Treating brain tumors with whole brain radiation therapy can damage healthy brain tissue, but a new study in mice reveals that limiting the oxygen supply, or hypoxia, can alleviate some of the cognitive impairment caused by the radiation. The results are reported in the Jan. 18 issue of the online journal PLoS ONE.
The researchers, led by William Sonntag of University of Oklahoma, exposed the mice to a clinically relevant regimen of radiation, which caused progressive deterioration of spatial learning starting about two months post-radiation.