Body

Some patients with non-small cell lung cancer (NSCLC) have changes in the anaplastic lymphoma kinase (ALK) gene, which can drive the development of their cancer. A drug recently developed by Pfizer, crizotinib, targets ALK and is currently given to patients with ALK positive lung cancer when their cancer has worsened after initial chemotherapy. Now doctors have investigated the use of crizotinib in patients with ALK positive lung cancer who have not yet received any chemotherapy treatment.

Scientists at Nanyang Technological University (NTU Singapore) and Penn State University in the United States have successfully discovered one of modern human's ancient lineages through the sequencing of genes.

World-renowned geneticist from NTU, Professor Stephan Christoph Schuster, who led an international research team from Singapore, United States and Brazil, said this is the first time that the history of mankind populations has been analysed and matched to Earth's climatic conditions over the last 200,000 years.

A new, innovative "dashboard" from the National Institute of Standards and Technology (NIST) won't help you drive your car, but it will help enable reproducible research in biology.

Scientists from the Institute of Zoology with the Chinese Academy of Sciences have devoted years of their careers to study the astounding diversity hidden in the depths of the Xishuangbanna tropical rain forests. In a recent paper published in the open access journal ZooKeys Prof. Shuqiang Li and his team reveal 30 new spider species, which constitutes a minor share of what is yet to be found in this biodiversity hotspot.

Los Angeles, CA (Nov 4, 2014) Most women can make all the milk their baby needs, but some mothers turn to medications to help increase their supply. While some specialists encourage the off-label use of domperidone to stimulate breast milk production, some studies have suggested it may be related to negative side effects, including irregular heartbeat and sudden cardiac death. In a new article out today, researchers concluded that although domperidone can increase breast milk production, and there is no known risk to the babies who drink the milk, risks to women are still worrying.

Cancers are due to genetic aberrations in certain cells that gain the ability to divide indefinitely. This proliferation of sick cells generates tumors, which gradually invade healthy tissue. Therefore, current therapies essentially seek to destroy cancer cells to stop their proliferation.

This news release is available in French.

It has been a long held belief that tumors arising from exposure to asbestos are caused by mutations in one cell, which then produces multiple clones. This hypothesis is challenged by new research published in the open access Journal of Translational Medicine, which suggests it is caused by mutations in multiple cells.

Some previous studies have linked the diabetes medication pioglitazone to bladder cancer. However a new study − including more than one million people in six populations worldwide − has found no link between either pioglitazone or rosiglitazone (also known as Avandia) and bladder cancer. The new study is published in Diabetologia (the journal of the European Association for the Study of Diabetes), and is by Dr Samira Bell, Professor Helen Colhoun and Mr Danny Levin, University of Dundee, UK, and colleagues from the International Diabetes and Cancer Research Collaboration.

Researchers at the National Institutes of Health have found a duplication of a short stretch of the X chromosome in some people with a rare disorder that causes excessive childhood growth. They believe that a single gene within the region likely has a large influence on how much children grow. The research comes from a lab at NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which seeks to understand growth.

CHICAGO --- The longer the duration of surgery, the higher the risk of a life-threatening blood clot, according to the first large-scale, quantitative national study of the risk across all surgical procedures.

The Northwestern Medicine study was published Dec. 3 in JAMA Surgery, the Journal of the American Medical Association.

New Orleans, LA - A multi-institutional study reports an effective treatment approach to inhibit and keep latent viruses like herpes simplex from reactivating and causing disease. The work, whose lead author is the late James Hill, PhD, LSU Health New Orleans Professor and Director of Pharmacology and Infectious Disease at the LSU Eye Center, is published in the December 3, 2014, issue of Science Translational Medicine.

An enzyme that usually triggers strong allergic reactions now circulates in the veins of a group of mice without alerting the immune system. As INRS Énergie Matériaux Télécommunications Research Centre Professor Marc A. Gauthier explains in an article published in the journal Nature Communications, a polymer was used to camouflage the enzyme before it was injected into the rodents. This was achieved by coating the enzyme to avoid an immune response in a manner that does not compromise its activity.

Alcohol use is a major risk factor for head and neck cancer. But an article published in the November issue of the journal Advances in Experimental Medicine and Biology shows that the chemical resveratrol found in grape skins and in red wine may prevent cancer as well.

As the two foolish pigs learned before running to their brother's solidly built house of bricks for safety, when the wolf comes calling, the quality of your shelter is everything.

Animals in the wild have always instinctively known this. But changes to their habitat in the wake of human encroachment, climate change and a variety of environmental influences are affecting the predator-prey relationship and creating new "fearscapes" dotted with predation risks.