Body

Family ties that bind: Having the right surname sets you up for life

If your surname reveals that you descended from the "in" crowd in the England of 1066--the Norman Conquerors--then even now you are more likely than the average Brit to be upper class. To a surprising degree, the social status of your ancestors many generations in the past still exerts an influence on your life chances, say Gregory Clark of the University of California, Davis, in the US and Neil Cummins of the London School of Economics in the UK. They used the Oxbridge attendance of people with rare English surnames (last names) to track social mobility from 1170 to 2012.

Clues to trees' salt tolerance found in native habitat, leaf traits

LOGAN, UT - Urban landscape plants are often subjected to environmental conditions well beyond those of their native habitat. Differences in precipitation, along with stress caused by increased salinity resulting from irrigation with brackish reclaimed water, can have devastating impacts on trees and plants. Use of salt-tolerant species and implementation of proper management strategies can reduce the incidence of plant stress and loss.

Worldwide ship traffic up 300 percent since 1992

WASHINGTON, DC--Maritime traffic on the world's oceans has increased four-fold over the past 20 years, likely causing more water, air and noise pollution on the open seas, according to a new study quantifying global ship traffic.

The research used satellite data to estimate the number of vessels on the ocean every year between 1992 and 2012. The number of ships traversing the oceans grew by 60 percent between 1992 and 2002. Shipping traffic grew even faster during the second decade of the study, peaking at rate of increase of 10 percent per year in 2011.

microRNA silencing provides a successful new model for cancer therapeutics

BOSTON - Since the discovery that microRNAs play key roles in regulating human disease, the hope has been that these short non-coding RNA molecules could be translated into a therapeutic strategy for the treatment of cancer. But this promising application has been significantly hampered by a number of physiological and cellular barriers that prevent microRNA-based therapies from actually reaching tumor cells.

Chemical disguise transforms RNAi drug delivery

Small pieces of synthetic RNA trigger a RNA interference (RNAi) response that holds great therapeutic potential to treat a number of diseases, especially cancer and pandemic viruses. The problem is delivery -- it is extremely difficult to get RNAi drugs inside the cells in which they are needed. To overcome this hurdle, researchers at University of California, San Diego School of Medicine have developed a way to chemically disguise RNAi drugs so that they are able to enter cells.

Unveiling the effects of an important class of diabetes drugs

BOSTON - A research team led by Brigham and Women's Hospital (BWH) and Dana-Farber Cancer Institute (DFCI) has uncovered surprising new findings that underscore the role of an important signaling pathway, already known to be critical in cancer, in the development of type 2 diabetes.

Ferret genome sequenced, holds clues to respiratory diseases

In what is likely to be a major step forward in the study of influenza, cystic fibrosis and other human diseases, an international research effort has a draft sequence of the ferret genome. The sequence was then used to analyze how the flu and cystic fibrosis affect respiratory tissues at the cellular level.

UTSW cancer researchers identify gene mutations and process for how kidney tumors develop

DALLAS - November 17, 2014 - Using next generation gene sequencing techniques, cancer researchers at UT Southwestern Medical Center have identified more than 3,000 new mutations involved in certain kidney cancers, findings that help explain the diversity of cancer behaviors.

TopBP1 a sweet spot for treatment in multiple cancers

HOUSTON -- (Nov. 17, 2014) - A compound called calcein may act to inhibit topoisomerase IIβ-binding protein 1 (TopBP1), which enhances the growth of tumors, said researchers from Baylor College of Medicine in a report that appears online in the journal Nature Communications.

A new genetic cause for a progressive form of epilepsy identified

A study led by researchers at University of Helsinki, Finland and Universities of Melbourne and South Australia has identified a new gene for a progressive form of epilepsy. The findings of this international collaborative effort have been published today, 17 November 2014, in Nature Genetics.

Metabolic 'reprogramming' by the p53 gene family leads to tumor regression

Scientists have found that altering members of the p53 gene family, known as tumor suppressor genes, causes rapid regression of tumors that are deficient in or totally missing p53. Study results suggest existing diabetes drugs, which impact the same gene-protein pathway, might be effective for cancer treatment.

Three popular daffodil varieties determined to be highly salt tolerant

BALTIMORE, MD - As the world's diminishing fresh water resources are increasing allocated for human use, agricultural and horticultural production operations must rely more often on the use of brackish, saline, or reclaimed water for irrigation. These saline-rich water sources often contain electrical conductivities that can negativity affect plants' ability to thrive. Salinity is particularly problematic for ornamental plants such as daffodils because of the potential for damage to plants' aesthetics and visual qualities.

Three new ornamental dogwoods introduced

KNOXVILLE, TN -- In the nursery and landscape industries, flowering dogwood (Cornus florida), kousa dogwood (Cornus kousa), and their hybrids are the most popular and economically significant members of the genus Cornus. The deciduous trees are highly valued for their spring display of pink, red, or white bracts, brilliant red fall foliage, and exfoliating bark. In the United States alone, retail and wholesale sales of dogwoods account for more than $30 million dollars annually.

Side effects of possible anti-cancer strategy discovered

This news release is available in German.

Women's fertility linked to detox element in diet

University of Adelaide research has for the first time shown how much of a critical role the natural antioxidant selenium plays at the earliest stages of a woman's fertility.

The discovery has been made in joint research involving the University's School of Chemistry and Physics and the Robinson Research Institute.