Brain

The virus responsible for PML (progressive multifocal leukoencephalopathy), a rare brain disease that typically affects AIDS patients and other individuals with compromised immune systems, has been found to be reactivated in multiple-sclerosis patients being treated with natalizumab (Tysabri). The findings, led by scientists at Beth Israel Deaconess Medical Center (BIDMC), appear in The New England Journal of Medicine (NEJM).

Alexis Webb, a graduate student at Washington University in St. Louis in the neuroscience program, worked with Erik Herzog, Ph.D., associate professor of biology in Arts & Sciences; Nikhil Angelo, an undergraduate biology major; and James Huettner, Ph.D., associate professor of cell biology and physiology in the School of Medicine, to demonstrate that individual cells isolated from the biological clock can keep daily time all by themselves.

However, by themselves, they are unreliable. The neurons get out of sync and capriciously quit or start oscillating again.

New research with mice has provided some fascinating insight into how addictive drugs hijack reward signals and influence neural processes associated with learning and memory. The research, published by Cell Press in the September 10th issue of the journal Neuron, helps to explain why and how drug-associated memories, such as the place of drug use, drive and perpetuate the addiction.

HOUSTON – (Sept. 9, 2009) – Ever wonder why former smokers miss lighting up most when they are in a bar or after a meal with friends?

Researchers at Baylor College of Medicine say nicotine, the addictive component in cigarettes, "tricks" the brain into creating memory associations between environmental cues and smoking behavior. The findings appear in the current issue of the journal Neuron.

A study led by MassGeneral Hospital for Children (MGHfC) investigators is providing new insight into the mechanism of neonatal seizures, which have features very different from seizures in older children and adults.

Scientists may have discovered a way to glean information about stored memories by tracking patterns of eye movements, even when an individual is unable (or perhaps even unwilling) to report what they remember. The research, published by Cell Press in the September 10th issue of the journal Neuron, provides compelling insight into the relationship between activity in the hippocampus, eye movements, and both conscious and unconscious memory.

Irvine, Calif. – A woman looks familiar, but you can't remember her name or where you met her. New research by UC Irvine neuroscientists suggests the memory exists – you simply can't retrieve it.

Using advanced brain imaging techniques, the scientists discovered that a person's brain activity while remembering an event is very similar to when it was first experienced, even if specifics can't be recalled.

CHICAGO --- People with mental illnesses such as depression and anxiety are the heaviest smokers in the country, but their doctors are afraid to ask them to quit. They assume that if their patients try to quit smoking, their mental disorders will get worse.

That is a myth, according to Brian Hitsman, a tobacco addiction specialist and assistant professor of preventive medicine at Northwestern University Feinberg School of Medicine. He also is a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

A recent study by Jasmohan Bajaj, M.D., and colleagues from Virginia Commonwealth University and McGuire VA Medical Center found that patients with cirrhosis of the liver who developed minimal hepatic encephalopathy (MHE) had a 16% rate of motor vehicle crashes compared to only 4% of those without MHE over one year. The rate of accidents was also significantly higher than the state annual crash rate of 3%-3.3%.

In an advance toward better treatments for the most serious form of brain cancer, scientists in Illinois are reporting development of the first nanoparticles that seek out and destroy brain cancer cells without damaging nearby healthy cells. The study is scheduled for the Sept. 9 issue of ACS' Nano Letters, a monthly journal.

Identifying a face can be difficult when that face is shown for only a fraction of a second. However, young adults have a marked advantage over elderly people in these conditions. Researchers writing in the open access journal BMC Neuroscience found indications that elderly people have reduced perception speed.

Shame is a common reaction when someone feels that they have fallen below social norms or their own standards. From being intoxicated in front of one's peers and superiors to failing an important test at school or being rejected at the school dance, shame can be an internal alarm that ensures that we know when we are at risk of finding ourselves outside the lines of societal acceptance and desirability.

A brain-imaging study conducted at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory provides the first definitive evidence that patients suffering from attention deficit hyperactivity disorder (ADHD) have lower-than-normal levels of certain proteins essential for experiencing reward and motivation.

Scientists led a rat to the fatty food, but they couldn't make it eat. Using an animal model of binge eating, University of Missouri researchers discovered that deactivating the basolateral amygdala, a brain region involved in regulating emotion, specifically blocked consumption of a fatty diet. Surprisingly, it had no effect on the rat wanting to look for the food repeatedly.

TORONTO, ON – Students will have to use their brains to get good grades at school this year, according to new University of Toronto research that relates brain activity to undergraduate academic performance.

In the first study ever to link academic performance to a neural signal, participants performed a Stroop task – a well-known test of cognitive control – while hooked up to EEG electrodes that measured their brain activity.