A low level of response (LR) to alcohol reflects at least in part a low brain response to alcohol and carries significant risk for the later development of alcoholism.
This study used functional magnetic resonance imaging (fMRI) to examine brain activation in individuals with low and high LRs to alcohol while they performed a cognitive task.
Significant differences detected in brain activation may contribute to the inability by individuals with a low LR to recognize modest levels of alcohol intoxication.