Body

Scientists of the International Multiple Sclerosis Genetics Consortium (IMSGC) have identified an additional 48 genetic variants influencing the risk of developing multiple sclerosis. This work nearly doubles the number of known genetic risk factors and thereby provides additional key insights into the biology of this debilitating neurological condition.

New results from a trial of an antibody that helps the immune system to recognise and attack cancer cells have shown particularly encouraging responses in patients who are smokers or former smokers.

Identifying the molecular profile of a tumour where the primary site is unknown is crucial to the choice of treatment, the 2013 European Cancer Congress (ECC2013) [1], will hear on Monday. In up to five percent of all cancers, the site of the primary tumour is unknown and the disease is not diagnosed until it is at an advanced stage, when the cancer has metastasised (spread to other parts of the body).

What keeps leukemia cells alive almost forever, able to continue dividing endlessly and aggressively? New research at the Weizmann Institute suggests that, in around a quarter of all leukemias, the cancer cells rely on an internal "balance of terror" to keep going. When one version of a certain gene is mutated, it becomes a cancer-promoting gene – an oncogene. But the new findings show that the second, normal version of the gene, which functions alongside the mutation, is what keeps the cells both cancerous and alive, able to continue forging their destructive pathway in the body.

Bethesda, MD -- It's not the little blue pill famous for helping men get big results, but for those who need it, the outcome might be even more significant. A new research report published online in The FASEB Journal, offers hope to men who experience priapism. This condition, which is often seen in men with sickle cell disease, causes erections lasting so long that they cause permanent damage to the penis.

A programme funded by the Bill & Melinda Gates Foundation may have saved around 600,000 people in India from becoming infected with HIV over the course of a decade, according to a new report.

Avahan, the India AIDS Initiative, which was launched in 2003, aimed to prevent HIV transmission in the general population through a comprehensive HIV prevention programme including the promotion of condoms among the people at most risk – female sex workers, high risk men who have sex with men and intravenous drug users – in the six Indian states with the highest HIV rates.

SALT LAKE CITY, Sept. 29, 2013 – One problem in developing more efficient organic LED light bulbs and displays for TVs and phones is that much of the light is polarized in one direction and thus trapped within the light-emitting diode, or LED. University of Utah physicists believe they have solved the problem by creating a new organic molecule that is shaped like rotelle – wagon-wheel pasta – rather than spaghetti.

HOUSTON -- (Sep. 29, 2013) – As so many genome studies do, this study published online in the journal Nature Genetics began with a single patient and his parents who were in search of a diagnosis.

PROVIDENCE, R.I. [Brown University] — A research team centered at Brown University has compiled the largest and most stringently validated list of RNA editing sites in the fruit fly Drosophila melanogaster, a stalwart of biological research. Their research, which yielded several insights into the model organism's fundamental biology, appears Sept. 29 in Nature Structural & Molecular Biology.

LA JOLLA, CA – September 29, 2013 – Highlighting an important but unexplored area of evolution, scientists at The Scripps Research Institute (TSRI) have found evidence that, over hundreds of millions of years, an essential protein has evolved chiefly by changing how it moves, rather than by changing its basic molecular structure.

The work has implications not only for the understanding of protein evolution, but also for the design of antibiotics and other drugs that target the protein in question.

AMSTERDAM -- For many years, patients with advanced thyroid cancer faced bleak prospects and no viable treatment options. But now, building on recent discoveries about the genetics and cell signaling pathways of thyroid tumors, researchers are developing exciting new weapons against the disease, using kinase inhibitors that target tumor cell division and blood vessels. Two recent clinical trials led by a researcher from the Perelman School of Medicine at the University of Pennsylvania showcase the great promise of these new approaches.

Understanding the impact of environmental change on plant traits is an important issue in evolutionary biology. As the only direct evidence of past life, fossils provide important information on the interactions between plants and environmental change. After ten years' survey, Professor Zhou Zhekun's group from Kunming Institute of Botany has discovered more than ten well preserved Neogene plant fossil sites in southwestern China which are important to understand past climate and response of plants to the changing climate in this region.

Combining traditional forms of Chinese and Western medicine could offer new hope for developing new treatments for liver, lung, colorectal cancers and osteosarcoma of the bones.

Experts from Cardiff University's School of Medicine have joined forces with Peking University in China to test the health benefits of a traditional Chinese medicine.

The team also set-out to examine how by combining it with more traditional methods like Chemotherapy could improve patient outcomes and potentially lead to the development of new cancer treatments and therapies.

Amsterdam, The Netherlands: First results from a phase III clinical trial of the combination drug, T-DM1, show that it significantly improves the length of time before the disease worsens in women with advanced HER2 positive breast cancer whose cancer has recurred or progressed despite previous treatments, including trastuzumab and lapatinib.

Giving radiation therapy to the lymph nodes located behind the breast bone and above the collar bone to patients with early breast cancer improves overall survival without increasing side effects. This new finding ends the uncertainty about whether the beneficial effect of radiation therapy in such patients was simply the result of irradiation of the breast area, or whether it treated cancer cells in the local lymph nodes as well, the 2013 European Cancer Congress (ECC2013) [1] will hear today (Saturday).