New Rochelle, NY, June 6, 2013— Immunocompromised mice, created by inactivating the genes that would allow them to recognize and attack donor cells or organs, are critical for studies of bone marrow reconstitution. A more rapid and reliable technique for identifying these mice in breeding colonies is described in an article in BioResearch Open Access.
Alejandro Ferrer, Adam Schrum, and Diana Gil, College of Medicine, Mayo Clinic (Rochester, MN), designed a simple method for identifying mice with specific gene deletions or replacements, using a DNA amplification technique called polymerase chain reaction, or PCR.
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