Brain

Sticks and stones: Brain releases natural painkillers during social rejection, U-M study finds

ANN ARBOR, Mich. — "Sticks and stones may break my bones, but words will never hurt me," goes the playground rhyme that's supposed to help children endure taunts from classmates. But a new study suggests that there's more going on inside our brains when someone snubs us – and that the brain may have its own way of easing social pain.

The findings, recently published in Molecular Psychiatry by a University of Michigan Medical School team, show that the brain's natural painkiller system responds to social rejection – not just physical injury.

Molecule produced during exercise boosts brain health

Research has shown that exercise is good for the brain. Now investigators have identified a molecule called irisin that is produced in the brain during endurance exercise and has neuroprotective effects. Researchers were able to artificially increase the levels of irisin in the blood to activate genes involved in learning and memory.

Elephants know what it means to point, no training required

When people want to direct the attention of others, they naturally do so by pointing, starting from a very young age. Now, researchers reporting in Current Biology, a Cell Press publication, on October 10 have shown that elephants spontaneously get the gist of human pointing and can use it as a cue for finding food. That's all the more impressive given that many great apes fail to understand pointing when it's done for them by human caretakers, the researchers say.

Brain development differs in children who stutter

(Edmonton) A new study by a University of Alberta researcher shows that children who stutter have less grey matter in key regions of the brain responsible for speech production than children who do not stutter.

A silent epidemic: Minor traumatic brain injury

ROSEMONT, Ill.—In the United States, approximately 1.4 million people suffer a traumatic brain injury (TBI) each year. Of those injuries, three out of four are minor TBI (mTBI)—a head injury that causes a temporary change in mental status including confusion, an altered level of consciousness, or perceptual or behavioral impairments.

Increased risk of depression linked to mountaintop coal mining

New Rochelle, NY, October 10, 2013—People who live among the destructive environmental effects of mountaintop coal mining face an increased risk of major depression. The results of a study conducted in the coal mining regions of Central Appalachia that explored the relationship between psychological health and environmental degradation are published in Ecopsychology, a peer-reviewed, online journal from Mary Ann Liebert, Inc., publishers.

Correcting emotional misunderstandings

When we are sad the world seemingly cries with us. On the contrary, when we are happy everything shines and all around people's faces seem to rejoyce with us. These projection mechanisms of one's emotions onto others are well known to scientists, who believe they are at the core of the ability to interpret and relate to others. In some circumstances, however, this may lead to gross mistakes (called egocentricity bias in the emotional domain EEB), to avoid them cerebral mechanisms are activated about which still little is known.

I'm ok, you're not ok

Egoism and narcissism appear to be on the rise in our society, while empathy is on the decline. And yet, the ability to put ourselves in other people's shoes is extremely important for our coexistence. A research team headed by Tania Singer from the Max Planck Institute for Human Cognitive and Brain Sciences has discovered that our own feelings can distort our capacity for empathy. This emotionally driven egocentricity is recognised and corrected by the brain.

Depression in newly diagnosed PD patients linked to reduced striatal dopamine synthesis

Amsterdam, NL, 9 October 2013 – According to the Parkinson's Disease Foundation, up to 60% of individuals with Parkinson's disease (PD) exhibit mild to moderate depression, which is often underdiagnosed. It is unclear whether depression results from having a debilitating disease or reflects a parallel abnormal change in the brain caused by PD pathophysiology.

Single gene mutation linked to diverse neurological disorders

A research team, headed by Theodore Friedmann, MD, professor of pediatrics at the University of California, San Diego School of Medicine, says a gene mutation that causes a rare but devastating neurological disorder known as Lesch-Nyhan syndrome appears to offer clues to the developmental and neuronal defects found in other, diverse neurological disorders like Alzheimer's, Parkinson's and Huntington's diseases.

First-ever study reveals smell of sweat may alter how women are judged

(Cincinnati, OH) - Today, a new study from P&G Beauty, the makers of SecretTM deodorants, and lead investigator Pamela Dalton, PhD. MPH, member of the Monell Chemical Senses Center, confirms for the first time that the smell of stress sweat does, in fact, significantly alter how women are perceived by both males and females. Results of the study, published on October 9, 2013 in PLOS ONE, indicate that the odor from stress-related sweat specifically impacts social judgments of one's confidence, trustworthiness and competence.

New technique allows anti-breast cancer drugs to cross blood-brain barrier

Some breast cancer drugs can penetrate the blood-brain barrier (BBB), but they have not been very effective against brain metastases, whereas other, more effective anti-breast cancer drugs cannot penetrate the BBB at all. In a study published October 9 in the Journal of the National Cancer Institute, researchers used a new approach to selectively permeabilize the BBB at sites of brain metastases, even those 200 times smaller than currently detectable in the clinic.

Why we can't accurately judge our friends' behavior

October 9, 2013 - There is no such thing as objectivity when it comes to your friends: According to a new study, people evaluate their friends' behavior more positively than do strangers, regardless of actual performance on a series of tasks. Researchers say that we should then think twice before allowing people who know each other to be in positions to judge each other – from job interviews to legal settings.

New strategy to treat multiple sclerosis shows promise in mice

LA JOLLA, CA—October 9, 2013—Scientists at The Scripps Research Institute (TSRI) have identified a set of compounds that may be used to treat multiple sclerosis (MS) in a new way. Unlike existing MS therapies that suppress the immune system, the compounds boost a population of progenitor cells that can in turn repair MS-damaged nerve fibers.

One of the newly identified compounds, a Parkinson's disease drug called benztropine, was highly effective in treating a standard model of MS in mice, both alone and in combination with existing MS therapies.

New strategy lets cochlear implant users hear music

For many, music is a universal language that unites people when words cannot. But for those who use cochlear implants -- technology that allows deaf and hard of hearing people to comprehend speech -- hearing music remains extremely challenging.