Tech

Frequency Comb' Technique Reveals Colors And Intensity Of All Lightwaves Simultaneously

Physicists at the Commerce Department's National Institute of Standards and Technology (NIST) have taken the first ever two-dimensional pictures of a "frequency comb," providing extra information that enhances the comb's usefulness in optical atomic clocks, secure high-bandwidth communications, real-time chemical analysis, remote sensing, and the ultimate in precision control of atoms and molecules.False-color images of the "fingerprints" of molecular iodine, each taken under different experimental conditions using a NIST frequency brush created with an ult

'Optics On A Chip' May Revolutionize Telecom, Computing

In work that could lead to completely new devices, systems and applications in computing and telecommunications, MIT researchers are bringing the long-sought goal of "optics on a chip" one step closer to market.

Rapid Method For Judging Nanotube Purity Developed

Researchers at the National Institute of Standards and Technology (NIST) have developed a sensitive new method for rapidly assessing the quality of carbon nanotubes.

Using Nano-magnets To Enhance Medical Imaging

Supercomputer Provides Super Tool For Simulation Of Cell Division

Finding May Unshackle The Potential Of Composite Materials

Ultra-Sensitive Measurements Of Changes In Images Using Slow Light

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Mathematics Of Cloaking: New Analysis Improves Methods To Render Objects Invisible

The theorists who first created the mathematics that describe the behavior of the recently announced "invisibility cloak" have revealed a new analysis that may extend the current cloak's powers, enabling it to hide even actively radiating objects like a flashlight or cell phone.

Allan Greenleaf, professor of mathematics at the University of Rochester, working with colleagues around the globe, has announced a mathematical theory that predicts some strange goings on inside the cloak—and that what happens inside is crucial to the cloak's effectiveness.

Bats and Viruses: Why The Wuhan Lab Studied Coronavirus Gain Of Function Using 15,000 Bat Samples

A recent paper tackled a mystery that has puzzled scientists for years;  how the world’s only winged mammals carry viruses that cause severe disease while rarely becoming seriously ill themselves?

One prominent lab that studied them was in Wuhan, China, but they took their database of coronavirus samples offline in late 2019 so scientists in the rest of the world are stuck redoing a lot to try and figure out how it happens. Researchers from the U.S. Centers for Disease Control and academia found that the world’s largest family of bats carry two copies of the genes that produce antibodies that help the immune system recognize and fight infections. Their model was vesper bats, because that family includes over 500 species found on every continent where bats can survive. Antibodies are Y-shaped proteins consisting of two heavy protein chains and two light protein chains. In every other mammal, those heavy chains are built from a single set of gene. Vesper bats instead possess two separate heavy-chain gene systems, which makes it possible for them to generate enhanced antibody diversity. 

The discovery of two distinct copies of proteins that prevent infection opens new avenues for understanding the evolution of immunity and how we respond to disease. Preventing human disease is a key reason why the Obama administration helped fund gain-of-function research in Wuhan back in 2014. They had bat and other animal samples from all across Asia and the world. They were looking closely at adaptive immune systems.

Immunoglobulin heavy chain locus duplication in bats

(A) Schematic of Ig gene annotations for A-IGH locus. (B) Pie chart of functionality and (C) gene family distribution for functional variable (V) genes for A-IGH locus. (D) Density plot of AID hotspots per kilobase in the constant gene encoding regions for A-IGH locus. (E) Schematic of Ig gene annotations for B-IGH locus. (F) Pie chart of functionality and (G) gene family distribution for functional variable genes for B-IGH locus. (H) Density plot of AID hotspots per kilobase in the constant gene encoding regions for B-IGH locus. (I) Nearest neighbor-joining tree of functional and ORF V genes for A-IGH and B-IGH with human V genes collapsed by V-gene family for reference. Created in BioRender. Pursell, T. (2026) https://BioRender.com/rru8vm2.

Genes along can't explain why they are effective viral reservoirs that give disease without catching it but because bats are pollinators and pest controllers their ability to serve as natural hosts for many viruses leads to worry about disease spillover. But bats aren't like Aedes Egyptii mosquitoes, disease vectors that could be wiped out and their ecological value taken up by a million other species, they are important enough we would benefit from coexisting with viruses the way they do.

 

Credit: 
Science Advances

Predicting when an adolescent will become suicidal

One common thing said by friends and family of people who commit suicide is that they didn't see the signs. A new algorithm can, with 91% accuracy.

