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PHILADELPHIA –The pneumococcal vaccine recommended for young children not only prevents illness and death, but also has dramatically reduced severe antibiotic-resistant infections, suggests nationwide research being presented at IDWeek 2014™. Pneumococcal infection – which can cause everything from ear infections to pneumonia and meningitis – is the most common vaccine-preventable bacterial cause of death.

Large numbers of fish will disappear from the tropics by 2050, finds a new University of Britsh Columbia study that examined the impact of climate change on fish stocks. The study identified ocean hotspots for local fish extinction but also found that changing temperatures will drive more fish into the Arctic and Antarctic waters.

The initial benefits of an outpatient antimicrobial stewardship intervention designed to reduce the rate of inappropriate antibiotic prescriptions were lost after discontinuation of audit and feedback to clinicians, according to a study published in JAMA. The study is being released early online to coincide with the IDWeek 2014 meeting.

Using a recently developed biomarker of aging known as an epigenetic clock, UCLA researchers working closely with a German team of investigators have found for the first time that obesity greatly accelerates aging of the liver. This finding could explain the early onset of many age-related diseases, including liver cancer, in obese subjects

Proteins regulating cell division determine tumour growth. Ongoing clinical trials are currently studying inhibitors for two of these proteins, Cdk4 and Cdk6, targeting several types of cancer, such as breast cancer, lung cancer and leukaemia. The Cell Division and Cancer Group at the Spanish National Cancer Research Centre (CNIO), led by Marcos Malumbres, has discovered the molecular mechanism behind the interaction of these proteins. Researchers also demonstrated in mice that the simultaneous inhibition of both molecules is more effective than the individual inhibition.

The so-called Signal Transducers and Activators of Transcription, or STATs, are key components of many different signalling pathways. Not surprisingly, then, when something goes wrong with their regulation the consequences can be severe and many types of cancer are known to be associated with increased activities of one or more STAT protein. STAT3 is a frequent culprit and is often found to be activated in tumour cells.

A novel technique which reduces image degradation caused by respiratory motion during a PET scan was developed in a recent study at the University of Eastern Finland. PET scanning is routinely used to detect cancer and heart conditions. The new technique presented in the PhD thesis of Tuomas Koivumäki, MSc (Tech.), is based on bioimpedance measurement and it allows for image reconstruction at a specific phase of the patient's breathing pattern. This, in turn, makes it possible to reduce image degradation caused by motion.

New Orleans, LA – A special study using data from LSU Health New Orleans School of Public Health's Louisiana Tumor Registry has found that colorectal cancer incidence rates in the Louisiana Acadian parishes are among the highest in the United States. This study appears to be the first to identify a high rate of cancer in a large, regional, US founder population, raising the possibility of a genetic predisposition. Alternatively, an unidentified, robust environmental risk factor may be present.

WASHINGTON, DC – OCTOBER 10, 2014 - Mineral coatings on sand particles actually encourage microbial activity in the rapid sand filters that are used to treat groundwater for drinking, according to a paper published ahead of print in Applied and Environmental Microbiology. These findings resoundingly refute, for the first time, the conventional wisdom that the mineral deposits interfere with microbial colonization of the sand particles.

A study on the global burden of venous thromboembolism—when a dangerous clot forms in a blood vessel—found that annual incidences range from 0.75 to 2.69 per 1,000 individuals in the population. The incidence increased to between 2 and 7 per 1,000 among those 70 years of age or more.

A new study led by a Canadian marine zoologist reviews the world list of specialist driftwood talitrids, which so far comprises a total of 7 representatives, including two newly described species. These tiny animals with peculiar habits all live in and feed on decomposing marine driftwood. Dispersed across distant oceanic islands they use floating driftwood to hitch a ride to their destination. The study was published in the open access journal Zoosystematics and Evolution.

Ann Arbor, Mich. — A web-based system that allows preschools and child care centers to report illnesses to local public health departments could improve the detection of disease outbreaks and allow resources to be mobilized more quickly, according to University of Michigan research to be presented Saturday, Oct. 11 at the American Academy of Pediatrics (AAP) National Conference & Exhibition in San Diego.

DURHAM, N.C. –- No single "one-size-fits-all" model can explain how biodiversity hotspots come to be, finds a study of more than 700 species of reptiles and amphibians on the African island of Madagascar.

By analyzing the geographic distribution of Madagascar's lizards, snakes, frogs and tortoises, an international team of researchers has found that each group responded differently to environmental fluctuations on the island over time.

The Centers for Disease Control and Prevention has said that at least 2 million Americans are sickened by antibiotic resistant infections each year and survive. (Twenty-three thousand die.) These experiences leave deep impressions not just on the patients but on their family and friends.

(PHILADELPHIA) – Some cancers, like breast and prostate cancer, are driven by hormones such as estrogen and testosterone, but to date, there are none that are driven by the lack of a hormone. New evidence suggests that human colon cells may become cancerous when they lose the ability to produce a hormone that helps the cells maintain normal biology. If verified by further studies, it suggests that treating patients at high risk for colon cancer by replacing the hormone guanylin could prevent the development of cancer.