Body

DETROIT – Henry Ford Hospital researchers have identified for the first time two molecules that hold promise as a biomarker for measuring cartilage damage associated with osteoarthritis.

Researchers say the concentration of two molecules called non-coding RNAs in blood were associated with mild cartilage damage in 30 patients who were one year removed from reconstruction surgery to repair an anterior cruciate ligament, or ACL, injury.

Lost in the euphoria of the 2003 announcement that the human genome had been sequenced was a fundamental question: how can we be sure that an individual's genome has been read correctly?

While the first full, individual genome was sequenced a decade ago, given the vast genetic variation across the world's seven billion people, not to mention the differences in makeup even among close relatives, the question of accurate sequencing for individuals has continued to vex researchers.

Sequencing a patient's entire genome to discover the source of his or her disease is not routine – yet. But geneticists are getting close.

A case report, published this week in the American Journal of Human Genetics, shows how researchers can combine a simple blood test with an "executive summary" scan of the genome to diagnose a type of severe metabolic disease.

La Jolla, CA---- One of the big mysteries in biology is why cells age. Now scientists at the Salk Institute for Biological Studies report that they have discovered a weakness in a component of brain cells that may explain how the aging process occurs in the brain.

The scientists discovered that certain proteins, called extremely long-lived proteins (ELLPs), which are found on the surface of the nucleus of neurons, have a remarkably long lifespan.

SAN DIEGO -- Tocagen Inc. today announced the publication of data showing the company's investigational treatment for high grade glioma eradicates brain tumors and provides a dramatic survival benefit in mouse models of glioblastoma. Almost all mice receiving the top dose of Toca 511 followed by 5-FC were still alive at 180 days, which was the termination date for the experiment, whereas all control mice died by day 43. The article was published today in the February issue of the Neuro-Oncology journal.

Ottawa, Ontario –Could the use of vitamin and mineral supplements in a regular diet help to reduce the risk of colon cancer and protect against carcinogens? A study published in the Canadian Journal of Physiology and Pharmacology (CJPP) found that rats given regular multivitamin and mineral supplements showed a significantly lower risk of developing colon cancer when they were exposed to carcinogens.

People who suffer a traumatic experience often don't talk about it, and many forget it over time. But not talking about something doesn't always mean you'll forget it; if you try to force yourself not to think about white bears, soon you'll be imagining polar bears doing the polka. A group of psychological scientists explore the relationship between silence and memories in a new paper published in Perspectives on Psychological Science, a journal of the Association for Psychological Science.

Jim Black is fighting the meanest, most aggressive, most common kind of brain tumor in the United States: recurrent glioblastoma multiforme (GBM). In the United States, each year, approximately 10,000 patients are affected by GBM. Now, a novel investigational device – available only at clinical trial sites – is offering new hope to these patients.

New Rochelle, NY -- If the proven long-term benefits of smoking cessation are not enough to motivate young adults to stop smoking, a new study shows that 18- to 24-year olds who stop smoking for at least two weeks report substantially fewer respiratory symptoms, especially coughing. The study findings are detailed in Pediatric Allergy, Immunology, and Pulmonology, a peer-reviewed journal published by Mary Ann Liebert, Inc. The article is available online.

Refugee children have scant access to medical care and are particularly vulnerable to disease. Fresh research results from the University of Copenhagen show that just a few hours of schooling a week may have a pronounced positive impact on their health not only in childhood but later in life when they achieve adulthood.

The U.S. may have its first black president and the Fortune 500 its first black female chief executive, but African American CEOs account for a mere one percent of the chiefs of those 500 largest companies.

Andrew Carton, assistant professor of management and organization at Penn State Smeal College of Business, and Ashleigh Shelby Rosette of Duke University, suggest in the current issue of the Academy of Management Journal that what steers people's perceptions of African Americans are stereotypes about blacks' leadership failings, biases that may not even be conscious.

Biologists who released lizards on tiny uninhabited islands in the Bahamas have uncovered a seldom-observed interaction between evolutionary processes.

Jason Kolbe, a biologist at the University of Rhode Island (URI)--along with colleagues at Duke University, Harvard University and the University of California, Davis--found that the lizards' genetic and morphological (form and structural) traits were determined by both natural selection and a phenomenon called the founder effect.

Their research results are published online today in the journal Science.

PHILADELPHIA -- Soy isoflavone supplements did not decrease breast cancer cell proliferation in a randomized clinical trial, according to a study published in Cancer Prevention Research, a journal of the American Association for Cancer Research.

Lead researcher Seema A. Khan, M.D., professor of surgery at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, said the results of this study are consistent with the findings of previous studies that were designed to test cancer prevention benefits of dietary supplements.

A team of Spanish researchers have used different geological samples, extracted from the Enol lake in Asturias, to show that the Holocene, a period that started 11,600 years ago, did not have a climate as stable as was believed.

The Holocene period, which includes the last 11,600 years of our history, has always been described as a stable period in terms of climatic conditions, especially when compared to the abrupt changes that occurred in the last ice age, which ended around 10,000 years ago, giving way to the Holocene.

If you wanted to draw your family tree, you could start by searching for people who share your surname. Cells, of course, don't have surnames, but scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have found that genetic switches called enhancers, and the molecules that activate those switches – transcription factors – can be used in a similar way, as clues to a cell's developmental history. The study, published today in Cell, also unveils a new model for how enhancers function.