Body

MADISON -- A diagnosis of multiple sclerosis (MS) is a hard lot. Patients typically get the diagnosis around age 30 after experiencing a series of neurological problems such as blurry vision, wobbly gait or a numb foot. From there, this neurodegenerative disease follows an unforgiving course.

Many people with MS start using some kind of mobility aid -- cane, walker, scooter or wheelchair -- by 45 or 50, and those with the most severe cases are typically bed-bound by 60. The medications that are currently available don't do much to slow the relentless march of the disease.

BOSTON—Scanning the DNA of nearly 5,000 tumor samples, a team led by scientists at Dana-Farber Cancer Institute and the Broad Institute has identified 140 regions of scrambled genetic code believed to contain many undiscovered cancer genes.

WASHINGTON, Sept. 26, 2013 – In a first-of-its-kind study to evaluate the impact of a medical specialty on patient outcomes, researchers found that hospitalized patients with severe infections such as meningitis and Clostridium difficile (C. diff.) are significantly less likely to die if they receive care from an infectious diseases specialist. The study, which analyzed nearly 130,000 Medicare patient cases, is now available online and will be published in the December 15 issue of Clinical Infectious Diseases.

Coffee is one of the most extensively researched components in the diet. New studies are regularly being added to the already large body of scientific research, which overall suggests that moderate habitual coffee consumption is not associated with detrimental effects on cardiovascular health

The receptor used by baculovirus to enter and interact with human cells has been identified. This syndecan-1 receptor was identified for the first time in a recent collaborative study carried out by the University of Eastern Finland and the University of Jyväskylä in Finland. The findings increase our understanding of the strategies by which the virus causes infection in cells and further facilitates the development of baculovirus for applications of gene transfer.

The c-Fos oncogene has traditionally been linked to cellular activities related to cancer, such as cell division, differentiation—conversion from one cell type to another—or survival. Any alteration of these activities can set off the development of tumours, which has made c-Fos an important target for the understanding and treatment of cancer.

Every year, millions of cattle die of trypanosomosis. The UN and the International Livestock Research Institute list trypanosomosis among the ten diseases of cattle with the greatest impact on the poor. In Africa the disease is known as "Nagana", which translates literally as "being in low or depressed spirits". The disease is caused by a parasite that enters the animals' blood as a result of the bite of the Tsetse fly.

A Case Western Reserve University professor wondered why some types of research were more apt to secure federal grants, while others -- especially exploratory science -- often didn't.

Using the National Institutes of Health (NIH) as a case study, Assistant Philosophy Professor Chris Haufe concluded that hypothesis-based research has the edge over discovery research for several reasons that he explains in a new paper.

After doing specific training for 12 weeks, people over the age of 90 improved their strength, power and muscle mass. This was reflected in an increase in their walking speed, a greater capacity to get out of their chairs, an improvement in their balance, a significant reduction in the incidence of falls and a significant improvement in muscle power and mass in the lower limbs.

A joint BYU-Utah research team is developing a new breast cancer screening technique that has the potential to reduce false positives, and, possibly, minimize the need for invasive biopsies.

Led by BYU electrical engineer Neal Bangerter and University of Utah collaborators Rock Hadley and Joshua Kaggie, the group has created an MRI device that could improve both the process and accuracy of breast cancer screening by scanning for sodium levels in the breast.

EAST BOOTHBAY, ME – Although long thought to be devoid of life, the bottom of the deep ocean is now known to harbor entire ecosystems teeming with microbes. Scientists have recently documented that oxygen is disappearing from seawater circulating through deep oceanic crust, a significant first step in understanding the way life in the "deep biosphere" beneath the sea floor is able to survive and thrive. The new research findings were published in the journal Nature Communications on September 27, 2013, and are helping to redefine our concepts of the limits of life on our planet.

PHILADELPHIA — A bioinformatics approach to repurposing drugs resulted in identification of a class of antidepressants as a potential new treatment for small-cell lung cancer (SCLC), according to a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

STANFORD, Calif. — A little-used class of antidepressants appears potentially effective in combating a particularly deadly form of lung cancer, according to a new study from researchers at the Stanford University School of Medicine.

Benzathine penicillin G (BPG) is the most essential antibiotic for the treatment and prevention of group A streptococcal infections associated with rheumatic fever and rheumatic heart disease. Yet while some countries such as South Africa and Brazil have stable supplies, most countries with a high RHD burden often suffer interruptions in supply and also have quality control issues. The problems around supply of this drug are discussed in one of the papers of the RHD special issue of Global Heart, the journal of the World Heart Federation.

As this year's World Heart Day approaches (Sunday September 29), focus is returning to a neglected and entirely preventable heart disease that largely affects the world's youngest and poorest populations: rheumatic heart disease (RHD). To highlight this long-neglected condition, Global Heart, the journal of The World Heart Federation (WHF) is publishing a special issue dedicated to RHD.