Body

"So there is an interesting conundrum," Morgan says. "What are these myelin-associated genes doing in an animal that doesn't have myelin, and yet is good at regeneration? It opens up a new and interesting set of questions, " she says. Addressing them could bring insight to why humans lost the capacity for neural regeneration long ago, and how this might be restored.

Diabetic patients are more than twice as likely to die from a heart attack as non-diabetic patients, but the mechanisms that underlie increased heart attack-related mortality in diabetic patients are unknown.

High levels of the oxidized form of the protein CamKII (ox-CaMKII) have been linked to increased risk of sudden death after heart attack. Additionally, hearts from diabetic patients have significantly greater ox-CAMKII compared to hearts from non-diabetic patients.

DETROIT – Research conducted at Henry Ford Hospital shows that race and possibly genetics play a role in children's sensitivity to developing allergies.Researchers found:

CHAPEL HILL, N.C. - Head and neck squamous cell carcinoma (HNSCC) is the seventh most common form of cancer in the United States, but other than an association with the human papillomavirus, no validated molecular profile of the disease has been established. By analyzing data from DNA microarrays, a UNC-led team has completed a study that confirms the presence of four molecular classes of the disease and extends previous results by suggesting that there may be an underlying connection between the molecular classes and observed genomic events, some of which affect known cancer genes.

A protein known for turning on genes to help cells survive low-oxygen conditions also slows down the copying of new DNA strands, thus shutting down the growth of new cells, Johns Hopkins researchers report. Their discovery has wide-ranging implications, they say, given the importance of this copying — known as DNA replication — and new cell growth to many of the body's functions and in such diseases as cancer.

Washington University engineering researchers have created a new type of air-cleaning technology that could better protect human lungs from allergens, airborne viruses and ultrafine particles in the air.

The device, known as the SXC ESP, was created by a team led by Pratim Biswas, PhD, the Lucy & Stanley Lopata Professor and chair of the Department of Energy, Environmental & Chemical Engineering in the School of Engineering & Applied Science.

PHILADELPHIA – For years researchers have been searching for a way to treat diabetics by reactivating their insulin-producing beta cells, with limited success. The "reprogramming" of related alpha cells into beta cells may one day offer a novel and complementary approach for treating type 2 diabetes. Treating human and mouse cells with compounds that modify cell nuclear material called chromatin induced the expression of beta cell genes in alpha cells, according to a new study that appears online in the Journal of Clinical Investigation.

Studies by the U.S. Department of Agriculture (USDA) are shedding some light on the microbes that dwell in cattle manure—what they are, where they thrive, where they struggle, and where they can end up.

The research conducted by Agricultural Research Service (ARS) scientists at the agency's Agroecosystems Management Research Unit in Lincoln, Neb., supports the USDA priority of ensuring food safety. ARS is USDA's chief intramural scientific research agency.

Newswise — Sometimes the best discoveries come by accident.

A team of researchers at Washington University in St. Louis, headed by Srikanth Singamaneni, PhD, assistant professor of mechanical engineering & materials science, unexpectedly found the mechanism by which tiny single molecules spontaneously grow into centimeter-long microtubes by leaving a dish for a different experiment in the refrigerator.

Pulmonary fibrosis is a scarring or thickening of the lungs that causes shortness of breath, a dry cough, fatigue, chest discomfort, weight loss, a decrease in the ability of the lungs to transmit oxygen to the blood stream, and, eventually, heart failure. Cells known as myofibroblasts normally secrete materials that are required for wound healing; once the wound has closed, the cells disappear. In pulmonary fibrosis, the myofibroblasts stick around, continuing to secrete wound healing factors that cause fibrosis in the lungs.

Epigenetic modification is a change to gene expression or cellular phenotype that is caused by alterations that don't involve the underlying DNA sequence. Because all cells in your body contain the exact same genes, these epigenetic changes help determine which genes different cells express, allowing them to develop specialized functions.

Parthenogenesis is a form of asexual reproduction during which unfertilized eggs begin to develop as if they had been fertilized. It occurs naturally in many plants and a few invertebrate (some bees, scorpions, parasitic wasps) and vertebrate animals (some fish, reptiles, and amphibians), but does not occur naturally in mammals. In 2007, researchers were able to chemically induce human egg cells to undergo parthenogenesis. The resulting parthenogenote has properties similar to an embryo, but cannot develop further.

Los Angeles, CA (February 22, 2013) Studies report that since 2004, suicides rates in the U.S. Army have been on the rise. While researchers debate the cause, a new study finds that among suicide cases from 2007 – 2010, young white males were more at risk than any other demographic. This study, out today, will be published in Armed Forces & Society, a SAGE journal published on behalf of the Inter-University Seminar on Armed Forces and Society.

BEER-SHEVA, Israel, February 21, 2013 -- Rocket attacks in Sderot, Israel significantly increase the likelihood of miscarriages, according to a new study by Ben-Gurion University of the Negev (BGU) researchers.

PITTSBURGH—At a time when the U.S. government is contemplating changes to federal guidelines governing research with humans, serious questions are being raised about the role of Institutional Review Boards (IRBs) in overseeing such research. Particularly, vocal critics have cited lost time, money and even lives under a system that they claim consumes scarce resources and stifles academic freedom. In response, defenders of the IRB system point to the need to protect research participants from abuse.