Rolapitant reduces nausea and vomiting in patients receiving cisplatin-based chemotherapy, according to the results of a phase III trial presented for the first time today at the ESMO 2014 Congress in Madrid, Spain.
Afatinib, a tyrosine kinase inhibitor, significantly improved progression-free survival compared to methotrexate in patients with recurrent or metastatic squamous cell carcinoma of the head and neck after failure of platinum-based chemotherapy, the results of a phase III trial presented at the ESMO 2014 Congress in Madrid show.
The Lux-Head&Neck 1 trial showed that patients who received treatment with 40 mg/day oral afatinib had a 20% reduction in risk of progression or death compared to patients who received methotrexate, with a median progression-free survival of 2.6 months.
By Tony Westbury, Edinburgh Napier University
Medinah Country Club, Chicago, Ryder Cup 2012. There were six short feet between Martin Kaymer and the 18th hole. This was the moment. No other player, no spectator, none of the many millions watching on television would have dared breathe. The seconds stretched as the German composed himself for his final shot.-->
The public is not aware of this, but academic science is more like a small business than being part of a vast university structure. An investigator is the business owner and the researchers are independent contractors, augmented by graduate students who go to the school.
In that sort of environment, where the life and death of the business is determined by beating other labs for a finite pool of money, while the government spends billions to try and increase the number of competitors who want to be in government-funded academia rather than the private sector, competitive instincts run high.
Sharing data either dilutes the strength of a research group or it allows a competitor to have a shortcut that another lab funded. Lose-lose.
NASA's Aqua satellite captured strong thunderstorms with colder cloud tops that have grown within Tropical Storm Rachel in the Eastern Pacific Ocean.
Aqua passed over the large Tropical Storm Rachel on Sept. 25 at 4:41 p.m. EDT and the Atmospheric Infrared Sounder or AIRS instrument, saw that the extent of colder cloud tops had increased, indicating thunderstorm heights were increasing and it was strengthening. The expansion of those stronger thunderstorms also suggests that the northeasterly wind shear may be relaxing a little. The strongest thunderstorms remain limited to the southwest of the low-level center,
Earth's atmosphere is a complicated dance of molecules involving the output of plants, animals and human industry in sequences of chemical reactions.
Such processes help maintain the atmosphere's chemical balance; most topically during protest week in New York City, they break down pollutants emitted from the burning of fossil fuels.
Understanding exactly how these reactions proceed is critical for predicting how the atmosphere will respond to environmental changes, but some of the steps of this dance are so quick that all of the molecules involved haven't been measured in the wild.
Periodontitis, gum infection that damages the soft tissue and destroys the bone that supports teeth, is the sixth most prevalent condition in the world affecting 743 million people worldwide, according to research from 2010.
Between 1990 and 2010, the global age-standardized prevalence of severe periodontitis was static at 11.2%. The age-standardized incidence of severe periodontitis in 2010 was 701 cases per 100,000 person-years, a non-significant increase from the 1990 incidence of severe periodontitis.
Ryan Rykaczewski, an oceanographer and assistant professor at the University of South Carolina, is part of a team that are looking deep into the ocean's past, and they have shown that natural processes can cause dramatic year-to-year drops in fish populations and growth rates.
They also raise questions about whether human activities might be making those declines more frequent.
Upwelling means phytoplankton, the perfect 'sea food'
The focus of the research is the California current, which stretches from Washington state to the Baja peninsula and is one of a handful of coastal waters on Earth from which an inordinately large portion of the world's fish harvest originates.
Outside the developed world, global population continues to rise but all of the best agricultural locations are in use. If we want people to be self-sufficient (and we do) science is going to need to be able to help the developing world with innovative and sustainable solutions.
Modern agriculture has not reached any kind of limit, we can easily boost food production by as much as 70-100% in the next few decades. To grow in more difficult areas, and to be resistant to swings in weather, more drought-tolerant food crops are essential.
(Inside Science) -- Scientists today released 2,000 South American parasitic wasps in Indonesia as part of a project aimed at thwarting an invasive insect pest that is devastating the country’s cassava food crop.-->
By Robin Wylie, University College London-->
The government says the unemployment level is back at 2009 levels - but they use a metric that no one outside government would consider valid, namely how many people collect unemployment checks.
After people have been unemployed past the expiration of the checks, the government claims they must be employed. In reality, many are not. The Great Recession limps along regardless of how the 1 % are doing in the stock market and what government public relations claims are.
In reality, 20 percent of workers laid off from a job during the last five years are still unemployed and looking for work, researchers from the John J. Heldrich Center for Workforce Development at Rutgers have found.
The very small is very weird; I explained that the last time in Small Is Ugly 1 already with help of the example of water being in the driest of places (Vastness and Fastness of the Small helps Evolution is of course somewhat related). And today, I still do not mean supposed "quantum weirdness", which is not about small stuff.-->
There's a common trope in Hollywood celebrities who gain weight and receive attention for it. They talk about how much healthier and better they feel about themselves at higher weight - and then they immediately lose weight and talk about how much healthier and better they feel about themselves.
Severely obese people who aren't famous also experience much better spirits once they shed weight through diet, lifestyle changes or medical intervention but Valentina Ivezaj and Carlos Grilo of the Yale University School of Medicine write in Obesity Surgery that it is not a psychological magic bullet.
Antidepressants are the most commonly used treatment for social anxiety disorder but we know they don't work for many people and their efficacy goes down over time.
New research finds they are not even needed in many instances.
Social anxiety disorder is a condition characterized by fear and avoidance of social situations. It affects as many as 13 percent of the Western world. For most people, it is not severe, and they never receive treatment for the disorder but those who do get treatment are usually assigned medication.
The appeal of artificial photosynthesis, in which the electrochemical reduction of carbon dioxide is used to produce clean, green and sustainable fuels, is that we can turn an atmospheric byproduct into a renewable energy technology.
However, finding a catalyst for reducing carbon dioxide that is highly selective and efficient has proven to be a huge scientific challenge.
Peidong Yang, a chemist with Berkeley Lab's Materials Sciences Division, led a study in which bimetallic nanoparticles of gold and copper were used as the catalyst for the carbon dioxide reduction. The results experimentally revealed for the first time the critical influence of the electronic and geometric effects in the reduction reaction.