In this Policy Forum, Phillip Sharp, Tyler Jacks and Susan Hockfield discuss the need for better integration of engineering, physical, computational, and mathematical sciences with biomedical science, as they publish a report this week outlining key recommendations in this space. Convergence of physics and engineering in the 20th century led to a wealth of advancements - radios, telephones, cars, planes, computers, the internet - and, if the correct investments and commitments are in place, the biomedical field is poised for similar advancements, these authors say.