 

Making skin crawl: using cellular motion to help wound healing

With a technique that overcomes cells’ innate social behaviors, researchers have taken an important step in directing skin cells to migrate en masse to close wounds _ “literally making skin crawl,” said principal investigator Daniel Cohen.

AI Baby Steps: Letting your car detect potholes

An 'AI-based automatic pothole detection system' is designed to be installed on the windshield of a vehicle to detect potholes on the road surface in real-time. Potholes can damage cars and may even lead to life-threatening accidents.

Rabi-oscillation spectroscopy puts exotic matter in our sights

Physicists have created a new way to observe details about the structure and composition of materials that improves upon previous methods. Conventional spectroscopy changes the frequency of light shining on a sample over time to reveal details about them. The new technique, Rabi-oscillation spectroscopy, does not need to explore a wide frequency range so can operate much more quickly. This method could be used to interrogate our best theories of matter in order to form a better understanding of the material universe.

Goal-setting and positive parent-child relationships reduce risk of youth vaping

image: Fellow, Division of Adolescent and Young Adult Medicine, UPMC Children's Hospital of Pittsburgh.

Image: 
UPMC

PITTSBURGH, July 26, 2021 - Adolescents who set goals for their future and those with strong parental support are less likely to use e-cigarettes and other tobacco products, according to a study by UPMC Children's Hospital of Pittsburgh and University of Pittsburgh School of Medicine physician-scientists.

The research, published today in the journal Pediatrics, suggests that strategies to prevent youth vaping may be different from what works to dissuade youth from smoking cigarettes.

"The use of e-cigarettes by young people is at epidemic proportions, with 27% of youth surveyed saying they'd vaped in the last 30 days," said lead author Nicholas Szoko, M.D., a fellow in the Division of Adolescent and Young Adult Medicine at UPMC Children's. "And a lot of the traditional methods we think of for counseling youth on the dangers of tobacco and drug use may not apply to vaping. Pediatricians and parents need a better understanding of what motivates adolescents to eschew e-cigarettes."

Szoko and his colleagues analyzed anonymous questionnaires administered in partnership with the Allegheny County Health Department and completed by 2,487 high school students in Pittsburgh Public Schools. The surveys asked questions to ascertain if and how often the students used e-cigarettes or other tobacco products, and to determine if any of four "protective factors" validated by previous research were associated with a lower likelihood of vaping or smoking.

The protective factors examined were:

Future orientation: A person's beliefs, hopes and goals related to the future.

Parental monitoring: Parent-child interactions and communication.

Social support: The ability to rely on friends and peers.

School connectedness: A sense of belonging and inclusion at school.

In the study, positive future orientation and high levels of parental monitoring were both linked with a 10% to 25% lower prevalence of recently or ever vaping, compared to peers with lower scores on those protective factors. There was no link between social support or school connectedness and use of e-cigarettes.

All four protective factors were associated with lower prevalence of smoking or use of other tobacco products, but none were linked to intent to quit using tobacco products. This suggests that once young people begin to use tobacco, quitting may be more difficult to promote. The researchers note that these findings should be explored to develop improved youth tobacco prevention efforts, but that it isn't surprising that the results for vaping weren't exactly the same as for smoking.

"E-cigarettes are positioned and marketed differently than tobacco cigarettes. They've been popularized as tools for smoking cessation, and previous research has found the various flavors and trendy ads for vaping are attractive to youth," said Szoko. "We also know that vaping primes adolescents to transition to smoking cigarettes and other substance use. So, it stands to reason that we may need different approaches to keep kids from vaping, than we use to stop them from smoking."

Senior author Alison Culyba, M.D., Ph.D., M.P.H., assistant professor of pediatrics, public health, and clinical and translational science at Pitt, noted that frameworks already exist to help clinicians use future orientation and encourage parental monitoring when providing health care to young people, which bodes well for developing e-cigarette intervention programs to strengthen these protective factors.

"Future orientation is something very tangible that pediatricians and other health care providers can talk with teens about in the clinic--motivational interviewing is something we're very comfortable doing with our patients," said Culyba, also an adolescent medicine physician and director of the Empowering Teens to Thrive program at UPMC Children's. "And we can help parents to navigate their roles as their children become pre-teens and teens, and help encourage open conversations with their kids about what they're encountering."

Credit: 
University of Pittsburgh