Body

Bench to bassinet program seeks congenital heart disease treatments

What: To help speed the translation of scientific discoveries into usable treatments in congenital heart disease, the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health launched the Bench to Bassinet Program (http://www.benchtobassinet.net/). This program, which involves several major research institutions across the country, will be highlighted in the March 23 edition of the Journal of the American College of Cardiology.

Gene expression-based prognostic signatures in lung cancer not ready for clinical use

A review of published articles on gene expression-based prognostic signatures in lung cancer revealed little evidence that any of the signatures are ready for clinical use. Serious problems in the design and analysis of the studies were also found. The review was published online March 16, 2010 in the Journal of the National Cancer Institute.

Blocking cancer in its path: New cellular defect discovered

UCSF researchers have discovered that a key cellular defect that disturbs the production of proteins in human cells can lead to cancer susceptibility. The scientists also found that a new generation of inhibitory drugs offers promise in correcting this defect.

According to the study team, this discovery has broad clinical implications in the fight against cancer and could affect treatment of lymphoma and many other forms of the disease, including prostate cancer, breast cancer, colorectal cancer, brain cancer and multiple myeloma.

ID physicians call for 10 new antibiotics by 2020

Arlington, Va. —As the deaths and suffering caused by antibiotic-resistant bacterial infections continue to rise around the world, the Infectious Diseases Society of America (IDSA) is urging a global commitment to develop 10 new antibiotics by 2020, known as the 10 x '20 initiative, to address this public health crisis and safeguard patients' health.

Preventive behaviors limited household transmission of H1N1 influenza during initial outbreak

Simple, common sense behaviors, including having a discussion at home about how to prevent influenza, can help limit the spread of H1N1 in a household, according to a study of the initial outbreak in New York City in 2009. Published in the April 1 issue of The Journal of Infectious Diseases, the study is available online (http://www.journals.uchicago.edu/doi/abs/10.1086/651145).

As girth grows, risk of sudden cardiac death shrinks

Obesity has long been identified as a risk factor for cardiovascular disease and heart failure. But, a new study conducted by researchers at the University of Rochester Medical Center found that being skinny confers no advantage when it comes to the risk of dying suddenly from cardiac causes.

New TB booster shows promise

A booster shot appears to improve tuberculosis (TB) resistance in previously vaccinated adults, according to new research in South Africa.

The study has been published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

Rare armor-plated creature discovered in Canada's capital

Scientists have unearthed the remains of one of the Worlds rarest fossils - in downtown Ottawa. The 450 million year old fossil preserves the complete skeleton of a plumulitid machaeridian, one of only 8 such specimens known. Plumulitids were annelid worms - the group including earthworms, bristleworms and leeches, today found everywhere from the deepest sea to the soil in your yard - and although plumulitids were small they reveal important evidence of how this major group of organisms evolved.

Jaws -- 4 million BC

It might sound like a mashup of monster movies, but palaeontologists have discovered evidence of how an extinct shark attacked its prey, reconstructing a killing that took place 4 million years ago.

Such fossil evidence of behaviour is incredibly rare, but by careful, forensic-style analysis of bite marks on an otherwise well-preserved dolphin skeleton, the research team, based in Pisa, Italy, have reconstructed the events that led to the death of the dolphin, and determined the probably identity of the killer: a 4 m shark by the name of Cosmopolitodus hastalis.

Caltech and UCSD scientists establish leech as model for study of reproductive behavior

PASADENA, Calif.—Researchers at the California Institute of Technology (Caltech) and the University of California, San Diego (UCSD) have discovered that injecting a simple hormone into leeches creates a novel way to study how hormones and the nervous system work together to produce species-specific reproductive behavior.

A paper describing the work appears in the March 11 online edition of the journal Current Biology.

From international harbor to native habitat

In the 1930s, soil used as ballast to weigh down cargo ships from South America to Mobile, Alabama introduced the red imported fire ant to the southern United States. Since then, the ants have been found as far north as Maryland and as far west as California, shorting out streetlights and eating through crops and native plants in the process.

Scientists urge treaty panel to reject ivory sale by Tanzania, Zambia

The fate of many African elephants, according to a group of scientists, hinges on a decision to be made this week in Qatar by a host of countries operating under an international agreement.

The countries, part of the Convention on International Trade in Endangered Species (CITES), are gathering to decide, among other proposals, whether to grant requests to Tanzania and Zambia to lower the protection status of their elephants, allowing them to conduct one-time sales of stockpiled ivory.

Cloves are the best natural antioxidant

Using spices eaten in the Mediterranean diet as natural antioxidants is a good way forward for the food industry, given the beneficial health effects of these products. This has been shown by researchers from the Miguel Hernández University (UMH), who have put the clove in first place.

Researchers from the Miguel Hernández University have identified cloves (Syzygium aromaticum) as the best antioxidant spice, due to the fact they contain high levels of phenolic compounds, as well as having other properties.

Long polymer chains dance the conga

CHAMPAIGN, Ill. — Understanding the steps to the intricate dance inside a cell is essential to one day choreographing the show. By studying the molecules that give a cell its structure, University of Illinois researchers are moving closer to understanding one of those steps: the conga line.

SBRT eliminates tumors with promising survival for early-stage inoperable lung cancer patients

Philadelphia – Highly-focused stereotactic body radiation therapy (SBRT) can eliminate the targeted tumor while avoiding treatment-related illness and may ultimately improve survival for patients with inoperable non-small cell lung cancer, according to early findings of a Radiation Therapy Oncology Group study published in the March 17 cancer-themed issue of the Journal of the American Medical Association.