Body

STANFORD, Calif. — A class of engineered nanoparticles — gold-centered spheres smaller than viruses — has been shown safe when administered by two alternative routes in a mouse study led by investigators at the Stanford University School of Medicine. This marks the first step up the ladder of toxicology studies that, within a year and a half, could yield to human trials of the tiny agents for detection of colorectal and possibly other cancers.

Researchers at Rice University and Texas A&M have discovered a way to pattern active proteins into bio-friendly fibers. The "eureka" moment came about because somebody forgot to clean up the lab one night.

The new work from the Rice lab of biochemist Kathleen Matthews, in collaboration with former Rice faculty fellow and current Texas A&M assistant professor Sarah Bondos, simplifies the process of making materials with fully functional proteins. Such materials could find extensive use as chemical catalysts and biosensors and in tissue engineering, for starters.

"The three gut types can explain why the uptake of medicines and nutrients varies from person to person," says bioinformatician Jeroen Raes of the VIB and Vrije Universiteit Brussel, one of the two lead researchers in the study. "This knowledge could form the basis of personalized therapies. Treatments and doses could be determined on the basis of the gut type of the patient."

Improved knowledge of the gut types could also lead to other medical applications, such as the early diagnosis of intestinal cancer, Crohn's disease and the adverse effects of obesity.

Scientists at Imperial College London and the University of Washington, Seattle, have taken an important step towards developing control measures for mosquitoes that transmit malaria. In today's study, published in Nature, researchers have demonstrated how some genetic changes can be introduced into large laboratory mosquito populations over the span of a few generations by just a small number of modified mosquitoes.

In the future, when you walk into a doctor's surgery or hospital, you could be asked not just about your allergies and blood group, but also about your gut type. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and collaborators in the international MetaHIT consortium, have found that humans have 3 different gut types. The study, published today in Nature, also uncovers microbial genetic markers that are related to traits like age, gender and body-mass index.

Thanks to a certain protein, rhesus monkeys are resistant to HIV. Known as TRIM5, the protein prevents the HI virus from multiplying once it has entered the cell. Researchers from the universities of Geneva and Zurich have now discovered the protein's mechanism, as they report in Nature. This also opens up new prospects for fighting HIV in humans.

BUFFALO, NY -- Exposure to air pollution early in life and when a woman gives birth to her first child may alter her DNA and may be associated with premenopausal breast cancer later in life, researchers at the University at Buffalo have shown.

The findings indicated that higher air pollution exposure at birth may alter DNA methylation, which may increase levels of E-cadherin, a protein important to the adhesion of cells, a function that plays an essential role in maintaining a stable cellular environment and assuring healthy tissues.

PHILADELPHIA - Researchers at the University of Pennsylvania School of Medicine are delving into the details of the complex structure at the ends of chromosomes. Recent work, e-published in Nature Structural & Molecular Biology last month, describes how these structures, called telomeres, can be protected by caps made up of specialized proteins and stacks of DNA called G-quadruplexes, or "G4 DNA." Telomere caps are like a knot at the end of each chromosome "string," with the knot's role preventing the string from unraveling.

ALEPPO, SYRIA (20 April 2011): Researchers meeting at a scientific conference in Aleppo this week reported that aggressive new strains of wheat rust diseases – called stem rust and stripe rust – have decimated up to 40% of farmers' wheat fields in recent harvests. Areas affected are North Africa, the Middle East, Central Asia and the Caucuses, including Syria, Egypt, Yemen, Turkey, Iran, Uzbekistan, Morocco, Ethiopia, and Kenya.

New York, NY, April 20, 2011 - A 20-member blue-ribbon panel, the Study Group on Corporate Boards, co-sponsored by Columbia Business School and the John L. Weinberg Center for Corporate Governance at the University of Delaware, today released "Bridging Board Gaps," a report designed to improve board performance and effectiveness by offering a series of recommendations in critical areas of governance.

The costly, often-frustrating quest for new ways of preventing and treating diseases that strike vegetables, fruits, and other food crops bears striking similarity to the better-known saga of the pharmaceutical industry's pricey search for new drugs for humans. That's the topic of an article in the current edition of Chemical & Engineering News (C&EN), ACS' weekly newsmagazine.

DURHAM, N.C. – A major discovery about an enzyme's structure has opened a window on understanding DNA repair. Scientists at Duke University Medical Center have determined the structure of a nuclease that will help scientists to understand several DNA repair pathways, a welcome development for cancer research.

DNA repair pathways are very important in the context of cancer biology and aging, but the tools the cell uses to do those repairs are not well understood.

FAIRFAX, Va.—The Society of Interventional Radiology has a long-term commitment to radiation safety, taking a leading role in measuring and assessing radiation dosage; developing educational programs on radiation safety, radiation protection and reduction of skin dosage; and promoting the safety of patients and health care professionals.

Researchers of Apoptosis and Cancer Group of the Bellvitge Biomedical Research Institute (IDIBELL) have found that a small molecule, Nutlin-3a, an antagonist of MDM2 protein, stimulates the signalling pathway of another protein, p53. By this way, it induces cell death and senescence (loss of proliferative capacity) in brain cancer, a fact that slows its growth. These results open the door for MDM2 agonists as new treatments for glioblastomas. The study has been published at the journal PLoS ONE.

In a multicellular organism, different cells fulfill a range of diversified functions. Often such specialization depends on the delivery of molecular goods to distinct places within a cell. It ensures that particular functions only occur at defined cellular sites. This establishment of intracellular asymmetry in the otherwise fluid environment of the cell cytoplasm requires active transport processes. Messenger RNAs (mRNA) represent an especially important type of freight. They are copies of genetic information stored in the nucleus.