Body

New drug delivery systems, solar cells, industrial catalysts and video displays are among the potential applications of special particles that possess two chemically distinct sides. These particles are named after the two-faced Roman god Janus and their twin chemical faces allow them to form novel structures and new materials.

Professor Handong Liangfrom State Key Laboratory of Coal Resources and Safe Mining, China University of Mining and Technology Beijing and his group demonstrate that hydrogen fluoride is the prior releasing form of fluorine in long-term air-exposed coal under combustion and mild heating, which may change current understanding of the cause and prevailing mechanism of coal burning endemic fluorosis.

Irvine, Calif., Sept. 30, 2011 — A glucosamine-like dietary supplement suppresses the damaging autoimmune response seen in multiple sclerosis, according to a UC Irvine study.

UCI's Dr. Michael Demetriou, Ani Grigorian and others found that oral N-acetylglucosamine (GlcNAc), which is similar to but more effective than the widely available glucosamine, inhibited the growth and function of abnormal T-cells that in MS incorrectly direct the immune system to attack and break down central nervous system tissue that insulates nerves.

A combination of an oral drug, called sorafenib, and a method for injecting microbeads of chemotherapy directly into tumors has been proven safe for liver cancer patients and may improve outcomes for those who have these fast-growing, deadly tumors whose numbers are on the rise in the U.S.

Athens, Ga. -- University of Georgia scientists have found that smaller, less toxic amounts of chemotherapy medicine given frequently to mice with human prostate cancer noticeably slowed tumor growth. The mice suffered fewer side effects compared with traditional cancer treatment relying on heavy doses that can cause hair and bone loss.

TAMPA, Fla. (Sept. 29, 2011) – Researchers at the Moffitt Cancer Center in Tampa, Fla., and colleagues have found that tumor cell resistance to a specific cancer immunotherapy designed to kill cancer cells can be blamed on a mechanism that involves the production of a free radical peroxynitrite (PNT) that causes resistance to therapeutic cancer-killing cells.

A team of Russian veterinary colleagues and health experts from the Wildlife Conservation Society's Bronx Zoo are collaborating to understand how distemper -- a virus afflicting domestic dogs and many wildlife species -- may be a growing threat to Siberian (Amur) tigers.

The team presented its results at the first-ever Russian symposium on wildlife diseases held this week in the Russian Far East city of Ussurisk. The symposium underscores the growing recognition of the importance of the health sciences to successful wildlife conservation efforts.

Psychiatric ailments such as depression, obsessive-compulsive disorder or anxiety states are often associated with disturbances in the metabolism of the neurotransmitter serotonin. Neurotransmitters are compounds that are released from the synapses at nerve cell endings and activate the firing of neighboring neurons. Thus, as their name suggests, they mediate the transmission of nerve impulses. The serotonin transporter (SERT) is responsible for reuptake of the transmitter into neurons, terminating its action.

Harsh living conditions caused by major fluctuations in the carbon content and sea levels, overacidification and oxygen deficiency in the seas triggered the largest mass extinction of all time at the end of the Permian era 252 million years ago. Life on Earth was also anything but easy after the obliteration of over 90 percent of all species: Throughout the entire Early Triassic era, metazoan-dominated reefs were replaced by microbial deposits. Researchers had always assumed it took the Earth as long as five million years to recover from this species collapse.

Researchers at the Swedish medical university Karolinska Institutet have discovered a new inherited disorder that causes severe mental retardation and liver dysfunction. The disease, adenosine kinase deficiency, is caused by mutations in the ADK gene, which codes for the enzyme adenosine kinase.

A central element of the immune system has remained constant through more than 400 million years of evolution, according to new research at National Jewish Health. In the September 29, 2011, online version of the journal Immunity, the researchers report that T-cell receptors from mice continue to function even when pieces of shark, frog and trout receptors are substituted in. The function of the chimeric receptors depends on a few crucial amino acids, found also in humans, that help the T-cell receptor bind to MHC molecules presenting antigens.

New research analyses maternal breastfeeding in Spain throughout the second half of the twentieth century. Experts believe that its development is associated with socio-demographic factors such as the advice of healthcare professionals, longer maternity leave, a woman's integration into the workplace and her level of education.

Alcohol is known to worsen the effects of disease, resulting in longer recovery period after trauma, injury or burns. It is also known to impair the anti-viral immune response, especially in the liver, including response against Hepatitis C (HCV) and HIV.

EMBARGO: Thursday 29 September 2011, 2pm Pacific/5pm Eastern Time

A research team at the Hubrecht Institute, Utrecht, demonstrates a mechanism by which left–right asymmetry in the body is established and maintained. The study, published in the open-access journal PLoS Genetics on September 29, offers a new model of how families of genes interact to promote and direct body asymmetry.

The largest-ever analysis of genetic data related to type 1 diabetes has uncovered new genes associated with the common metabolic disease, which affects 200 million people worldwide. The findings add to knowledge of gene networks involved in the origin of this complex disorder, in which patients depend on frequent insulin injections to control their blood sugar levels.