Body

Chromosome inheritance? Not the same for all the chromosomes

New findings of researchers from the University of Modena and Reggio Emilia by Mauro Mandrioli, Valentina Monti and Gian Carlo Manicardi show that in aphids the two X chromosomes have a different inheritance.

Aphids are insects with a sex determination model based on the presence of two X chromosomes (XX) in females and a single X chromosome (XO) in males. Previous studies suggested that X chromosome loss during male determination was random and that both X chromosomes have the same probability to be inherited in males.

Why anti-rejection drugs for transplant patients cause hypertension

PORTLAND, Ore. — Modern medicine's ability to save lives through organ transplantation has been revolutionized by the development of drugs that prevent the human body from rejecting the transplanted organ.

But those antirejection drugs have their own side effects — sometimes serious.

Prague's 88 nature reserves threatened by invasive plant species

Cities are generally regarded as hostile for wildlife and urbanization a dramatic form of destruction of natural habitats. Still, they are far from dead zones. Their biodiversity may even exceed that of surrounding landscapes, owing to heterogeneous environments and frequent localization in naturally rich areas that historically supplied diverse resources for their human inhabitants.

Study tracks mutations causing CDA II back to the Roman Empire

Many of you might know that Congenital Dyserythropoietic Anemia type II (CDA II) is a rare blood disorder, due to a failure in final part of erythropoiesis. What will surprise you is the fact that some mutations responsible for the disease can be tracked 3.000 years back. A study led by the ENERCA member Prof.

Gray jays' winter survival depends on food storage, study shows

A new University of Guelph study shows that gray jays hoping to survive and reproduce through Canada's harsh winters need to be able to store food in the right kinds of trees.

The study appears in Oecologia and was co-authored by Prof. Ryan Norris, Department of Integrative Biology; Brian Kielstra, an undergraduate student in the Department of Geography; and Dan Strickland, retired chief naturalist of Algonquin Park in Ontario.

Bone marrow cells migrate to tumors and can slow their growth

Philadelphia, PA, October 6, 2011 – Bone marrow-derived cells (BMDCs) participate in the growth and spread of tumors of the breast, brain, lung, and stomach. To examine the role of BMDCs, researchers developed a mouse model that could be used to track the migration of these cells while tumors formed and expanded. Their results, published in the November issue of The American Journal of Pathology, strongly suggest that more effective cancer treatments may be developed by exploiting the mechanism by which bone marrow cells migrate to tumors and retard their proliferation.

Market transactions and economics in general affect biological invasions

Biological invasions, i.e. the spread of introduced, non-native species, not only serve as ecological model systems, but also bring out the importance of economic activities on ecological processes. Two recent books have shown the extent and variety of the interaction of economics with invasion science and also the variety of approaches to tackling these problems.

'Non-invasive' cultivar? Buyer beware

Cultivars of popular ornamental woody plants that are being sold in the United States as non-invasive are probably anything but, according to an analysis by botanical researchers published in the October issue of BioScience. Tiffany M. Knight of Washington University in St. Louis, Missouri, and her coauthors at the Chicago Botanic Garden write that the claims of environmental safety are in most cases based on misleading demographic evidence that greatly underestimates the plants' invasive potential.

Genetic makeup affects testosterone concentrations in men

Genetics play an important role in the variation in, and risk of, low testosterone concentrations in men. A study by the CHARGE Sex Hormone Consortium, published in the open-access journal PLoS Genetics on Thursday, 6th October, is the first genome-wide association study to examine the effects of common genetic variants on serum testosterone concentrations in men.

Pregnant mothers at risk from air pollution

A Californian-based study has looked in detail at air quality and the impact of traffic-related air pollution on premature birth. Published in BioMed Central's open access journal Environmental Health, results from this study show that traffic-related air pollution, especially polycyclic aromatic hydrocarbons (PAH), is associated with up to a 30% increase in premature births, and that seasonal changes and vicinity to the coast affected concentration of toxic pollutants in the air.

TLR7: Ancient gene found to control potent antibody response to retroviruses

A researcher at MIT's Koch Institute for Integrative Cancer research has identified a gene that controls the process by which antibodies gain their ability to combat retroviruses. Edward Browne shows that the gene TLR7 allows the antibody generating B cells to detect the presence of a retrovirus and promotes a process by which antibodies gain strength and potency, called a germinal center reaction. The findings are published in the Open Access journal PLoS Pathogens on October 6th.

Concern over accuracy of suicide rates in England and Wales

The increasing use of "narrative verdicts" by coroners in England and Wales may be leading to greater underestimation of suicide rates, warn experts on bmj.com today, based on ongoing research part funded by the National Institute for Health Research (NIHR).

Professor David Gunnell at the University of Bristol and colleagues from the Universities of Oxford and Manchester say changes are needed urgently to ensure the future reliability of national suicide statistics.

Study first to link mitochondrial dysfunction and alpha-Synuclein multiplication in human fibroblasts

Amsterdam, NL, 7 October 2011 – A new study in the Journal of Parkinson's Disease shows for the first time the effects of α-Synuclein (α-syn) gene multiplication on mitochondrial function and susceptibility to oxidative stress in human tissue. Mitochondrial dysfunction has been frequently implicated in the neurodegenerative process that underlies Parkinson's disease, but the basis for this has not been fully understood.

Decade of effort yields diabetes susceptibility gene

MADISON – Ten years of meticulous mouse breeding, screening, and record-keeping have finally paid off for Alan Attie and his lab members.

The University of Wisconsin–Madison researchers' efforts, published Oct. 6 in the journal PLoS Genetics, pinpointed a gene that confers diabetes susceptibility in obese mice.

They also showed that the protein coded by the gene, called tomosyn-2, acts as a brake on insulin secretion from the pancreas.

Diabetes susceptibility gene identified: Tomosyn-2 regulates insulin secretion

A group of researchers from the University of Wisconsin–Madison has pinpointed a gene that confers diabetes susceptibility in obese mice. Published on October 6th in the open-access journal PLoS Genetics, this study also shows that its protein tomosyn-2 acts as a brake on insulin secretion from the pancreas.

"It's too early for us to know how relevant this gene will be to human diabetes," says Alan Attie, who leads the group, "but the concept of negative regulation is one of the most interesting things to come out of this study and that very likely applies to humans."