Body

The United States Preventive Services Task Force (USPSTF) found insufficient evidence to recommend for or against routine screening for primary hypertension in asymptomatic children and adolescents. Hypertension in children and adolescents has increased over the past several decades, which may be attributable to the climb in childhood overweight and obesity rates. An estimated 11 percent of obese children in the United States suffer from hypertension, putting them at increased risk for hypertension in adulthood.

Maternal psychological distress combined with exposure to air pollution during pregnancy have an adverse impact on the child's behavioral development, according to researchers at the Columbia Center for Children's Environmental Health at the Mailman School of Public Health.

There are an estimated 100,000 Histoplasma infections each year in the United States. Most are contained by the body's immune system, but each year a few thousand people will develop chronic or life-threatening histoplasmosis disease requiring hospitalization and antifungal treatment. The antifungals currently used to treat the infection have undesirable toxic side effects requiring monitoring by a physician and may need to be taken for weeks or months.

Since 1996, corn containing a gene that allows it to create a protein that is toxic to certain insects, yet safe for human consumption, has been grown in the United States. However, most of this "Bt corn" has been used for animal feed or processed into corn meal, starch, or other products. Although varieties of sweet corn (corn on the cob) have existed since the late 1990s, relatively few acres have been planted.

A unique study of 16 pairs of identical twins in which one twin is obese and the other lean has yielded some surprising results. In 8 of the pairs of twins, the obese twin was as 'metabolically healthy' as his or her lean co-twin, while in the other 8 pairs, the obese twin had a poorer blood fat profile, higher liver fat and increased insulin production and resistance, and higher blood pressure -- all hallmarks of unhealthy obesity that can lead to diabetes, heart problems and other complications.

MAYWOOD, Il. – Physicians have long observed that binge drinking can significantly impair the healing process following a bone fracture.

Now a study by Loyola University Medical Center researchers is providing insights into how alcohol slows healing on the cellular and molecular levels. The findings could lead to treatments to improve bone healing in alcohol abusers, and possibly non-drinkers as well.

ANN ARBOR, Mich. — A global hunt for genes that influence heart disease risk has uncovered 157 changes in human DNA that alter the levels of cholesterol and other blood fats – a discovery that could lead to new medications.

Each of the changes points to genes that can modify levels of cholesterol and other blood fats and are potential drug targets. Many of the changes point to genes not previously linked to blood fats, also called lipids. A surprising number of the variations were also associated with coronary artery disease, type 2 diabetes, obesity, and high blood pressure.

Biologists of the University of Zurich have developed a method to visualize the activity of genes in single cells. The method is so efficient that, for the first time, a thousand genes can be studied in parallel in ten thousand single human cells. Applications lie in fields of basic research and medical diagnostics. The new method shows that the activity of genes, and the spatial organization of the resulting transcript molecules, strongly vary between single cells.

MANHASSET, NY – Investigators at The Feinstein Institute for Medical Research have discovered a protein in the human body that can trigger and mediate inflammation in patients suffering from hemorrhage and sepsis. The findings were published in the online version of Nature Medicine on October 6, 2013.

OKLAHOMA CITY, Oct. 6, 2013 — With the completion of the first genome-wide association study for Sjögren's syndrome, an international coalition of researchers led by scientists at the Oklahoma Medical Research Foundation has identified six new disease-related genes.

Their work appears in the journal Nature Genetics.

DETROIT – A skin infection linked to exposure to contaminated water in home aquariums is frequently under-diagnosed, according to a Henry Ford Hospital study.

Researchers say diagnosing and managing Mycobacterium marinum infection is difficult because skin lesions don't appear for two to four weeks after incubation, leading to delayed treatment and unnecessary and ineffective use of antifungal and antibacterial agents.

CINCINNATI—University of Cincinnati (UC) researchers have discovered a biomarker, known as phosphatidylserine (PS), for pancreatic cancer that could be effectively targeted, creating a potential therapy for a condition that has a small survival rate.

Philadelphia, Pa. (October 4, 2013) – Doctors who abuse prescription drugs often do so for "self-medication"—whether for physical or emotional pain or stress relief, reports a study in the October Journal of Addiction Medicine, the official journal of the American Society of Addiction Medicine.

University of Notre Dame researchers Shahriar Mobashery and Mayland Chang and their collaborators in Spain have published research results this week that show how methicillin-resistant Staphylococcus aureus (MRSA) regulates the critical crosslinking of its cell wall in the face of beta-lactam antibiotics.

INDIANAPOLIS -- An Indiana University cancer researcher and his colleagues have discovered new therapeutic targets and drugs that may someday benefit people with certain types of leukemia or blood cancer.