Body

The genome is full of sequence repetitions. Sequence motif is added after sequence motif, sometimes more than a hundred times. Erratically it seems. And these sequence motifs bind proteins that control transcription factors in regions of the genome where no transcription should occur. A conundrum.

Liver transplantation is the mainstay of treatment for patients with end-stage liver disease, the 12th leading cause of death in the United States, but new research from the Icahn School of Medicine at Mount Sinai, published in the online journal Cell Stem Cell today, suggests that it may one day become possible to regenerate a liver using cell therapy in patients with liver disease.

Scientists at the Danish Stem Cell Center, DanStem, at the University of Copenhagen have discovered that they can make embryonic stem cells regress to a stage of development where they are able to make placenta cells as well as the other fetal cells. This significant discovery, published in the journal Cell Reports today, has the potential to shed new light on placenta related disorders that can lead to problematic pregnancies and miscarriages.

ROSEMONT, Ill.—Supplemental child restraints should be used by all children through age 8. When appropriate child safety restraint systems—based on a child's age and weight—are in use during motor vehicle crashes, the rates of mortality and serious injury significantly decrease. Most parents don't know that their older children—ages 4 to 8—should use additional measures to protect them from serious injury or death in case of a crash.

New Rochelle, NY, June 6, 2013— Immunocompromised mice, created by inactivating the genes that would allow them to recognize and attack donor cells or organs, are critical for studies of bone marrow reconstitution. A more rapid and reliable technique for identifying these mice in breeding colonies is described in an article in BioResearch Open Access.

Researchers from Germany have found that low levels of vitamin D are associated with high levels of hepatitis B virus (HBV) replication. Findings published online in Hepatology, a journal of the American Association for the Study of Liver Diseases, suggest seasonal fluctuations in vitamin D and HBV levels point to a link in these variables among patients with chronic HBV.

A team of researchers has made a significant discovery which may have a dramatic impact on children stricken with Tay-Sachs disease, a degenerative and fatal neurological condition that often strikes in the early months of life.

Available drugs may dramatically ease a child's suffering, say scientists.

Since ancient times, the pressures of excessive hunting have contributed to the gradual decline of wildlife populations and even the extinction of certain species in many areas.

Researchers from the Polytechnic University of Madrid (UPM) and the Centre for Forestry Research (INIA-CIFOR) have studied the developments in big game in Spain between 1972 and 2007 to gain an understanding of the hunting trends of the last decades.

University of Adelaide researchers have developed a simple and cost-effective DNA test to identify kangaroo species from their droppings which will boost the ability to manage and conserve kangaroo populations.

The researchers developed the test using hundreds of collected droppings across north-eastern Australia and extracting DNA from the samples, published in the conservation journal Wildlife Research.

The drug ingenol mebutate (trade name: Picato) has been approved in Germany since November 2012 as a gel for the treatment of certain forms of actinic keratosis in adults. In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG) the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether this new drug offers an added benefit over diclofenac/hyaluronic acid gel.

ANN ARBOR—Efforts to restore sturgeon in the Great Lakes region have received a lot of attention in recent years, and many of the news stories note that the prehistoric-looking fish are "living fossils" virtually unchanged for millions of years.

But a new study by University of Michigan researchers and their colleagues reveals that in at least one measure of evolutionary change—changes in body size over time—sturgeon have been one of the fastest-evolving fish on the planet.

Patients battling cancer have a better experience of care at hospitals that employ more cancer specialist nurses.

Research from the University of Southampton, shows that patients of better staffed hospitals are more likely to report being given more emotional support by nurses who work well together on wards.

How and when evolution generates diversity or gives form to proteins, living beings' functional building blocks, are essential questions that still surround the theory of evolution. In humans, the majority of genes have emerged via genetic duplication, a strategy in which a gene generates two identical copies that can evolve to generate different proteins.

Cincinnati, OH, June 6, 2013 -- Sports-related concussion has been referred to as an "epidemic" by the Centers for Disease Control and Prevention. Emergency department visits for concussions have increased 62% between 2001 and 2009. Despite the lack of data regarding the rates of concussions in youth football (children aged 8-12 years), concerns have been raised about the sport being dangerous for this age group.

Philadelphia, PA, June 6, 2013 – By analyzing biopsy specimens from patients with postmenopausal osteoporosis and primary hyperparathyroidism, investigators have begun to pay increasing attention to "reversal cells," which prepare for bone formation during bone remodeling. The hope is that these reversal cells will become critical therapeutic targets that may someday prevent osteoporosis and other bone disorders. This study is published in the July 2013 issue of The American Journal of Pathology.