Our brains are packed with cholesterol, almost all of which has to be produced within the brain itself, where it is critical for normal brain functions. Now, a new study in the December Cell Metabolism, a Cell Press publication, reveals how that critical cholesterol synthesis in the brain is derailed in mice with diabetes.
The findings offer a new explanation for the neurologic and cerebral complications that come with diabetes, including cognitive dysfunction, depression, and an increased risk of Alzheimer's disease, according to the researchers.