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HIV-infected youth, psychiatric symptoms and functional outcomes

CHICAGO – A study of children and adolescents who had been infected perinatally (around the time of their birth) with human immunodeficiency virus (HIV) suggests little evidence of an association between specific antiretroviral therapy and the severity of psychiatric disorders, according to a report published Online First by Archives of Pediatrics & Adolescent Medicine, one of the JAMA/Archives journals.

Domestic cats, and wild bobcats and pumas, living in same area have same diseases

Domestic cats, wild bobcats and pumas that live in the same area share the same diseases.

And domestic cats may bring them into human homes, according to results of a study of what happens when big and small cats cross paths.

Initial results of the multi-year study are published today in the scientific journal PLoS One by a group of 14 authors.

Metabolic 'breathalyzer' reveals early signs of disease

MADISON – The future of disease diagnosis may lie in a "breathalyzer"-like technology currently under development at the University of Wisconsin-Madison.

New research published online in February in the peer-reviewed journal Metabolism demonstrates a simple but sensitive method that can distinguish normal and disease-state glucose metabolism by a quick assay of blood or exhaled air.

Big jolt to state economy with new tax on cigarettes

A new UCSF analysis has found that a state ballot initiative to increase the cigarette tax would create about 12,000 jobs and nearly $2 billion in new economic activity in California.

The study found that the new tax would have a significant effect on the state's overall economy because Californians would smoke less and spend their money in other ways.

Spectator rage: The dark side of professional sports

CHESTNUT HILL, MA -- Preventing violent outbreaks of "spectator rage", similar to the deadly riots that broke out following a soccer game in Egypt, requires assessment and action by sports team owners and stadium managers, according to a report in the forthcoming issue of the Journal of Service Research.

Why bad immunity genes survive

SALT LAKE CITY, Feb. 6, 2012 – University of Utah biologists found new evidence why mice, people and other vertebrate animals carry thousands of varieties of genes to make immune-system proteins named MHCs – even though some of those genes make us susceptible to infections and to autoimmune diseases.

Individual differences in anthrax susceptibility discovered by Stanford scientists

STANFORD, Calif. — Susceptibility to anthrax toxin is a heritable genetic trait that may vary tremendously among individuals, according to a new study by researchers at the Stanford University School of Medicine.

Among 234 people studied, the cells of three people were virtually insensitive to the toxin, while the cells of some people were hundreds of times more sensitive than those of others. The findings may have important implications for national security, as people known to be more resistant to anthrax exposure could be effective first-line responders in times of crises.

Tasting fructose with the pancreas

ORLANDO, Fla., February 6, 2012 – Taste receptors on the tongue help us distinguish between safe food and food that's spoiled or toxic. But taste receptors are now being found in other organs, too. In a study published online the week of February 6 by the Proceedings of the National Academy of Sciences of the USA, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) discovered that beta cells in the pancreas use taste receptors to sense fructose, a type of sugar.

Fossil cricket reveals Jurassic love song

Some 165 million years ago, the world was host to a diversity of sounds. Primitive bushcrickets and croaking amphibians were among the first animals to produce loud sounds by stridulation (rubbing certain body parts together). Modern-day bushcrickets – also known as katydids – produce mating calls by rubbing a row of teeth on one wing against a plectrum on the other wing but how their primitive ancestors produced sound and what their songs actually sounded like was unknown – until now.

LSUHSC research identifies new prostate cancer drug target

New Orleans, LA – Research led by Wanguo Liu, PhD, Associate Professor of Genetics at LSU Health Sciences Center New Orleans, has identified a new protein critical to the development and growth of prostate cancer. The findings are published online in the Early Edition of Proceedings of the National Academy of Sciences, available the week of February 6, 2012.

MassGeneral, Jackson researchers find clues to common birth defect in gene expression data

Researchers at MassGeneral Hospital for Children (MGHfC), The Jackson Laboratory and other institutes have uncovered 27 new candidate genes for congenital diaphragmatic hernia (CDH), a common and often deadly birth defect.

Their sophisticated data-filtering strategy, which uses gene expression during normal development as a starting point, offers a new, efficient and potentially game-changing approach to gene discovery.

A bug's (sex) life: Diving beetles offer unexpected clues about sexual selection

Studying female reproductive tracts and sperm in diving beetles (Dytiscidae), researchers from the University of Arizona and Syracuse University have obtained a glimpse into a bizarre and amazing world of sperm that can take on a variety of forms – including joining together into conglomerates that navigate the twisted mazes of the female reproductive tract.

Analyses of the evolutionary relationships among diving beetles reveal that sperm form appears to follow function dictated by female reproductive organs.

Whole-genome sequencing of 2011 E. coli outbreaks in Europe provides new insight

Boston, MA — Using whole-genome sequencing, a team led by researchers from Harvard School of Public Health (HSPH) and the Broad Institute has traced the path of the E. coli outbreak that sickened thousands and killed over 50 people in Germany in summer 2011 and also caused a smaller outbreak in France. It is one of the first uses of genome sequencing to study the dynamics of a food-borne outbreak and provides further evidence that genomic tools can be used to investigate future outbreaks and provide greater insight into the emergence and spread of infectious diseases.

NYU Langone orthopaedic experts present research, clinical advances at AAOS meeting

Experts from the Department of Orthopaedic Surgery at NYU Langone Medical Center will present their latest research and clinical findings on diseases of the muscle, tendon, bone and joint at the annual meeting of the American Academy of Orthopaedic Surgeons (AAOS), February 7-11 in San Francisco, California.

Smallest tools could give biggest results in bone repair

MADISON – When William Murphy works with some of the most powerful tools in biology, he thinks about making tools that can fit together. These constructions sound a bit like socket wrenches, which can be assembled to turn a half-inch nut in tight quarters, or to loosen a rusted-tight one-inch bolt using a very persuasive lever.