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SGLT2 inhibitors (gliflozins) are oral anti-diabetic drugs. They not only reduce blood sug-ar, but also improve cardiovascular and renal outcomes -- not only in type 2 diabetics, but also in non-diabetics. This benefit cannot be due to lower blood sugar levels per se; however, it is not yet known how these positive effects are actually mediated. A recent study has now discovered correlations with the hematocrit value.

Climate change represents one of the greatest global health threats of our time. In choosing Healthy Environment, Healthy Kidneys as the theme for the 2021 fully virtual Congress, the ERA-EDTA highlights the central role of nephrologists and other health professionals in advocacy for global efforts to reduce emissions and protect against climate change.

Computer simulations visualize in atomic detail how DNA opens while wrapped around proteins.

Geologic structures and deposits below planetary surfaces can be mapped faster than ever.

The unfolded protein response (UPR) is a pivotal mechanism to mitigate protein homeostasis through transcriptional or translational control. On the other hand, since dysregulation of UPR has been associated with various human diseases, the compounds modulating UPR can clarify the pathological significance of the UPR.

Research from Washington University School of Medicine in St. Louis shows that international travelers often return home with new bacterial strains jostling for position among the thousands that normally reside within the gut microbiome. Such travel is contributing to the rapid global increase and spread of antimicrobial resistance.

An international research team have concluded that increases in extreme rainfall and associated flooding are projected to continue as global temperatures continue to rise. Efforts to limit warming to +1.5C will help limit changes in extreme rainfall, though some societal adaptations will still be required.

Cells/colony motion of oral keratinocytes was non-invasively and quantitatively determined by optical flow algorithm. As per the distinct cell growth kinetics, modified optic flow algorithm was applied with fewer full-screening imaging analyses & cell segmentations, which confirmed the association of proliferative capacity & epithelial regenerative capacity with mean motion speed (MMS). The index of MMS was identified to detect the substandard population, prior to human clinical use, which may be applied to other cell cultures.

The world is one step closer to ultimately secure conference calls, thanks to a collaboration between Quantum Communications Hub researchers and their German colleagues, enabling a quantum-secure conversation to take place between four parties simultaneously.

Researchers recently found a new species of scale worms (Annelida: Polynoidae) living mostly in pairs with a striking difference compared to the almost 900 already known species of scale worms: one was a quarter the size of its mate.

Procedures to prevent the direct transmission of hepatitis B virus (HBV) from mother to child, particularly during and after pregnancy, have significant fragmentation and gaps, a new survey presented at the 6th World Congress of Paediatric Gastroenterology, Hepatology and Nutrition has shown.

(Geneva, 5 June 2021) Mass screening of school-age children has led to significantly higher numbers of coeliac disease cases being diagnosed, according to a new study presented today at the 6th World Congress of Paediatric Gastroenterology, Hepatology and Nutrition.

The June edition of SLAS Technology is a Special Issue entitled, 'Emerging Trends in 3D Cell Culture: High-Throughput Screening, Disease Modeling and Translational Medicine.' Free online access to the articles in this collection is courtesy of Corning Life Sciences, the issue's sponsor.

Individuals with communication disorders report improvement with focus, speech, and motor skills, after using a patented nutritional supplement.

The June edition of SLAS Discovery features the cover article, 'A Perspective on Synthetic Biology in Drug Discovery and Development -- Current Impact and Future Opportunities' by Florian David, Ph.D. (Chalmers University of Technology, Gothenburg, Sweden), Andrew M. Davis, Ph.D. (AstraZeneca, Cambridge, England, UK). Michael Gossing, Ph.D., Martin A. Hayes, Ph.D., and Elvira Romero, Ph.D., and Louis H. Scott, Ph.D. (AstraZeneca, Gothenburg, Sweden), and Mark J. Wigglesworth, Ph.D. (AstraZeneca, London, England, UK).

A new, retrospective study focuses on men who have both high-grade prostate cancer that extends outside the prostate and/or has spread into the lymph nodes. For these men who are at high risk of dying from the disease, there was a significant reduction in the risk of death with adjuvant radiation therapy (aRT) use, suggesting that it should be offered to these men.

Speech rehabilitation experts can predict how well a patient will recover from aphasia, a disorder caused by damage to the part of the brain responsible for producing language.

Most Americans should get screened for colorectal cancer beginning at age 45 instead of age 50, according to new recommendations from the U.S. Preventive Services Task Force, which includes UVA Health's Li Li, MD, PhD, MPH. This recommendation applies to Americans without symptoms who do not have a history of colorectal polyps or a personal or family health history of genetic disorders that increase the risk of colorectal cancer.

A study of more than 1,000 demographically representative participants found that about 22 percent of Americans self-identify as anti-vaxxers, and tend to embrace the label as a form of social identity.

A team led by Carnegie's Thomas Shiell and Timothy Strobel developed a new method for synthesizing a novel crystalline form of silicon with a hexagonal structure that could potentially be used to create next-generation electronic and energy devices with enhanced properties that exceed those of the "normal" cubic form of silicon used today.