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In elk hunting, success depends on the animal's personality

(Edmonton) University of Alberta led research shows an elk's personality type is a big factor in whether or not it survives the hunting season.

Data collected from GPS collars on more than 100 male and female elk in southwestern Alberta showed U of A researchers the study population could be divided into two categories: bold runners and shy hiders:

Increased mortality in HIV-positive South African men versus women is unrelated to HIV/AIDS

In South Africa, HIV-infected men who are receiving treatment with anti-HIV drugs (antiretroviral therapy) are almost a third more likely to die than HIV-positive women who are receiving similar treatment: however, these differences are likely to be due to gender differences in death rates in the general population rather than related to HIV, according to a study by a team of international researchers published in this week's PLOS Medicine.

Southeast Asian ovalocytosis protects against P. vivax malaria

A multinational group of authors, led by Ivo Mueller from the Walter & Eliza Hall Institute, Australia and the Papua New Guinea Institute of Medical Research, have found a strong association between Southeast Asian ovalocytosis, an inherited disorder that affects the shape of red blood cells, and protection against malaria caused by Plasmodium vivax. The investigators genotyped 1975 children enrolled in three independent epidemiological studies conducted in the Madang area of Papua New Guinea for this common hemoglobin gene mutation, and assessed P.

'Benign' malaria key driver of human evolution in Asia-Pacific

Their finding challenges the widely-accepted theory that Plasmodium falciparum, which causes the most lethal form of malaria, is the only malaria parasite capable of driving genome evolution in humans. The study was published today in the journal PLOS Medicine.

Professor Ivo Mueller from the Walter and Eliza Hall Institute and Barcelona Centre for International Health Research (CRESIB) led the study, with colleagues from the Papua New Guinea Institute of Medical Research, Centre of Global Health and Diseases, US, and the University of Western Australia.

Rare genetic disease offers insight into common cancers

Fanconi anemia is a recessive genetic disorder affecting 1 in 350,000 babies, which leaves cells unable to repair damaged DNA. This lack of repair puts Fanconi anemia patients at high risk for developing a variety of cancers, especially leukemias and head and neck cancer. Cruelly, the condition also nixes the use of an entire class of cancer drugs, namely drugs like mitomycin C that act by encouraging DNA to crosslink together like sticky strands of bread dough – generally, healthy cells can repair a few crosslinks whereas cancer cells cannot and so are killed.

Scripps Florida scientists design molecule that reverses some fragile X syndrome defects

JUPITER, FL - Scientists on the Florida campus of The Scripps Research Institute have designed a compound that shows promise as a potential therapy for one of the diseases closely linked to fragile X syndrome, a genetic condition that causes mental retardation, infertility, and memory impairment, and is the only known single-gene cause of autism.

Vitamin D supplement fails to lower cholesterol in short term

Taking vitamin D supplements to compensate for vitamin D deficiency didn't improve cholesterol — at least in the short term, according to new research in Arteriosclerosis, Thrombosis and Vascular Biology, an American Heart Association journal.

Researchers studied 151 people with vitamin D deficiency who received either a mega-dose (50,000 internationals units) of vitamin D3 or placebo weekly for eight weeks. Participants' cholesterol levels were measured before and after treatment.

Study points to new target for cancers resistant to Iressa and Herceptin

A more-sensitive method to analyze protein interactions has uncovered a new way that cancer cells may use the cell-surface molecule HER3 to drive tumor progression following treatment with HER1 and HER2 inhibitors.

Stiffening of aortic wall linked with increased risk of high blood pressure

CHICAGO – An analysis of the relationship between several vascular function measures and blood pressure levels finds that certain measures including higher aortic stiffness were associated with a higher risk of new hypertension; however, initial blood pressure was not independently associated with risk of progressive aortic stiffening, suggesting that vascular stiffness may be a precursor rather than the result of hypertension, according to a study in the September 5 issue of JAMA.

Cardiac study evaluates prevalence of unrecognized heart attacks among older adults

CHICAGO – Using cardiac magnetic resonance imaging among older adults in Iceland, researchers estimated the prevalence of unrecognized heart attacks, which was associated with an increased risk of death, according to a study in the September 5 issue of JAMA.

Biologic therapy for rheumatoid arthritis not significantly linked with increased malignancy risk

CHICAGO – Although there are concerns regarding the potential development of malignancies in patients with rheumatoid arthritis who are receiving treatment with biologic response modifiers (BRMs), pooled results from more than 60 randomized controlled trials did not find a statistically significant increased risk of any type of cancer with use of BRMs for at least 6 months compared with traditional disease-modifying antirheumatic drugs or with placebo, according to the results of a meta-analysis published in the September 5 issue of JAMA.

Vitamin D supplements do not improve cholesterol as previous research suggested

Vitamin D has been touted for its beneficial effects on a range of human systems, from enhancing bone health to reducing the risk of developing certain cancers. But it does not improve cholesterol levels, according to a new study conducted at The Rockefeller University Hospital. A team of scientists has shown that, at least in the short term, cholesterol levels did not improve when volunteers with vitamin D deficiency received mega-doses of vitamin D. The finding is published in the journal Arteriosclerosis, Thrombosis and Vascular Biology.

Study finds biologic therapies for rheumatoid arthritis not associated with increased cancer risk

HOUSTON – Biologic therapies developed in the last decade for rheumatoid arthritis are not associated with an increased risk of cancer when compared with traditional treatments for the condition, according to new research from The University of Texas MD Anderson Cancer Center.

Showing the way to improved water-splitting catalysts

PASADENA, Calif.—Scientists and engineers around the world are working to find a way to power the planet using solar-powered fuel cells. Such green systems would split water during daylight hours, generating hydrogen (H2) that could then be stored and used later to produce water and electricity. But robust catalysts are needed to drive the water-splitting reaction. Platinum catalysts are quite good at this, but platinum is too rare and expensive to scale up for use worldwide.

Human impact felt on Black Sea long before industrial era

When WHOI geologist Liviu Giosan first reconstructed the history of how the Danube River built its delta, he was presented with a puzzle.

In the delta's early stages of development, the river deposited its sediment within a protected bay. As the delta expanded onto the Black Sea shelf in the late Holocene and was exposed to greater waves and currents, rather than seeing the decline in sediment storage that he expected, Giosan found the opposite. The delta continued to grow. In fact, it has tripled its storage rate.