Body

ACE inhibitors, commonly used to control high blood pressure and heart failure in women, may be associated with an increased risk of recurrence in women who have had breast cancer, according to a study by researchers at UCLA's Jonsson Comprehensive Cancer Center.

Research from Perth's Telethon Institute for Child Health Research has found a link between the number of stressful events experienced during pregnancy and increased risk of behavioural problems in children.

The study has just been published online in the latest edition of the top international journal Development and Psychopathology.

Common stressful events included financial and relationship problems, difficult pregnancy, job loss and issues with other children and major life stressors were events such as a death in the family.

Local extinction rates of American pikas have increased nearly five-fold in the last 10 years, and the rate at which the climate-sensitive species is moving up mountain slopes has increased 11-fold, since the 20th century, according to a study soon to be published in Global Change Biology. The research strongly suggests that the American pika's distribution throughout the Great Basin is changing at an increasingly rapid rate.

The first research to actively analyze adult male sea turtles (Caretta caretta) using satellite tracking to link geography with pollutants has revealed the potential risks posed to this threatened species by manmade chemicals. The research, published today in Environmental Toxicology and Chemistry, examines the different levels of chemicals in the blood of both migratory and residential turtles.

Patients admitted to hospital with inflammatory bowel disease (IBD) face a sixfold greater risk of death if they become infected with Clostridium difficile, a new study has found. The researchers say IBD patients should be screened on admission to protect them from serious illness.

IBD, consisting of Crohn's disease and ulcerative colitis, affects around 240,000 people in the UK and its symptoms include abdominal pain and diarrhoea. When sufferers experience a bout of severe symptoms, they often need to be admitted to hospital.

Experts today challenge the view that popular drugs to prevent disease - like statins and antihypertensives to prevent heart disease and stroke, or bisphosphonates to prevent fractures – represent value for money.

In a paper published on bmj.com today, Teppo Järvinen and colleagues argue that the benefits seen when these drugs are tested in clinical trials may not apply in the real world.

In this week's PLoS Medicine, Stephan Harbarth from the University of Geneva, Switzerland and colleagues argue that the International Health Regulations (IHR) should be applied to the global health threat of antimicrobial resistance. They say that certain events marking the emergence and spread of antimicrobial-resistant bacteria, especially those involving new pan-resistant strains for which there are no suitable treatments, may constitute a Public Health Emergency of International Concern (PHEIC) and are notifiable to WHO under the IHR notification requirement.

HUNTSVILLE, Ala - The international team of the ENCODE, or Encyclopedia Of DNA Elements project, has created an overview of its ongoing large-scale efforts to interpret the human genome sequence.

A massive database cataloging the human genome's functional elements -- including genes, RNA transcripts, and other products -- is being made available as an open resource to the scientific community, classrooms, science writers, and the public, thanks to an international team of researchers.

An analysis of data from Medicare beneficiaries who underwent hip replacement or subsequent follow-up corrective surgery between 1991 and 2008 indicates that the length of hospital stay after surgery declined during this time period, as did the proportion of patients discharged home, while there was an increase in the rate of hospital readmissions and discharge to a skilled care facility, according to a study in the April 20 issue of JAMA.

Cancer survival rates could improve soon with whole-genome sequencing, according to two studies published in the April 20, 2011, issue of the Journal of the American Medical Association that describe the first clinical applications of the high-tech process in patients with cancer.

Two new studies highlight the power of sequencing cancer patients' genomes as a diagnostic tool, helping doctors decide the best course of treatment and researchers identify new cancer susceptibility mutations that can be passed from parent to child.

Both studies, by researchers at Washington University School of Medicine in St. Louis, are reported April 20 in the Journal of the American Medical Association.

An Ohio State biophysicist used a supercomputer to search thousands of molecular combinations for the best configuration to block a protein that can cause breast or prostate cancer.

NJIT Associate Professor Sergiu M. Gorun is leading a research team to develop biologically-inspired catalysis active, yet inert, materials. The work is based on organic catalytic framework made sturdy by the replacement of carbon-hydrogen bonds with a combination of aromatic and aliphatic carbon-fluorine bonds. Graduate students involved with this research recently received first place recognition at the annual NJIT Dana Knox student research showcase. http://www.njit.edu/news/2011/2011-101.php

Researchers at The Wistar Institute have found a new way to force cancer cells to self-destruct. Low doses of one anti-cancer drug currently in development, called Gamitrinib, sensitize tumor cells to a second drug, called TRAIL, also currently in clinical development as part of an anticancer regimen.