We commonly think of sleep as a healing process that melts away the stresses of the day, preparing us to deal with new challenges. Research has also shown that sleep plays a crucial role in the development of memories.

An important component of anxiety disorders, including posttraumatic stress disorder (PTSD), is the formulation of memories associated with fear.

When an antibiotic is consumed, researchers have learned that up to 90 percent passes through a body without metabolizing. This means the drugs can leave the body almost intact through normal bodily functions.

Brussels, 7 December 2010 – Polar research must become an integral part of the European Union's research activities if Europe is to benefit from the dramatically changing face of the Polar Regions, the European Polar Board (EPB) said today at the launch of its strategic position paper on European polar research: "Relevance, Strategic Context and Setting Future Directions."

Television's favourite Time Lord could not exist without his trusty sonic screwdriver, as it's proved priceless in defeating Daleks and keeping the Tardis in check. Now Doctor Who's famous cure-all gadget could become a reality for DIY-ers across the world, say engineers.

Ultrasonic engineers at Bristol University and The Big Bang: UK Young Scientists and Engineers Fair are uncovering how a real life version of the fictional screwdriver - which uses sonic technology to open locks and undo screws - could be created.