Body

A large study of the daughters of women who had been given DES, the first synthetic form of estrogen, during pregnancy has found that exposure to the drug while in the womb (in utero) is associated with many reproductive problems and an increased risk of certain cancers and pre-cancerous conditions. The results of this analysis, conducted by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and collaborators across the country, were published Oct. 6, 2011, in the New England Journal of Medicine.

Though viruses are the most abundant life form on Earth, our knowledge of the viral universe is limited to a tiny fraction of the viruses that likely exist. In a paper published this week in the online journal mBio, researchers from the University of Pittsburgh, Washington University in St. Louis, and the University of Barcelona found that raw sewage is home to thousands of novel, undiscovered viruses, some of which could relate to human health.

ST. PAUL, Minn. – People who rate their health as poor or fair appear to be significantly more likely to develop dementia later in life, according to a study published in the October 5, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Two decades after the Americans with Disabilities Act went into effect, people with disabilities continue to face difficulties meeting major social needs, including obtaining appropriate access to health care facilities and services. In an article in the October issue of Health Affairs, Lisa Iezzoni, MD, director of the Mongan Institute for Health Policy at Massachusetts General Hospital, analyzes available information on disparities affecting people with disabilities and highlights barriers that continue to restrict their access to health services.

New Rochelle, NY, October 5, 2011 -- Obesity among adolescents has more than tripled over the past 40 years, and recent estimates find that over 18% of teens in the U.S. are obese.

A Johns Hopkins Children's Center study of young people with melanoma, a deadly form of skin cancer, has found that some children have a higher risk of invasive disease than adults.

The study, published online Oct. 5 in the journal Cancer, is believed to be the first to compare disease spread in children and adults, and the results suggest some profound biological differences between childhood and adult melanoma, the researchers say.

Researchers from Mount Sinai School of Medicine have found high levels of food toxins called Advanced Glycation End products (AGEs) in infants. Excessive food AGEs, through both maternal blood transmission and baby formula, could together significantly increase children's risk for diseases such as diabetes from a very young age. A second study of AGEs in adults found that cutting back on processed, grilled, and fried foods, which are high in AGEs, may improve insulin resistance in people with diabetes.

"Wash away my troubles, wash away my pain," goes the song. Is there such a thing as soap and water for the psyche? Yes: Metaphor is that powerful, say Spike W.S. Lee and Norbert Schwarz of the University of Michigan in a literature review appearing in the latest issue of Current Directions in Psychological Science, a journal published by the Association for Psychological Science.

STANFORD, Calif. — Carefully tracking the rate of response of human lung tumors during the first weeks of treatment can predict which cancers will undergo sustained regression, suggests a new study by researchers at the Stanford University School of Medicine.

Cold Spring Harbor, N.Y. – A new study from Cold Spring Harbor Laboratory (CSHL) reports surprising results that suggest that the devastating neuromuscular disease, spinal muscular atrophy (SMA), might not exclusively affect the motor neurons in the spinal cord as has long been thought. The new findings suggest that defects in peripheral tissues such as liver, muscle, heart, etc., might also contribute to the pathology of the disease in severely affected patients.

Women donating their eggs for use in fertility clinics are typically financially compensated for the time and discomfort involved in the procedure. However, guidelines established by the National Academy of Sciences (NAS) in 2005 state that women who donate their eggs for use in stem cell research should not be compensated, although the procedures they undergo are the same.

Conditions like atherosclerosis and age-related macular degeneration (AMD) -- the most common cause of blindness among the elderly in western societies -- are strongly linked to increased oxidative stress, the process in which proteins, lipids and DNA damaged by oxygen free radicals and related cellular waste accumulate, prompting an inflammatory response from the body's innate immune system that results in chronic disease.

Why are some places more prone to bribery and corruption than others? Part of the answer seems to be the level of collective feeling in a society, according to research by Pankaj Aggarwal, University of Toronto Scarborough (UTSC) professor of marketing in the Department of Management, and Nina Mazar, University of Toronto professor of marketing.

CHAMPAIGN, Ill. — Scientists call it LUCA, the Last Universal Common Ancestor, but they don't know much about this great-grandparent of all living things. Many believe LUCA was little more than a crude assemblage of molecular parts, a chemical soup out of which evolution gradually constructed more complex forms. Some scientists still debate whether it was even a cell.

New evidence suggests that LUCA was a sophisticated organism after all, with a complex structure recognizable as a cell, researchers report.

The anaerobic oxidation of ammonia (anammox) is an important pathway in the nitrogen cycle that was only discovered in the 1980s. Currently, scientists estimate that about 50 percent of the nitrogen in the atmosphere is forged by this process. A group of specialized bacteria perform the anammox reaction, but so far scientists have been in the dark about how these bacteria could convert ammonia to nitrogen in the complete absence of oxygen. Now, 25 years after its discovery, they finally solved the molecular mechanism of anammox.