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Yerkes NPRC/Emory University and Institut Pasteur researchers have determined adding a combination immunotherapy to antiviral therapy (ART) is effective in generating highly functional natural killer (NK) cells that can help control and reduce simian immunodeficiency virus (SIV) in animal models. This finding is key for reducing reliance on ART and developing additional treatment options to control HIV/AIDS.

Researchers at the University of Adelaide have found several grape varieties native to Cyprus, which tolerate drought conditions better than some international varieties popular in Australia, contain chemical compounds responsible for flavours preferred by Australian consumers.

Despite lower exercise volume, HIIT was as effective as endurance running for improving exercise capacity and spatial memory. Researchers at the University of Tsukuba found that activity-specific physiological adaptations in the muscles and increased signaling and neurogenesis in the hippocampus underlie these improvements. Findings also suggested that benefits can potentially be optimized by tailoring exercise time and intensity.

Japanese researchers have discovered that cysteinylated albumin (oxidized albumin) in serum can be used as an early diagnostic marker for diabetic kidney disease. Compared with urinary albumin, serum oxidized albumin not only reflects renal pathology at an earlier stage, but can also predict the progression of renal pathology by its degree of elevation. The researchers believe that it can be used as a new diagnostic marker for early diagnosis of diabetic kidney disease.

Scientists from Hokkaido University have used species survey and climate data to identify two marine biodiversity refugia in the Eastern Bering Sea - regions where species richness, community stability and climate stability are high.

A new study led by KAIST researchers using fruit flies reveals how protein deficiency in the diet triggers cross talk between the gut and brain to induce a desire to eat foods rich in proteins or essential amino acids. This finding reported in the May 5 issue of Nature can lead to a better understanding of malnutrition in humans.

An international team of researchers has analyzed the function of the histone demethylase KDM5A in multiple myeloma, one of the three major hematological cancers, and clarified the mechanism by which it promotes myeloma cell proliferation. They also developed a novel KDM5 inhibitor and showed that it inhibits cancer cell growth in a myeloma mouse model. The researchers expect that new therapies targeting KDM5A will be developed in the future.

A rare syndrome has been observed in people following vaccination against Covid-19. This involves thrombosis at unusual sites in the body, associated with a low thrombocyte count and a clotting disorder. In medical jargon, this syndrome is referred to as VITT (vaccine-induced thrombotic thrombocytopenia). Doctors at MedUni Vienna and Vienna General Hospital have now successfully treated an acute instance of this syndrome.

The Oncotarget article provides evidence that antitumor activity and prolonged stable disease are achieved with Z-endoxifen despite prior tamoxifen therapy.

CABYR expression in tumors was further confirmed by immunohistochemistry

A team of McMaster University researchers who studied heart patients found that stair-climbing routines, whether vigorous or moderate, provide significant cardiovascular and muscular benefits.

The Oncotarget authors propose a model of how the specific remodeling of cellular metabolism by caloric restriction contributes to yeast chronological aging delay.

The COVID-19 pandemic has, and will continue to have, a tremendous impact on ICU nurses' mental health and willingness to continue in the critical care work force, according to research presented at the ATS 2021 International Conference.

Researchers from Tohoku University have developed a new numerical method that paves the way for simulating landslide tsunamis.

Humans leave their "footprints" on the land area all around the globe. These land-use changes play an important role for nutrition, climate, and biodiversity. Scientists at the Karlsruhe Institute of Technology (KIT) combined satellite data with statistics from the past 60 years and found that global land-use changes affect about 32 percent of the land area. This means that they are about four times as extensive as previously estimated. The researchers publish their findings in the scientific journal Nature Communications.

Rice University researchers have engineered a bacterium capable of diagnosing a human disease, a milestone in the field of synthetic biology.

Oscillatory and rotational motions of different parts are combined in a newly conceived artificial molecule, paving the way for the construction of devices capable of transforming and transmitting movements on the nanometer scale. The nanodevice was designed, synthesized and tested by a team of researchers of the University of Bologna

New research from the Intermountain Healthcare Heart Institute in Salt Lake City finds that higher EPA blood levels alone lowered the risk of major cardiac events and death in patients, while DHA blunted the cardiovascular benefits of EPA. Higher DHA levels at any level of EPA, worsened health outcomes.

A valve invented by engineer Nikola Tesla a century ago is not only more functional than previously realized, but also has other potential applications today, a team of researchers has found after conducting a series of experiments on replications of the early 20th-century design.

Living in rural areas, neighborhoods with lower socioeconomic levels or being of Hispanic ethnicity are associated with lower prenatal detection and later diagnosis of a congenital heart defect known as transposition of the great arteries.Similarly, living in neighborhoods with lower socioeconomic levels was linked with decreased detection of a condition known as hypoplastic left heart syndrome, another type of congenital heart defect.